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Beydoun MA, Beydoun HA, Weiss J, et al. Helicobacter pylori, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer's disease dementia in a large national survey. Mol Psychiatry. 2020;doi: 10.1038/s41380-020-0736-2.
Beydoun, M. A., Beydoun, H. A., Weiss, J., Hossain, S., El-Hajj, Z. W., & Zonderman, A. B. (2020). Helicobacter pylori, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer's disease dementia in a large national survey. Molecular psychiatry, . https://doi.org/10.1038/s41380-020-0736-2
Beydoun, May A, et al. "Helicobacter pylori, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer's disease dementia in a large national survey." Molecular psychiatry vol. (2020). doi: https://doi.org/10.1038/s41380-020-0736-2
Beydoun MA, Beydoun HA, Weiss J, Hossain S, El-Hajj ZW, Zonderman AB. Helicobacter pylori, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer's disease dementia in a large national survey. Mol Psychiatry. 2020 May 04; doi: 10.1038/s41380-020-0736-2. Epub 2020 May 04. PMID: 32366948.
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Mol Psychiatry. 2020 May 04; doi: 10.1038/s41380-020-0736-2. Epub 2020 May 04.

Helicobacter pylori, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer's disease dementia in a large national survey.

Molecular psychiatry

May A Beydoun, Hind A Beydoun, Jordan Weiss, Sharmin Hossain, Ziad W El-Hajj, Alan B Zonderman

Affiliations

  1. Laboratory of Epidemiology and Population Sciences, National Institutes on Aging, NIA/NIH/IRP, Baltimore, MD, USA. [email protected].
  2. Fort Belvoir Community Hospital, Fort Belvoir, VA, USA.
  3. Population Studies Center and the Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.
  4. Laboratory of Epidemiology and Population Sciences, National Institutes on Aging, NIA/NIH/IRP, Baltimore, MD, USA.
  5. McGill University, Montreal, QC, Canada.

PMID: 32366948 DOI: 10.1038/s41380-020-0736-2

Abstract

Co-infection between Helicobacter pylori (Hp) and groups of periodontal pathogens may alter the onset of Alzheimer's disease (AD) and all-cause dementia. We examined the interactive associations among Hp sero-positivity, periodontal disease (Pd), and infections with incident AD and all-cause dementia, among older adults (≥65 years at baseline). Up to 1431 participants from phase 1 of the National Health and Nutrition Survey III (1988-1991) had complete data till January 1st, 2014 on Hp sero-positivity with a mean follow-up of 10-11 years for AD and all-cause dementia incidence. Exposures consisted of 19 periodontal pathogens, constructed factors and clusters, and two Pd markers- probing depth and clinical attachment loss (CAL). Cox proportional hazards models were performed. Around 55% of the selected sample was Hp

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