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J Clin Med. 2020 May 06;9(5). doi: 10.3390/jcm9051366.

Adenosine and the Cardiovascular System: The Good and the Bad.

Journal of clinical medicine

Régis Guieu, Jean-Claude Deharo, Baptiste Maille, Lia Crotti, Ermino Torresani, Michele Brignole, Gianfranco Parati

Affiliations

  1. C2VN INSERM, INRAE, Aix Marseille University, 13005 Marseille, France.
  2. Laboratory of Biochemistry, Timone Hospital, 13005 Marseille, France.
  3. Department of Cardiology, Hôpital La Timone Adultes, 13005 Marseille, France.
  4. Department of Medicine and Surgery, University of Milano Bicocca, 20122 Milan, Italy.
  5. IRCCS, Department of Cardiovascular, Istituto Auxologico Italiano, Neural and Metabolic Sciences, San Luca Hospital, 20122 Milan, Italy.
  6. IRCCS, Istituto Auxologico Italiano, Cardiomyopathy Center and Center for Cardiac Arrhythmias of Genetic Origin, 20122 Milan, Italy.
  7. IRCCS, Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano, 20122 Milan, Italy.
  8. IRCCS Istituto Auxologico Italiano, Faint & Fall Programme, Ospedale San Luca, 20122 Milano, Italy.
  9. Department of Cardiology, Arrhythmology Centre and Syncope Unit, Ospedali del Tigullio 16033, Lavagna, Italy.

PMID: 32384746 PMCID: PMC7290927 DOI: 10.3390/jcm9051366

Abstract

Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its membrane receptors, named A

Keywords: adenosine receptors; cardiovascular diseases

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. J Neurochem. 2005 May;93(3):595-604 - PubMed
  2. Sleep. 2018 Mar 1;41(3): - PubMed
  3. Cardiovasc Res. 1996 Nov;32(5):797-813 - PubMed
  4. Am J Physiol. 1963 Feb;204:317-22 - PubMed
  5. FASEB J. 2003 Feb;17(2):280-2 - PubMed
  6. J Physiol. 1998 Jun 1;509 ( Pt 2):507-18 - PubMed
  7. FASEB J. 1995 Mar;9(5):359-65 - PubMed
  8. Gen Pharmacol. 1998 Mar;30(3):351-6 - PubMed
  9. Eur Heart J. 1988 Dec;9 Suppl N:34-9 - PubMed
  10. Antioxid Redox Signal. 2009 Nov;11(11):2641-50 - PubMed
  11. J Cereb Blood Flow Metab. 2010 Apr;30(4):808-15 - PubMed
  12. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1655-60 - PubMed
  13. Sci Rep. 2018 Dec 13;8(1):17829 - PubMed
  14. Ann Saudi Med. 2014 Jul-Aug;34(4):308-13 - PubMed
  15. Circ Res. 2014 Mar 14;114(6):1004-21 - PubMed
  16. Eur J Pharmacol. 2019 Jan 5;842:111-117 - PubMed
  17. J Physiol. 1988 Nov;405:615-33 - PubMed
  18. Cardiovasc Res. 2006 Nov 1;72(2):292-302 - PubMed
  19. Hypertens Res. 2007 Sep;30(9):781-7 - PubMed
  20. Circ J. 2020 Feb 25;84(3):404-410 - PubMed
  21. Cardiovasc Res. 1993 Jan;27(1):18-27 - PubMed
  22. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6541-6 - PubMed
  23. J Am Coll Cardiol. 2015 Jul 14;66(2):204-5 - PubMed
  24. Nature. 2014 May 15;509(7500):310-7 - PubMed
  25. Biochem Biophys Res Commun. 2005 Dec 2;337(4):1145-52 - PubMed
  26. Purinergic Signal. 2019 Mar;15(1):45-52 - PubMed
  27. Curr Neuropharmacol. 2009 Sep;7(3):238-45 - PubMed
  28. Am J Emerg Med. 2012 Nov;30(9):2082.e3-5 - PubMed
  29. Rev Esp Cardiol (Engl Ed). 2016 Dec;69(12):1167 - PubMed
  30. Rev Esp Cardiol. 2006 Jun;59(6):559-66 - PubMed
  31. Int J Cardiol. 2016 Jan 1;202:228-37 - PubMed
  32. Hypertension. 2018 Aug;72(2):511-521 - PubMed
  33. Pacing Clin Electrophysiol. 1994 Nov;17(11 Pt 1):1814-7 - PubMed
  34. Eur Respir Rev. 2009 Mar;18(111):13-7 - PubMed
  35. Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1166-75 - PubMed
  36. Circulation. 2008 Oct 21;118(17):1691-3 - PubMed
  37. Biochim Biophys Acta. 2000 Mar 17;1500(3):280-90 - PubMed
  38. Am J Respir Crit Care Med. 2012 Oct 15;186(8):780-9 - PubMed
  39. J Electrocardiol. 2016 Mar-Apr;49(2):171-3 - PubMed
  40. Front Pharmacol. 2017 Dec 04;8:858 - PubMed
  41. Pharmacol Ther. 2013 Oct;140(1):92-111 - PubMed
  42. Circulation. 2002 Jul 30;106(5):569-74 - PubMed
  43. Int J Cardiol. 2014 Jul 1;174(3):741-3 - PubMed
  44. Am J Physiol. 1990 Jun;258(6 Pt 2):H1815-22 - PubMed
  45. Cardiovasc Res. 2003 Dec 1;60(3):529-37 - PubMed
  46. J Appl Physiol (1985). 2017 Oct 1;123(4):951-956 - PubMed
  47. J Pharmacol Exp Ther. 1998 Aug;286(2):1051-7 - PubMed
  48. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12441-5 - PubMed
  49. Handb Exp Pharmacol. 2009;(193):161-88 - PubMed
  50. Heart. 2012 Jun;98(11):855-9 - PubMed
  51. Nature. 1997 Aug 14;388(6643):674-8 - PubMed
  52. J Pharmacol Exp Ther. 2000 Feb;292(2):752-60 - PubMed
  53. Circulation. 1997 Dec 2;96(11):3921-7 - PubMed
  54. Am J Emerg Med. 2000 Mar;18(2):234-5 - PubMed
  55. Prog Clin Biol Res. 1987;230:109-18 - PubMed
  56. Microvasc Res. 1997 Nov;54(3):243-52 - PubMed
  57. Pacing Clin Electrophysiol. 2001 Apr;24(4 Pt 1):450-5 - PubMed
  58. Am J Physiol. 1999 Mar;276(3):R790-8 - PubMed
  59. Circ Res. 1992 Apr;70(4):743-53 - PubMed
  60. Drugs. 2007;67 Suppl 2:15-24 - PubMed
  61. Circulation. 1991 Sep;84(3):1145-9 - PubMed
  62. Blood. 2014 Aug 14;124(7):1029-37 - PubMed
  63. Circ Res. 2017 Jan 6;120(1):207-228 - PubMed
  64. Blood. 2006 Sep 1;108(5):1602-10 - PubMed
  65. Circ Res. 2015 Mar 27;116(7):1254-68 - PubMed
  66. Can J Physiol Pharmacol. 1996 Jan;74(1):15-22 - PubMed
  67. Am J Med. 1992 Jun;92(6):655-64 - PubMed
  68. Eur Heart J. 2011 Mar;32(6):721-9 - PubMed
  69. Circ Arrhythm Electrophysiol. 2013 Jun;6(3):e34-7 - PubMed
  70. J Physiol. 2014 Jun 15;592(12):2575-90 - PubMed
  71. Eur J Pharmacol. 1993 Jul 15;246(2):105-11 - PubMed
  72. Circ Res. 2006 Nov 10;99(10):1117-24 - PubMed
  73. Cardiol Clin. 2015 Aug;33(3):441-7 - PubMed
  74. Int J Mol Sci. 2015 Jan 26;16(2):2732-46 - PubMed
  75. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H719-25 - PubMed
  76. J Cardiovasc Pharmacol. 1993 May;21(5):822-8 - PubMed
  77. J Am Coll Cardiol. 2004 Jun 16;43(12 Suppl S):13S-24S - PubMed
  78. Nat Commun. 2017 Feb 07;8:14108 - PubMed
  79. Circ J. 2018 Dec 25;83(1):156-163 - PubMed
  80. JAMA. 1982 Sep 10;248(10):1185-9 - PubMed
  81. Am J Physiol. 1999 Dec;277(6):F926-33 - PubMed
  82. Am J Cardiol. 2000 Apr 1;85(7):858-63 - PubMed
  83. Cardiovasc Res. 2002 Feb 1;53(2):326-33 - PubMed
  84. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1118-26 - PubMed
  85. Eur Heart J. 2006 Feb;27(4):469-75 - PubMed
  86. Chest. 2002 Nov;122(5):1686-94 - PubMed
  87. J Vasc Res. 2011;48(2):171-83 - PubMed
  88. Am Heart J. 1992 Mar;123(3):794-6 - PubMed
  89. Circulation. 1998 Aug 18;98(7):711-8 - PubMed
  90. Am J Med. 1982 Jul;73(1):15-23 - PubMed
  91. Circulation. 1997 Mar 18;95(6):1363-5 - PubMed
  92. Heart. 2009 Apr;95(8):651-5 - PubMed
  93. Exp Neurol. 1999 Oct;159(2):545-50 - PubMed
  94. Curr Opin Pulm Med. 2000 Nov;6(6):485-9 - PubMed
  95. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):870-8 - PubMed
  96. Antioxid Redox Signal. 2011 Oct 15;15(8):2221-34 - PubMed
  97. Acta Physiol (Oxf). 2010 Jun;199(2):211-20 - PubMed
  98. Prog Cardiovasc Dis. 1999 May-Jun;41(6):481-98 - PubMed
  99. Cells. 2020 Mar 24;9(3): - PubMed
  100. Basic Res Cardiol. 1997 Aug;92(4):240-51 - PubMed
  101. Heart Rhythm. 2016 May;13(5):1151-1154 - PubMed
  102. Heart Rhythm. 2014 Jan;11(1):101-9 - PubMed
  103. Adv Exp Med Biol. 2018;1071:89-93 - PubMed
  104. J Cardiovasc Pharmacol. 2013 Jan;61(1):70-6 - PubMed
  105. Kidney Int. 2006 Aug;70(4):690-8 - PubMed
  106. Circulation. 2016 Aug 2;134(5):405-21 - PubMed
  107. Ann Saudi Med. 2012 Jan-Feb;32(1):37-42 - PubMed
  108. Am J Physiol. 1993 Nov;265(5 Pt 2):H1471-7 - PubMed
  109. Int J Mol Sci. 2019 Nov 03;20(21): - PubMed
  110. Blood. 2008 Jun 15;111(12):5571-80 - PubMed
  111. Cardiovasc Res. 2001 Oct;52(1):25-39 - PubMed
  112. Circulation. 1999 Nov 2;100(18):1879-86 - PubMed
  113. Am J Cardiol. 1997 Jun 19;79(12A):2-10 - PubMed
  114. Hypertension. 2020 Jan;75(1):109-118 - PubMed
  115. Coron Artery Dis. 2000 Dec;11(8):607-13 - PubMed
  116. Circ Res. 1995 Jul;77(1):194-8 - PubMed
  117. Emerg Med J. 2004 Jul;21(4):408-10 - PubMed
  118. Int J Cardiol. 2019 Aug 15;289:70-73 - PubMed
  119. Eur Heart J. 2004 Dec;25(24):2243-78 - PubMed
  120. Rev Esp Cardiol (Engl Ed). 2016 Feb;69(2):177 - PubMed
  121. Basic Res Cardiol. 2009 Sep;104(5):469-83 - PubMed
  122. Am J Physiol. 1998 Nov;275(5):H1663-72 - PubMed
  123. Circ Res. 2013 May 24;112(11):1466-78 - PubMed
  124. Circ Res. 1983 Sep;53(3):287-97 - PubMed
  125. Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2789-95 - PubMed
  126. Heart Vessels. 1995;10(3):119-27 - PubMed
  127. Thromb Haemost. 2020 Feb;120(2):253-261 - PubMed
  128. Am J Emerg Med. 1993 Mar;11(2):192-4 - PubMed
  129. Nat Rev Drug Discov. 2013 Apr;12(4):265-86 - PubMed
  130. Basic Res Cardiol. 2008 May;103(3):203-15 - PubMed
  131. Cardiovasc Res. 1998 Oct;40(1):74-87 - PubMed
  132. J Cardiovasc Electrophysiol. 2004 May;15(5):615; author reply 615-6 - PubMed
  133. Eur Heart J. 2009 Jun;30(12):1510-5 - PubMed
  134. Crit Care Med. 2018 Sep;46(9):e874-e880 - PubMed
  135. Hypertension. 2004 Nov;44(5):649-54 - PubMed
  136. Circ Res. 2005 Jul 8;97(1):1-3 - PubMed
  137. Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1472-81 - PubMed
  138. Am Heart J. 1995 Sep;130(3 Pt 1):564-71 - PubMed
  139. Circulation. 1992 Sep;86(3):986-94 - PubMed
  140. Cardiology. 2012;122(1):23-35 - PubMed
  141. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H437-44 - PubMed
  142. Ann Intern Med. 1997 Sep 15;127(6):417-22 - PubMed
  143. Prehosp Emerg Care. 2000 Apr-Jun;4(2):196-8 - PubMed
  144. Biochem Biophys Res Commun. 2014 Jul 18;450(1):93-8 - PubMed
  145. Am J Ther. 2002 Mar-Apr;9(2):141-7 - PubMed
  146. Circulation. 2016 Dec 6;134(23):e648-e649 - PubMed
  147. Front Pharmacol. 2018 Jun 14;9:627 - PubMed
  148. BMC Pharmacol Toxicol. 2016 May 23;17(1):23 - PubMed
  149. Hypertension. 1999 Jan;33(1 Pt 2):511-6 - PubMed
  150. Medicine (Baltimore). 2016 Feb;95(8):e2876 - PubMed
  151. Physiol Rev. 2018 Jul 1;98(3):1591-1625 - PubMed
  152. J Mol Cell Cardiol. 1998 Jan;30(1):187-93 - PubMed
  153. Chest. 1993 Apr;103(4):1299-301 - PubMed
  154. Int J Mol Sci. 2019 Nov 27;20(23): - PubMed
  155. J Cell Physiol. 1985 Nov;125(2):330-6 - PubMed
  156. J Exp Med. 1997 Nov 3;186(9):1615-20 - PubMed
  157. N Engl J Med. 1998 Sep 3;339(10):659-66 - PubMed
  158. J Exp Med. 2005 Dec 5;202(11):1493-505 - PubMed
  159. Pharmacol Rev. 2011 Mar;63(1):1-34 - PubMed
  160. Am J Physiol. 1986 Feb;250(2 Pt 2):H173-80 - PubMed
  161. Handb Exp Pharmacol. 2009;(193):383-97 - PubMed
  162. Molecules. 2019 Nov 19;24(22): - PubMed
  163. Circulation. 2008 Oct 21;118(17):1713-21 - PubMed
  164. Eur J Pharmacol. 1996 Aug 1;309(1):111-4 - PubMed
  165. Eur J Clin Invest. 2000 Feb;30(2):105-10 - PubMed
  166. Heart Rhythm. 2017 Feb;14(2):234-239 - PubMed
  167. Microcirculation. 2010 Nov;17(8):600-7 - PubMed
  168. BMJ Open. 2019 May 29;9(5):e028007 - PubMed
  169. J Am Coll Cardiol. 2000 Jan;35(1):83-8 - PubMed
  170. Int J Cardiol. 2013 Oct 12;168(5):e138-41 - PubMed
  171. Biochem Biophys Res Commun. 1994 Mar 15;199(2):905-10 - PubMed
  172. Front Neurosci. 2019 Jan 23;12:1058 - PubMed
  173. Int J Clin Pract. 2018 Mar;72(3):e13070 - PubMed
  174. Handb Exp Pharmacol. 2009;(193):189-214 - PubMed
  175. Cardiovasc Res. 1997 May;34(2):337-47 - PubMed
  176. Circulation. 2006 Sep 26;114(13):1410-6 - PubMed
  177. Cell Signal. 2014 May;26(5):1060-7 - PubMed
  178. Hypertension. 2002 Dec;40(6):909-13 - PubMed
  179. Hypertens Res. 2020 May;43(5):466-469 - PubMed
  180. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):792-6 - PubMed
  181. Cardiovasc Res. 1999 Jul;43(1):228-36 - PubMed
  182. J Am Coll Cardiol. 2016 Apr 26;67(16):1967-8 - PubMed
  183. Herzschrittmacherther Elektrophysiol. 2018 Jun;29(2):166-170 - PubMed
  184. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2322-33 - PubMed
  185. J Cardiovasc Electrophysiol. 1996 Dec;7(12):1132-44 - PubMed
  186. Circulation. 1995 Oct 1;92(7):1954-68 - PubMed

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