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Jokinen E. Coronary artery disease in patients with congenital heart defects. J Intern Med. 2020;288(4):383-389doi: 10.1111/joim.13080.
Jokinen, E. (2020). Coronary artery disease in patients with congenital heart defects. Journal of internal medicine, 288(4), 383-389. https://doi.org/10.1111/joim.13080
Jokinen, E. "Coronary artery disease in patients with congenital heart defects." Journal of internal medicine vol. 288,4 (2020): 383-389. doi: https://doi.org/10.1111/joim.13080
Jokinen E. Coronary artery disease in patients with congenital heart defects. J Intern Med. 2020 Oct;288(4):383-389. doi: 10.1111/joim.13080. Epub 2020 May 11. PMID: 32391638.
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J Intern Med. 2020 Oct;288(4):383-389. doi: 10.1111/joim.13080. Epub 2020 May 11.

Coronary artery disease in patients with congenital heart defects.

Journal of internal medicine

E Jokinen

Affiliations

  1. Pediatric Cardiology, Pediatric Research Center, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

PMID: 32391638 DOI: 10.1111/joim.13080

Abstract

The prognosis of patients with congenital heart defects has improved significantly: more and more patients reach adulthood and old age. At the same time, the possibility of cardiovascular morbidity increases. The conventional risk factors for coronary artery disease are at least as high or even higher in patients than in the general population. Obesity and sedentary life style are more common in adults with congenital heart defect (ACHD) than in general population. In some patients, for example those with coarctation of the aorta or patients with operated coronary arteries in the infancy, the incidence of coronary artery disease (CAD) is clearly increased. In some patients with cyanotic heart defects (e.g. Fontan), the incidence of CAD might be lower, but it usually returns to the average level or higher after correction of the defect. Coronary artery disease is one of the most important reasons for mortality also in ACHD patients, and the consequences of a coronary event might be more fateful in a patient with a corrected congenital heart defect than in her/his peer. There should be a paradigm shift from operative mortality and short-term outcome to long-term morbidity and prevention of cardiovascular disease - a task that often has been forgotten during follow-up visits.

© 2020 The Association for the Publication of the Journal of Internal Medicine.

Keywords: cardiology; congenital heart defects; coronary artery disease

References

  1. Alireza R, Heta N, Jari H, Heikki S, Eero J. Late causes of death after pediatric cardiac surgery. A 60-year population-based study. Am Coll Cardiol 2016; 68: 487-98. - PubMed
  2. Tutarel O, Kempny A, Alonso-Gonzalez R et al. Congenital heart disease beyond the age of 60: emergence of a new population with high resource utilization, high morbidity, and high mortality. Eur Heart J 2014; 35: 725-32. - PubMed
  3. WHO Global Heart initiative. 2019. www.who.int/globalhearts. - PubMed
  4. The Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC) Endorsed by the Association for European Paediatric Cardiology (AEPC). Guidelines for the management of grown-up congenital heart disease(new version 2010). Eur Heart J 2010; 31: 2915-57. - PubMed
  5. Stout Karen K, Daniels Curt J, Aboulhosn Jamil A et al. 2018 AHA/ACC guideline for the management of adults with congenital heart disease. A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2019;139:e698-e800. - PubMed
  6. Lin Y-S, Liu P-H, Wu L-S et al. Major adverse cardiovascular events in adult congenital heart disease: a population-based follow-up study from Taiwan. BMC Cardiovasc Disord 2014; 14: 38. - PubMed
  7. Giannakoulas G, Dimopoulos K, Engel Goktekin O et al. Burden of coronary artery disease in adults with congenital heart disease and its relation to congenital and traditional heart risk factors. The American Journal of Cardiology 2009; 103: 1445-50. - PubMed
  8. Gikas A, Lambadiari V, Sotiropoulos A, Panagiotakos A, Pappas S. Prevalence of major cardiovascular risk factors and coronary heart disease in a sample of greek adults: The Saronikos Study. Open Cardiovasc Med J 2016; 10: 69-80. - PubMed
  9. Benjamin EJ, Virani SS, Callaway CW et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation 2018; 137: e67-e492. - PubMed
  10. Kondo C, Nakazawa M, Mmma K, Kusakabe K. Sympathetic denervation and reinnervation after arterial switch operation for complete transposition. Circulation 1998; 97: 2414-9. - PubMed
  11. Olsen M, Marino B, Kaltman J et al. Myocardial infarction in adults with congenital heart disease. Am J Cardiol. 2017; 120: 2272-7. - PubMed
  12. Yalonetsky S, Horlick E, Osten M, Benson L, Oechslin E, Silversides C. Clinical characteristics of coronary artery disease in adults with congenital heart defects. Int J Cardiol 2013; 164: 217-20. - PubMed
  13. Moons P, Van Deyk K, Dedroog D, Troost E, Budts W. Prevalence of cardiovascular risk factors in adults with congenital heart disease. Eur J Cardiovasc Prev Rehabil 2006; 13: 612-6. - PubMed
  14. Afilalo J, Therrien J, Pilote L et al. Geriatric congenital heart disease - burden of disease and predictors of mortality. Am Coll Cardiol 2011; 58: 1509-15. - PubMed
  15. Clarkson PM, Nicholas MR, Barratt-Boyes BG, Neutze JM, Whitlock RM. Results after repair of coarctation of the aorta beyond infancy: a 10 to 28 year follow-up with particular reference to late systemic hypertension. Am J Cardiol 1983; 51: 1481-8. - PubMed
  16. De Groote K, Demulier L, De Backer J et al. Arterial hypertension in Turner syndrome: a review of the literature and a practical approach for diagnosis and treatment. J Hypertens 2015; 33: 1342-51. - PubMed
  17. Bokma J, Zegstroo I, Kuijpers JM et al. Factors associated with coronary artery disease and´stroke in adults with congenital heart disease. Heart 2018; 104: 574-80. - PubMed
  18. Zomer AC, Vaartjes I, Uiterwaal CS et al. Social burden and lifestyle in adults with congenital heart disease. Am J Cardiol 2012; 109: 1657-63. - PubMed
  19. Lui GK, Rogers IS, Ding VY et al. Risk estimates for atherosclerotic cardiovascular disease in adults with congenital heart disease. Am J Cardiol 2017; 119: 112-8. - PubMed
  20. Martinez SC, Byku M, Novak EL et al. Increased body mass index is associated with congestive heart failure and mortality in adult Fontan patients. Congenit Heart Dis 2016; 11: 71e79. - PubMed
  21. Buelow MW, Earing MG, Hill GD et al. The impact of obesity on postoperative outcomes in adults with congenital heart disease undergoing pulmonary valve replacement. Congenit Heart Dis 2015; 10: 197e202. - PubMed
  22. Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA 2004; 291: 2847-50. - PubMed
  23. Shustak RJ, McGuire SB, October TW, Phoon CK, Chun AJ. Prevalence of obesity among patients with congenital and acquired heart disease. Pediatr Cardiol 2012; 33: 8-14. - PubMed
  24. Lerman Joseph B, Parness Ira A, Shenoy Rajesh U. Body weights in adults with congenital heart disease and the obesity frequency. Am J Cardiol 2017; 119: 638e642. - PubMed
  25. Kempny A, Dimopoulos K, Uebing A, Moceri P, Swan L, Gatzoulis MA. Diller GP. Reference values for exercise limitations among adults with congenital heart disease. Relation to activities of daily life-single centre experience and review of published data. EurHeart J 2012; 33: 1386e1396. - PubMed
  26. Pinto N, Marino B, Wernovsky G et al. Obesity is a common comorbidity in children with congenital and acquired heart disease. Pediatrics 2007; 120: e1157-64. - PubMed
  27. Chen C-A, Jou-Kou Wang J-K, Lue H-C, Hua Y-C, Chang M-H, Wu M-H. A shift from underweight to overweight and obesity in asian children and adolescents with congenital heart disease. Paediatr Perinat Epidemiol 2012; 26: 336-43. - PubMed
  28. Deen JF, Krieger EV, Slee AE et al. Metabolic SYNDROME in adults with congenital heart disease. J Am Heart Assoc 2016; 2: 5. - PubMed
  29. Fuenmayor G, Costa Redondo A, Shiraishi K, Souza R, Elias P, Jatene I. Prevalence of dyslipidemia in children with congenital heart disease. Arq Bras Cardiol. 2013; 101: 273-6. - PubMed
  30. Ghaderian M, Emami-Moghadam A, Samir M, Zadeh M, Saadim A. Lipid and glucose serum levels in children with congenital heart disease. J Teh Univ Heart Ctr 2014; 9: 20-6. - PubMed
  31. Martínez-Quintanaa E, Rodríguez-Gonzálezb F, Nieto-Lagoa V, Nóvoac F, López-Riosd L, Riaño-Ruize M. Serum glucose and lipid levels in adult congenital heart disease patients. Metab, Clin Exp 2010; 59: 1642-8. - PubMed
  32. Kovacs A, Sears S, Saidi A. Biopsychosocial experiences of adults with congenital heart disease: Review of the literature. Am Heart J 2005; 150: 193-201. - PubMed
  33. Kempny A, Dimopoulos K, Uebing A et al. Reference values for exercise limitations among adults with congenital heart disease. Relation to activities of daily life-single centre experience and review of published data. Eur Heart J 2012; 33: 1386-96. - PubMed
  34. Ray T, Green A, Henry K. Physical activity and obesity in children with congenital cardiac disease. Cardiol Young 2011; 21: 603-7. - PubMed
  35. Uzark K, Jones K, Slusher J, Limbers C, Burwinkle T, Varni J. Quality of life in children with heart disease as perceived by children and parents. Pediatrics 2008; 121: e1060-7. - PubMed
  36. Roifman I, Therrien J, Ionescu-Ittu R et al. Coarctation of the aorta and coronary artery disease: fact or fiction? Circulation 2012; 126: 16-21. - PubMed
  37. Toro-Salazar OH, Steinberger J, Thomas W, Rocchini AP, Carpenter B, Moller JH. Long-term follow-up of patients after coarctation of the aorta repair. Am J Cardiol. 2002; 89: 541-7. - PubMed
  38. Di Salvo G, Castaldi B, Baldini L et al. Masked hypertension in young patients after successful aortic coarctation repair: impact on left ventricular geometry and function. J Hum Hypertens 2011; 25: 739-45. - PubMed
  39. Brili S, Tousoulis D, Antoniades C et al. Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta. Atherosclerosis 2005; 182: 97-103. - PubMed
  40. Viuff M, Trolle C, Wen J et al. Coronary artery anomalies in Turner Syndrome. J Cardiovas Computed Tomography 2016; 10: 480-4. - PubMed
  41. Tsuda T, Bhat A, Robinson B, Baffa J, Radtke Wolfgang: Coronary artery problems late after arterial switch operation for transposition of the great arteries. Circ J 2015; 79: 2372-9. - PubMed
  42. Angeli E, Formigari R, Napoleone C et al. Long-term coronary artery outcome after arterial switch operation for transposition of the great arteries. Eur J Cardiothorac Surg 2010; 38: 714-20. - PubMed
  43. Lim H-G, Kim W-H, Lee J, Kim J. Long-term results of the arterial switch operation for ventriculo-arterial discordance. Eur J Cardiothorac Surg 2013; 43: 325-34. - PubMed
  44. Possner M, Buechel R, Vontobel J et al. Myocardial blood flow and cardiac sympathetic innervation in young adults late after arterial switch operation for transposition of the great arteries. Int J Cardiol 2020; 299: 110-5. - PubMed
  45. Perloff JK. The coronary circulation in cyanotic congenital heart disease. Int J Cardiol 2004; 97: 79-86. - PubMed
  46. Duffels M, Mulder K, Trip M et al. Atherosclerosis in patients with cyanotic congenital heart disease. Circulation 2010; 74: 1436-41. - PubMed
  47. Fyfe A, Perloff J, Niwa K, Child J, Miner P. Cyanotic Congenital Heart Disease and Coronary Artery Atherogenesis. Am J Cardiol 2005; 96: 283-90. - PubMed
  48. Brida M, Dimopoulos K, Kempny A et al. Body mass index in adult congenital heart disease. Heart 2017; 103: 1250-7. - PubMed
  49. Abraham D, Freeman L, Lewis C, O'Sullivan M. Coronary artery disease in Eisenmenger's syndrome - Rare but not to be forgotten. Int J Cardiol 2016; 203: 276-7. - PubMed
  50. Tarp J, Sørgaard M, Christoffersen C et al. Subclinical atherosclerosis in patients with cyanotic congenital heart disease. Int J Cardiol 2019; 277: 97-103. - PubMed
  51. Bradley E, Parker J, Novak E, Ludbrook P, Billadello J, Cedars A. Cardiovascular disease in late survivors of tetralogy of fallot. A tertiary care center experience. Tex Heart Inst J 2013; 40: 418-23. - PubMed
  52. Egbe A, Ananthaneni S, Jaday R et al. Coronary artery disease in adults with tetralogy of Fallot. Congenit Heart Dis 2019; 14: 491-7. - PubMed
  53. Rovio SP, Pahkala K, Nevalainen J et al. Cardiovascular risk factors from childhood and midlife cognitive performance. J Am College Cardiol 2017; 69: 2279-89. - PubMed
  54. Laitinen TT, Nuotio J, Juonala M et al. Success in achieving the targets of the 20-year infancy-onset dietary intervention: association with insulin sensitivity and serum lipid. Diabetes Care 2018; 41: 2236-44. - PubMed
  55. Juhola J, Magnussen CG, Viikari JSA et al. Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study. J Pediatr 2011; 159: 584-90. - PubMed
  56. Evensen E, Wilsgaard T, Furberg A-S, Skeie G. Tracking of overweight and obesity from early childhood to adolescence in a population-based cohort - the Tromsø Study, Fit Futures. BMC Pediatr 2016; 16: 64. - PubMed
  57. Longmuir P, Brothers J, de Ferranti S et al. Promotion of physical activity for children and adults with congenital heart disease A scientific statement from the american heart association. Circulation 2013; 127: 2147-59. - PubMed
  58. Häcker A-L, Oberhoffer R, Hager A, Ewert P, Müller J. Age-related cardiovascular risk in adult patients with congenital heart disease. Int J Cardiol 2019; 27: 90-6. - PubMed

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