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Khammy MM, Angus JA, Wright CE. Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature. Heliyon. 2020;6(4):e03810doi: 10.1016/j.heliyon.2020.e03810.
Khammy, M. M., Angus, J. A., & Wright, C. E. (2020). Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature. Heliyon, 6(4), e03810. https://doi.org/10.1016/j.heliyon.2020.e03810
Khammy, Makhala M, et al. "Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature." Heliyon vol. 6,4 (2020): e03810. doi: https://doi.org/10.1016/j.heliyon.2020.e03810
Khammy MM, Angus JA, Wright CE. Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature. Heliyon. 2020 Apr 23;6(4):e03810. doi: 10.1016/j.heliyon.2020.e03810. eCollection 2020 Apr. PMID: 32368652; PMCID: PMC7184177.
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Heliyon. 2020 Apr 23;6(4):e03810. doi: 10.1016/j.heliyon.2020.e03810. eCollection 2020 Apr.

Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature.

Heliyon

Makhala M Khammy, James A Angus, Christine E Wright

Affiliations

  1. Cardiovascular Therapeutics Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia.

PMID: 32368652 PMCID: PMC7184177 DOI: 10.1016/j.heliyon.2020.e03810

Abstract

OBJECTIVES: The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vascular amplifier hypertensive:normotensive (H:N) ratio in the renal bed compared with the total peripheral bed in conscious rabbits during infusion of vasoconstrictor and vasodilator stimuli.

METHODS: Rabbits were subjected to bilateral renal cellophane wrap or sham operation. A perivascular ultrasonic flow probe was implanted on the left renal artery to measure renal blood flow. A catheter was inserted into the thoracic aorta for agonist administration. Blood pressure, heart rate and renal blood flow were measured on three separate days in conscious rabbits with intact effectors, ganglionic block or neurohumoral block. Dose-response curves were constructed to intra-arterial infusion of noradrenaline, angiotensin II, adenosine and acetylcholine.

RESULTS: Resting renal vascular resistance in hypertensive rabbits was markedly decreased by ganglionic block and further by neurohumoral block. With effectors intact, ganglionic block or neurohumoral block, the H:N ratio for renal vascular resistance was 2.32, 1.72 or 1.72, respectively. The ratio was generally maintained during the infusion of constrictor and dilator drugs although distortions occurred at higher concentrations of constrictor or dilator drugs.

CONCLUSIONS: Estimation of the renal resistance amplifier in renal wrap hypertension with neurohumoral block accords with our earlier estimates of the total peripheral resistance amplifier (1.79). This vascular resistance amplifier is consistent with a decrease in internal radius through structural remodelling in the renal vascular bed as is reflected in the total arterial circulation in hypertension.

© 2020 The Author(s).

Keywords: Acetylcholine; Adenosine; Angiotensin II; Cellophane wrap hypertension; Dose-response relationship; Ganglionic block; Neurohumoral block; Noradrenaline; Pathophysiology; Pharmacology; Physiology; Renal system; Renal vascular bed; Vascular resistance amplifier; Zoology

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