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Ng YM, Mat Yusuf SNA, Chiu HI, et al. Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation. Pharmaceutics. 2020;12(5)doi: 10.3390/pharmaceutics12050461.
Ng, Y. M., Mat Yusuf, S. N. A., Chiu, H. I., & Lim, V. (2020). Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation. Pharmaceutics, 12(5), . https://doi.org/10.3390/pharmaceutics12050461
Ng, Yoke Mooi, et al. "Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation." Pharmaceutics vol. 12,5 (2020). doi: https://doi.org/10.3390/pharmaceutics12050461
Ng YM, Mat Yusuf SNA, Chiu HI, Lim V. Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation. Pharmaceutics. 2020 May 18;12(5). doi: 10.3390/pharmaceutics12050461. PMID: 32443633; PMCID: PMC7284438.
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Pharmaceutics. 2020 May 18;12(5). doi: 10.3390/pharmaceutics12050461.

Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation.

Pharmaceutics

Yoke Mooi Ng, Siti Nur Aishah Mat Yusuf, Hock Ing Chiu, Vuanghao Lim

Affiliations

  1. Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, Penang, Malaysia.
  2. Department of Chemical Engineering Technology, Faculty of Engineering Technology, Universiti Malaysia Perlis, UniCITI Alam Campus, Padang Besar 02100, Perlis, Malaysia.

PMID: 32443633 PMCID: PMC7284438 DOI: 10.3390/pharmaceutics12050461

Abstract

Cystamine-based polymers may help to achieve controlled and targeted drug delivery to the colon due to their susceptibility to breakage of the disulfide linkage in the low redox potential environment of the colon. In this study, two linear cystamine-based polymers with similar repeating units (LP1 and LP2) and a cross-linked cystamine-based polymer (BP) were synthesised and their kinetics and the various physical conditions underlying cystamine-based polymerisation were evaluated. In brief,

Keywords: crosslinked; cystamine; cysteamine; disulfide; linear; redox-sensitive; thiol

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