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Goth CK, Petäjä-Repo UE, Rosenkilde MM. G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications. ACS Pharmacol Transl Sci. 2020;3(2):237-245doi: 10.1021/acsptsci.0c00016.
Goth, C. K., Petäjä-Repo, U. E., & Rosenkilde, M. M. (2020). G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications. ACS pharmacology & translational science, 3(2), 237-245. https://doi.org/10.1021/acsptsci.0c00016
Goth, Christoffer K, et al. "G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications." ACS pharmacology & translational science vol. 3,2 (2020): 237-245. doi: https://doi.org/10.1021/acsptsci.0c00016
Goth CK, Petäjä-Repo UE, Rosenkilde MM. G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications. ACS Pharmacol Transl Sci. 2020 Mar 17;3(2):237-245. doi: 10.1021/acsptsci.0c00016. eCollection 2020 Apr 10. PMID: 32296765; PMCID: PMC7155200.
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ACS Pharmacol Transl Sci. 2020 Mar 17;3(2):237-245. doi: 10.1021/acsptsci.0c00016. eCollection 2020 Apr 10.

G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications.

ACS pharmacology & translational science

Christoffer K Goth, Ulla E Petäjä-Repo, Mette M Rosenkilde

Affiliations

  1. Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK 2200, Denmark.
  2. Medical Research Center Oulu, Research Unit of Biomedicine, University of Oulu, Oulu, FI-90014, Finland.

PMID: 32296765 PMCID: PMC7155200 DOI: 10.1021/acsptsci.0c00016

Abstract

Post-translational modifications (PTMs) are a fundamental phenomenon across all classes of life and several hundred different types have been identified. PTMs contribute widely to the biological functions of proteins and greatly increase their diversity. One important class of proteins regulated by PTMs, is the cell surface expressed G protein-coupled receptors (GPCRs). While most PTMs have been shown to exert distinct biological functions, we are only beginning to approach the complexity that the potential interplay between different PTMs may have on biological functions and their regulation. Importantly, PTMs and their potential interplay represent an appealing mechanism for cell and tissue specific regulation of GPCR function and may partially contribute to functional selectivity of some GPCRs. In this review we highlight examples of PTMs located in GPCR extracellular domains, with special focus on glycosylation and the potential interplay with other close-by PTMs such as tyrosine sulfation, proteolytic cleavage, and phosphorylation.

Copyright © 2020 American Chemical Society.

Conflict of interest statement

The authors declare no competing financial interest.

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