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Zhvania MG, Pochkidze N. Neuronal Porosome Complex: Secretory Machinery at the Nerve Terminal. Discoveries (Craiova). 2017;5(3):e77doi: 10.15190/d.2017.7.
Zhvania, M. G., & Pochkidze, N. (2017). Neuronal Porosome Complex: Secretory Machinery at the Nerve Terminal. Discoveries (Craiova, Romania), 5(3), e77. https://doi.org/10.15190/d.2017.7
Zhvania, Mzia G, and Pochkidze, Nino. "Neuronal Porosome Complex: Secretory Machinery at the Nerve Terminal." Discoveries (Craiova, Romania) vol. 5,3 (2017): e77. doi: https://doi.org/10.15190/d.2017.7
Zhvania MG, Pochkidze N. Neuronal Porosome Complex: Secretory Machinery at the Nerve Terminal. Discoveries (Craiova). 2017 Jul 28;5(3):e77. doi: 10.15190/d.2017.7. PMID: 32309595; PMCID: PMC6941571.
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Discoveries (Craiova). 2017 Jul 28;5(3):e77. doi: 10.15190/d.2017.7.

Neuronal Porosome Complex: Secretory Machinery at the Nerve Terminal.

Discoveries (Craiova, Romania)

Mzia G Zhvania, Nino Pochkidze

Affiliations

  1. Institute of Chemical Biology, Ilia State University, 3/5 K. Cholokhashvili Avenue, 0162, Tbilisi, Georgia.
  2. Department of Brain Ultrastructure and Nanoarchitecture, I. Beriitashvili Center of Experimental BioMedicine, 14, Gotua Street, 0160 Tbilisi, Georgia.

PMID: 32309595 PMCID: PMC6941571 DOI: 10.15190/d.2017.7

Abstract

Neuronal porosomes are 15 nm cup-shaped lipoprotein secretory machines composed of nearly 30 proteins present at the presynaptic membrane, that have been investigated using multiple imaging modalities, such as electron microscopy, atomic force microscopy, and solution X-ray. Synaptic vesicles transiently dock and fuse at the base of the porosome cup facing the cytosol, by establishing a fusion pore for neurotransmitter release. Studies on the morphology, dynamics, isolation, composition, and reconstitution of the neuronal porosome complex provide a molecular understanding of its structure and function. In the past twenty years, a large body of evidence has accumulated on the involvement of the neuronal porosome proteins in neurotransmission and various neurological disorders. In light of these findings, this review briefly summarizes our current understanding of the neuronal porosome complex, the secretory nanomachine at the nerve terminal.

Copyright © 2017, Applied Systems.

Keywords: Neuronal porosome complex; neurotransmission; porosome proteins; synaptic vesicle volume

Conflict of interest statement

Conflict of interests: The authors have no conflicts of interest to report.

References

  1. J Cell Biol. 1992 Dec;119(6):1395-404 - PubMed
  2. Annu Rev Physiol. 1990;52:607-24 - PubMed
  3. Neuroscience. 1999;91(4):1435-44 - PubMed
  4. Neuropathol Appl Neurobiol. 2015 Jun;41(4):533-43 - PubMed
  5. Am J Physiol. 1988 Jan;254(1 Pt 1):G93-9 - PubMed
  6. J Gen Physiol. 1991 Oct;98(4):771-90 - PubMed
  7. Neuroscience. 2009 Aug 18;162(2):383-95 - PubMed
  8. Ultramicroscopy. 2006 Jun-Jul;106(8-9):674-7 - PubMed
  9. Brain Res. 1985 May 13;334(1):47-58 - PubMed
  10. Brain Res. 1999 Aug 14;838(1-2):37-44 - PubMed
  11. Cell Biol Int. 2004;28(1):19-31 - PubMed
  12. Funct Neurol. 2010 Jul-Sep;25(3):153-8 - PubMed
  13. J Physiol. 2007 Feb 15;579(Pt 1):85-99 - PubMed
  14. J Cell Biol. 1973 May;57(2):499-524 - PubMed
  15. J Membr Biol. 1992 Sep;129(3):253-66 - PubMed
  16. Exp Biol Med (Maywood). 2005 Oct;230(9):674-80 - PubMed
  17. J Am Chem Soc. 2010 Apr 28;132(16):5596-7 - PubMed
  18. Science. 1992 Jul 10;257(5067):255-9 - PubMed
  19. J Am Chem Soc. 2005 Jul 27;127(29):10156-7 - PubMed
  20. Micron. 2012 Sep;43(9):948-53 - PubMed
  21. Endocrinology. 2016 Jan;157(1):54-60 - PubMed
  22. J Neurosci Res. 2010 Jan;88(1):95-101 - PubMed
  23. Science. 2011 Mar 4;331(6021):1192-5 - PubMed
  24. Biophys J. 2003 Sep;85(3):2035-43 - PubMed
  25. ScientificWorldJournal. 2009 Dec 16;9:1463-75 - PubMed
  26. Pflugers Arch. 1989 Feb;413(4):385-94 - PubMed
  27. Cereb Cortex. 2014 Feb;24(2):364-76 - PubMed
  28. Nature. 1993 Jun 10;363(6429):497-8 - PubMed
  29. Biochem J. 1990 Nov 15;272(1):119-26 - PubMed
  30. J Am Chem Soc. 2006 Jan 11;128(1):26-7 - PubMed
  31. Brain Res. 1999 Jul 10;834(1-2):66-73 - PubMed
  32. Biophys J. 1991 May;59(5):1022-7 - PubMed
  33. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4720-4 - PubMed
  34. Micron. 2013 Jan;44:137-42 - PubMed
  35. Biophys J. 1991 Jan;59(1):39-47 - PubMed
  36. Cell Biol Int. 2004;28(10):699-708 - PubMed
  37. Ann N Y Acad Sci. 2002 Oct;971:254-6 - PubMed
  38. J Cell Mol Med. 2011 Mar;15(3):572-6 - PubMed
  39. Cell Motil Cytoskeleton. 2000 Feb;45(2):106-20 - PubMed
  40. Annu Rev Physiol. 1986;48:175-89 - PubMed
  41. Chem Phys Lett. 2008 Sep 1;462(1-3):6-9 - PubMed
  42. J Cell Biol. 1989 Dec;109(6 Pt 1):3039-52 - PubMed
  43. Electrophoresis. 1999 Apr-May;20(4-5):928-34 - PubMed
  44. J Neurocytol. 2001 Apr;30(4):281-92 - PubMed
  45. J Neurochem. 2010 Feb;112(4):991-1004 - PubMed
  46. Cell Biol Int. 2004;28(10):709-16 - PubMed
  47. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4538-42 - PubMed
  48. Biophys J. 2003 Feb;84(2 Pt 1):1337-43 - PubMed
  49. J Proteomics. 2012 Jul 16;75(13):3952-62 - PubMed
  50. J Cell Mol Med. 2011 Jan;15(1):31-7 - PubMed
  51. Am J Physiol. 1993 May;264(5 Pt 1):G895-901 - PubMed
  52. J Biol Chem. 2013 Jul 19;288(29):20966-77 - PubMed
  53. Biophys J. 2002 Nov;83(5):2522-7 - PubMed
  54. Cell Biol Int Rep (2010). 2011;18(1): - PubMed
  55. J Phys Chem B. 2010 Oct 21;114(41):13249-54 - PubMed
  56. Nature. 1998 Sep 24;395(6700):347-53 - PubMed
  57. Nature. 2003 Jun 5;423(6940):643-7 - PubMed
  58. Eur J Biochem. 1991 Apr 23;197(2):391-8 - PubMed
  59. Pflugers Arch. 1989 Oct;415(1):29-36 - PubMed
  60. J Neurosci. 2013 Aug 28;33(35):14269-81 - PubMed
  61. J Biol Chem. 1996 Feb 9;271(6):3300-5 - PubMed
  62. J Physiol. 2000 Jun 15;525 Pt 3:579-86 - PubMed
  63. Eur J Neurosci. 2007 Aug;26(3):547-59 - PubMed
  64. Science. 1998 Apr 24;280(5363):602-5 - PubMed
  65. Endocrinology. 2002 Mar;143(3):1144-8 - PubMed
  66. Cell. 1998 Mar 20;92(6):759-72 - PubMed
  67. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3125-30 - PubMed
  68. Neuron. 1990 Jun;4(6):813-8 - PubMed
  69. Exp Biol Med (Maywood). 2010 Apr;235(4):470-7 - PubMed
  70. Nature. 1993 Jun 10;363(6429):554-8 - PubMed
  71. Neurosci Lett. 1997 Mar 14;224(2):127-30 - PubMed
  72. Eur J Neurosci. 2007 Jan;25(1):159-67 - PubMed
  73. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13317-22 - PubMed
  74. J Biol Chem. 2001 May 18;276(20):17584-90 - PubMed
  75. Am J Physiol. 1990 Sep;259(3 Pt 1):C413-20 - PubMed
  76. J Biochem Mol Biol. 2007 May 31;40(3):302-14 - PubMed
  77. J Cell Biol. 2002 Sep 2;158(5):915-27 - PubMed
  78. Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):316-21 - PubMed
  79. Neuron. 1999 Jul;23(3):593-605 - PubMed
  80. Annu Rev Physiol. 1986;48:163-74 - PubMed
  81. Micron. 2014 Jan;56:37-43 - PubMed

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