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E Eleraky N, M Omar M, A Mahmoud H, et al. Nanostructured Lipid Carriers to Mediate Brain Delivery of Temazepam: Design and In Vivo Study. Pharmaceutics. 2020;12(5)doi: 10.3390/pharmaceutics12050451.
E Eleraky, N., M Omar, M., A Mahmoud, H., & A Abou-Taleb, H. (2020). Nanostructured Lipid Carriers to Mediate Brain Delivery of Temazepam: Design and In Vivo Study. Pharmaceutics, 12(5), . https://doi.org/10.3390/pharmaceutics12050451
E Eleraky, Nermin, et al. "Nanostructured Lipid Carriers to Mediate Brain Delivery of Temazepam: Design and In Vivo Study." Pharmaceutics vol. 12,5 (2020). doi: https://doi.org/10.3390/pharmaceutics12050451
E Eleraky N, M Omar M, A Mahmoud H, A Abou-Taleb H. Nanostructured Lipid Carriers to Mediate Brain Delivery of Temazepam: Design and In Vivo Study. Pharmaceutics. 2020 May 14;12(5). doi: 10.3390/pharmaceutics12050451. PMID: 32422903; PMCID: PMC7284889.
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Pharmaceutics. 2020 May 14;12(5). doi: 10.3390/pharmaceutics12050451.

Nanostructured Lipid Carriers to Mediate Brain Delivery of Temazepam: Design and In Vivo Study.

Pharmaceutics

Nermin E Eleraky, Mahmoud M Omar, Hemat A Mahmoud, Heba A Abou-Taleb

Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
  2. Department of Pharmaceutics and Industrial Pharmacy, Deraya University, Minia 61768, Egypt.
  3. Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.
  4. Department of Clinical Oncology and Nuclear Medicine, Assiut University, Assiut 71526, Egypt.
  5. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef 62511, Egypt.

PMID: 32422903 PMCID: PMC7284889 DOI: 10.3390/pharmaceutics12050451

Abstract

The opposing effect of the blood-brain barrier against the delivery of most drugs warrants the need for an efficient brain targeted drug delivery system for the successful management of neurological disorders. Temazepam-loaded nanostructured lipid carriers (NLCs) have shown possibilities for enhancing bioavailability and brain targeting affinity after oral administration. This study aimed to investigate these properties for insomnia treatment. Temazepam-NLCs were prepared by the solvent injection method and optimized using a 4

Keywords: brain delivery; factorial design; lipid nanoparticles; nanostructured lipid carriers

References

  1. Int J Pharm Investig. 2015 Oct-Dec;5(4):182-91 - PubMed
  2. Adv Drug Deliv Rev. 2014 May;71:2-14 - PubMed
  3. AAPS PharmSciTech. 2012 Mar;13(1):150-8 - PubMed
  4. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):859-71 - PubMed
  5. J Pharm Pharmacol. 2017 Aug;69(8):955-966 - PubMed
  6. Int J Nanomedicine. 2018 Dec 21;14:119-133 - PubMed
  7. Daru. 2015 Sep 21;23:46 - PubMed
  8. J Pharm Sci. 2011 Feb;100(2):743-57 - PubMed
  9. AAPS PharmSciTech. 2014 Dec;15(6):1509-15 - PubMed
  10. Br J Anaesth. 1987 Apr;59(4):465-7 - PubMed
  11. J Funct Biomater. 2018 Jan 18;9(1): - PubMed
  12. AAPS PharmSciTech. 2010 Dec;11(4):1684-94 - PubMed
  13. J Control Release. 2006 Aug 10;114(1):53-9 - PubMed
  14. Lancet Neurol. 2013 Jan;12(1):31-2 - PubMed
  15. Nat Rev Drug Discov. 2011 Jul 29;10(9):685-97 - PubMed
  16. Res Pharm Sci. 2019 Aug;14(4):293-307 - PubMed
  17. Int J Pharm. 2010 Jul 15;394(1-2):179-85 - PubMed
  18. Pharmaceutics. 2018 May 18;10(2): - PubMed
  19. Nanoscale Res Lett. 2018 Oct 15;13(1):323 - PubMed
  20. Acta Pharm. 2015 Mar;65(1):1-13 - PubMed
  21. Drug Deliv. 2016 May;23(4):1383-92 - PubMed
  22. Int J Nanomedicine. 2014 May 02;9:2117-26 - PubMed
  23. Int J Nanomedicine. 2012;7:4581-91 - PubMed
  24. AAPS PharmSciTech. 2015 Oct;16(5):1108-21 - PubMed
  25. J Drug Target. 2012 Dec;20(10):813-30 - PubMed
  26. Drug Dev Ind Pharm. 2010 May;36(5):508-17 - PubMed
  27. J Pharm Sci. 1994 Nov;83(11):1543-7 - PubMed
  28. J Cereb Blood Flow Metab. 2012 Nov;32(11):1959-72 - PubMed
  29. Colloids Surf B Biointerfaces. 2011 Nov 1;88(1):483-9 - PubMed
  30. Maturitas. 2012 Sep;73(1):45-51 - PubMed
  31. Int J Nanomedicine. 2016 Oct 05;11:5067-5077 - PubMed
  32. Pharmaceutics. 2019 May 08;11(5): - PubMed
  33. AAPS J. 2008;10(1):166-77 - PubMed
  34. Drug Des Devel Ther. 2019 Dec 27;13:4413-4430 - PubMed
  35. Acta Biomater. 2019 May;90:350-361 - PubMed
  36. Theranostics. 2018 Feb 5;8(6):1481-1493 - PubMed
  37. Int J Pharm. 2019 Jan 10;554:352-365 - PubMed
  38. Adv Pharm Bull. 2014 Dec;4(Suppl 2):563-8 - PubMed
  39. Int J Pharm. 2007 Jan 10;328(2):191-5 - PubMed
  40. J Colloid Interface Sci. 2016 Feb 1;463:258-65 - PubMed
  41. Pharm World Sci. 1996 Jun;18(3):114-9 - PubMed
  42. Int J Pharm. 2000 Apr 20;199(2):167-77 - PubMed
  43. Colloids Surf B Biointerfaces. 2020 Mar;187:110649 - PubMed
  44. Int J Pharm. 2002 Dec 5;249(1-2):45-58 - PubMed
  45. Int J Pharm. 2020 Mar 15;577:119033 - PubMed
  46. Int J Pharm. 2012 Feb 28;423(2):461-70 - PubMed
  47. Int J Mol Sci. 2014 Jan 24;15(2):1812-25 - PubMed
  48. Drug Deliv. 2016 Jul;23(6):1912-25 - PubMed
  49. Int J Pharm. 2009 Feb 9;367(1-2):187-94 - PubMed
  50. Biomed Res Int. 2015;2015:484963 - PubMed
  51. Nanotechnology. 2010 Jan 15;21(2):025101 - PubMed
  52. Pharmaceutics. 2019 Feb 25;11(2): - PubMed
  53. Br J Anaesth. 1991 Jan;66(1):20-4 - PubMed
  54. Int J Pharm. 2003 Jul 9;260(1):47-57 - PubMed
  55. J Colloid Interface Sci. 2002 Jul 15;251(2):360-5 - PubMed
  56. Ochsner J. 2013 Summer;13(2):214-23 - PubMed
  57. Biomed Pharmacother. 2018 Jul;103:598-613 - PubMed
  58. J Pharm Sci. 2019 Oct;108(10):3382-3395 - PubMed
  59. Int J Nanomedicine. 2016 Jun 14;11:2829-38 - PubMed
  60. J Pharm Bioallied Sci. 2013 Oct;5(4):290-7 - PubMed
  61. Nutrients. 2019 Jan 01;11(1): - PubMed
  62. ISRN Biochem. 2013 May 21;2013:238428 - PubMed
  63. Fluids Barriers CNS. 2017 Jul 13;14(1):19 - PubMed
  64. Drug Deliv. 2016 May;23(4):1486-94 - PubMed
  65. J Microencapsul. 2006 Jun;23(4):417-33 - PubMed
  66. J Drug Target. 2005 Jun;13(5):317-24 - PubMed
  67. BMC Neurol. 2009 Jun 12;9 Suppl 1:S3 - PubMed
  68. Nature. 1999 Oct 21;401(6755):796-800 - PubMed
  69. J Control Release. 2013 Mar 10;166(2):115-23 - PubMed
  70. Pharmaceutics. 2019 Dec 14;11(12): - PubMed
  71. Curr Med Chem. 2011;18(34):5303-21 - PubMed
  72. Iran J Pharm Res. 2018 Fall;17(4):1209-1216 - PubMed
  73. Acta Pharm Sin B. 2016 Jul;6(4):268-86 - PubMed
  74. J Drug Target. 2004;12(9-10):635-41 - PubMed
  75. Int J Pharm. 2007 May 24;336(2):248-56 - PubMed
  76. Drug Deliv. 2018 Nov;25(1):1910-1921 - PubMed
  77. Chem Phys Lipids. 2018 Nov;216:65-72 - PubMed
  78. Int J Nanomedicine. 2019 Jul 11;14:5073-5085 - PubMed
  79. ACS Nano. 2014 May 27;8(5):4304-12 - PubMed
  80. J Drug Target. 2002 Jun;10(4):285-96 - PubMed

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