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Dong J, Breitenborn H, Piccoli R, et al. Terahertz three-dimensional monitoring of nanoparticle-assisted laser tissue soldering. Biomed Opt Express. 2020;11(4):2254-2267doi: 10.1364/BOE.389561.
Dong, J., Breitenborn, H., Piccoli, R., Besteiro, L. V., You, P., Caraffini, D., Wang, Z. M., Govorov, A. O., Naccache, R., Vetrone, F., Razzari, L., & Morandotti, R. (2020). Terahertz three-dimensional monitoring of nanoparticle-assisted laser tissue soldering. Biomedical optics express, 11(4), 2254-2267. https://doi.org/10.1364/BOE.389561
Dong, Junliang, et al. "Terahertz three-dimensional monitoring of nanoparticle-assisted laser tissue soldering." Biomedical optics express vol. 11,4 (2020): 2254-2267. doi: https://doi.org/10.1364/BOE.389561
Dong J, Breitenborn H, Piccoli R, Besteiro LV, You P, Caraffini D, Wang ZM, Govorov AO, Naccache R, Vetrone F, Razzari L, Morandotti R. Terahertz three-dimensional monitoring of nanoparticle-assisted laser tissue soldering. Biomed Opt Express. 2020 Mar 27;11(4):2254-2267. doi: 10.1364/BOE.389561. eCollection 2020 Apr 01. PMID: 32341881; PMCID: PMC7173899.
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Biomed Opt Express. 2020 Mar 27;11(4):2254-2267. doi: 10.1364/BOE.389561. eCollection 2020 Apr 01.

Terahertz three-dimensional monitoring of nanoparticle-assisted laser tissue soldering.

Biomedical optics express

Junliang Dong, Holger Breitenborn, Riccardo Piccoli, Lucas V Besteiro, Pei You, Diego Caraffini, Zhiming M Wang, Alexander O Govorov, Rafik Naccache, Fiorenzo Vetrone, Luca Razzari, Roberto Morandotti

Affiliations

  1. Institut National de la Recherche Scientifique (INRS), Centre Énergie, Matériaux et Télécommunications (EMT), Varennes, QC J3X 1S2, Canada.
  2. [email protected].
  3. Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China.
  4. Department of Physics and Astronomy, Ohio University, Athens, Ohio 45701, USA.
  5. Department of Chemistry and Biochemistry and Centre for NanoScience Research, Concordia University, Montreal, QC H4B 1R6, Canada.
  6. Quebec Centre for Advanced Materials, Department of Chemistry and Biochemistry, Concordia University, Montreal, QC H4B 1R6, Canada.
  7. [email protected].

PMID: 32341881 PMCID: PMC7173899 DOI: 10.1364/BOE.389561

Abstract

In view of minimally-invasive clinical interventions, laser tissue soldering assisted by plasmonic nanoparticles is emerging as an appealing concept in surgical medicine, holding the promise of surgeries without sutures. Rigorous monitoring of the plasmonically-heated solder and the underlying tissue is crucial for optimizing the soldering bonding strength and minimizing the photothermal damage. To this end, we propose a non-invasive, non-contact, and non-ionizing modality for monitoring nanoparticle-assisted laser-tissue interaction and visualizing the localized photothermal damage, by taking advantage of the unique sensitivity of terahertz radiation to the hydration level of biological tissue. We demonstrate that terahertz radiation can be employed as a versatile tool to reveal the thermally-affected evolution in tissue, and to quantitatively characterize the photothermal damage induced by nanoparticle-assisted laser tissue soldering in three dimensions. Our approach can be easily extended and applied across a broad range of clinical applications involving laser-tissue interaction, such as laser ablation and photothermal therapies.

© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.

Conflict of interest statement

The authors declare no conflicts of interest.

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