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Ponnulakshmi R, Vishnupriya V, Mohan SK, et al. Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer. Bioinformation. 2020;16(3):283-287doi: 10.6026/97320630016283.
Ponnulakshmi, R., Vishnupriya, V., Mohan, S. K., Abilasha, S., Ramajayam, G., Vijayalakshmi, P., Rajalakshmi, M., & Selvaraj, J. (2020). Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer. Bioinformation, 16(3), 283-287. https://doi.org/10.6026/97320630016283
Ponnulakshmi, Rajagopal, et al. "Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer." Bioinformation vol. 16,3 (2020): 283-287. doi: https://doi.org/10.6026/97320630016283
Ponnulakshmi R, Vishnupriya V, Mohan SK, Abilasha S, Ramajayam G, Vijayalakshmi P, Rajalakshmi M, Selvaraj J. Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer. Bioinformation. 2020 Mar 31;16(3):283-287. doi: 10.6026/97320630016283. eCollection 2020. PMID: 32308271; PMCID: PMC7147492.
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Bioinformation. 2020 Mar 31;16(3):283-287. doi: 10.6026/97320630016283. eCollection 2020.

Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer.

Bioinformation

Rajagopal Ponnulakshmi, Veeraraghavan Vishnupriya, Surapaneni Krishna Mohan, Srinivasan Abilasha, Govindan Ramajayam, Periyasamy Vijayalakshmi, Manikkam Rajalakshmi, Jayaraman Selvaraj

Affiliations

  1. Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India.
  2. Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
  3. Department of Biochemistry, Panimalar Medical College Hospital and Research Institute, Varadharajapuram, Poonamallee, Chennai-600 123, Chennai, Tamil Nadu, India.
  4. Department of Anatomy, Asan Memorial Dental College and Hospital, Asan Nagar, Chengalpattu, Tamil Nadu, India.
  5. Multi Disciplinary Research Unit, Madurai Medical College, TamilNadu, India.
  6. DBT-BIF Centre, PG and Research Department of Biotechnology & Bioinformatics, Holy Cross College (autonomous), Trichy, Tamil Nadu, India.

PMID: 32308271 PMCID: PMC7147492 DOI: 10.6026/97320630016283

Abstract

It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleurine, demecolcine, fagaronine and thalicarpine) with beta-catenin for further consideration towards the design and development of potential inhintors for the treatmnet of colon cancer.

© 2020 Biomedical Informatics.

Keywords: ADME; Colon cancer; Molecular docking; β-catenin

References

  1. Drug Discov Today Technol. 2004 Dec;1(4):337-41 - PubMed
  2. Proteins. 2003 Jul 1;52(1):107-12 - PubMed
  3. World J Gastroenterol. 2016 Jan 14;22(2):823-32 - PubMed
  4. J Hematol Oncol. 2018 May 18;11(1):67 - PubMed
  5. Nat Rev Drug Discov. 2014 Jul;13(7):513-32 - PubMed
  6. Cell. 2012 Jun 8;149(6):1192-205 - PubMed
  7. Am J Physiol Cell Physiol. 2015 Oct 15;309(8):C511-21 - PubMed
  8. J Cell Biochem. 2017 Aug;118(8):1979-1983 - PubMed
  9. Arch Biochem Biophys. 1978 Jan 30;185(2):584-91 - PubMed
  10. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W363-7 - PubMed
  11. Crit Rev Biochem Mol Biol. 2017 Jun;52(3):327-339 - PubMed
  12. Bioinformation. 2009 Jun 13;3(9):384-8 - PubMed
  13. Bioessays. 1999 Dec;21(12):1021-30 - PubMed
  14. Leukemia. 2009 Sep;23(9):1658-66 - PubMed

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