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Rashid MH, Yasir HKM, Piracha MU, et al. Review Analysis on Thymectomy vs Conservative Medical Management in Myasthenia Gravis. Cureus. 2020;12(3):e7425doi: 10.7759/cureus.7425.
Rashid, M. H., Yasir, H. K. M., Piracha, M. U., Salman, U., & Yousaf, H. (2020). Review Analysis on Thymectomy vs Conservative Medical Management in Myasthenia Gravis. Cureus, 12(3), e7425. https://doi.org/10.7759/cureus.7425
Rashid, Muhammad Humayoun, et al. "Review Analysis on Thymectomy vs Conservative Medical Management in Myasthenia Gravis." Cureus vol. 12,3 (2020): e7425. doi: https://doi.org/10.7759/cureus.7425
Rashid MH, Yasir HKM, Piracha MU, Salman U, Yousaf H. Review Analysis on Thymectomy vs Conservative Medical Management in Myasthenia Gravis. Cureus. 2020 Mar 26;12(3):e7425. doi: 10.7759/cureus.7425. PMID: 32337145; PMCID: PMC7182154.
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Cureus. 2020 Mar 26;12(3):e7425. doi: 10.7759/cureus.7425.

Review Analysis on Thymectomy vs Conservative Medical Management in Myasthenia Gravis.

Cureus

Muhammad Humayoun Rashid, Hafiz Khawaja Muhammad Yasir, Muhammad Usman Piracha, Umer Salman, Hamza Yousaf

Affiliations

  1. Neurology, Bakhtawar Amin Medical and Dental College, Multan, PAK.
  2. Internal Medicine, Nishtar Medical University and Hospital, Multan, PAK.
  3. Biochemistry, Bakhtawar Amin Medical and Dental College, Multan, PAK.
  4. Internal Medicine, City Hospital, Multan, PAK.

PMID: 32337145 PMCID: PMC7182154 DOI: 10.7759/cureus.7425

Abstract

Myasthenia gravis (MG) is an acquired, rare autoimmune disease that occurs due to autoantibodies blocking neuromuscular transmission. Its pathophysiology involves production of antibodies against the nicotinic acetylcholine receptors. Patients with negative anti-acetylcholine receptors (AChR) antibodies results are recognized as seronegative myasthenia gravis. In this review we tried to compare surgical and medical management of MG with each other to find out which is more effective. Different clinical trials and retrospective cohorts comparing these two parameters statistically were searched and studied. Remission rates in both medical and surgical management were compared. We found out that rates of remission were better in post thymectomy patients than patients on various medical treatment options including corticosteroids, immunosuppressants, intravenous immunoglobulins and acetylcholinesterase inhibitors alone. Hence thymectomy is studied to be the superior treatment option than other conservative medical management options alone.

Copyright © 2020, Rashid et al.

Keywords: acetylcholinesterase inhibitors; ivig; myasthenia gravis; plasmapheresis; review; thymectomy; treatment options

Conflict of interest statement

The authors have declared that no competing interests exist.

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