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Alam U, Petropoulos IN, Ponirakis G, et al. Vitamin D deficiency is associated with painful diabetic neuropathy. Diabetes Metab Res Rev. 2020;37(1):e3361doi: 10.1002/dmrr.3361.
Alam, U., Petropoulos, I. N., Ponirakis, G., Ferdousi, M., Asghar, O., Jeziorska, M., Marshall, A., Boulton, A. J. M., Efron, N., & Malik, R. A. (2021). Vitamin D deficiency is associated with painful diabetic neuropathy. Diabetes/metabolism research and reviews, 37(1), e3361. https://doi.org/10.1002/dmrr.3361
Alam, Uazman, et al. "Vitamin D deficiency is associated with painful diabetic neuropathy." Diabetes/metabolism research and reviews vol. 37,1 (2021): e3361. doi: https://doi.org/10.1002/dmrr.3361
Alam U, Petropoulos IN, Ponirakis G, Ferdousi M, Asghar O, Jeziorska M, Marshall A, Boulton AJM, Efron N, Malik RA. Vitamin D deficiency is associated with painful diabetic neuropathy. Diabetes Metab Res Rev. 2021 Jan;37(1):e3361. doi: 10.1002/dmrr.3361. Epub 2020 Jul 09. PMID: 32506740.
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Diabetes Metab Res Rev. 2021 Jan;37(1):e3361. doi: 10.1002/dmrr.3361. Epub 2020 Jul 09.

Vitamin D deficiency is associated with painful diabetic neuropathy.

Diabetes/metabolism research and reviews

Uazman Alam, Ioannis N Petropoulos, Georgios Ponirakis, Maryam Ferdousi, Omar Asghar, Maria Jeziorska, Andrew Marshall, Andrew J M Boulton, Nathan Efron, Rayaz A Malik

Affiliations

  1. Department of Cardiovascular & Metabolic Medicine and the Pain Research Institute, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
  2. Department of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  3. Weill Cornell Medicine-Qatar, Research Division, Qatar Foundation, Doha, Qatar.
  4. Institute of Cardiovascular Sciences, Cardiac Centre, Faculty of Medical and Human Sciences, University of Manchester and NIHR Clinical Research Facility, Manchester, UK.
  5. Pain Research Institute, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
  6. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

PMID: 32506740 DOI: 10.1002/dmrr.3361

Abstract

BACKGROUND: The aetiology of painful diabetic neuropathy is unclear. We have evaluated vitamin D levels in diabetic patients with and without painful neuropathy.

METHODS: Forty-three patients with type 1 diabetes and painless (DPN) (n = 20) or painful (PDN) (n = 23) neuropathy and 14 non-diabetic healthy control subjects (C) underwent assessment of neurologic deficits, quantitative sensory testing (QST), electrophysiology, skin biopsy, corneal confocal microscopy (CCM) and measurement of serum 25(OH)D.

RESULTS: There were no significant differences for age, BMI, HbA

CONCLUSIONS: This study suggests that vitamin D deficiency and insufficiency are associated with painful diabetic neuropathy.

© 2020 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.

Keywords: Painful neuropathy; diabetic neuropathy; small fibre neuropathy; vitamin D

References

  1. Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care. 2011;34(10):2220-2224. - PubMed
  2. Almuhannadi H, Ponirakis G, Khan A, Malik RA. Diabetic neuropathy and painful diabetic neuropathy: Cinderella complications in South East Asia. J Pak Med Assoc. 2018;68(1):85-89. - PubMed
  3. Ponirakis G, Elhadd T, Chinnaiyan S, et al. Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar. J Diabetes Investig. 2019;10(6):1558-1564. - PubMed
  4. Abbott CA, Malik RA, van Ross ERE, Kulkarni J, Boulton AJM. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the UK. Diabetes Care. 2011;34(10):2220-2224. - PubMed
  5. Tesfaye S, Vileikyte L, Rayman G, et al. Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management. Diabetes Metab Res Rev. 2011;27:629-638. - PubMed
  6. Sadosky A, Schaefer C, Mann R, et al. Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey. Diabetes Metab Syndr Obes. 2013;6:79-92. - PubMed
  7. Soderstrom LH, Johnson SP, Diaz VA, Mainous AG 3rd. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES. Diabet Med. 2012;29(1):50-55. - PubMed
  8. Shehab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA. Does vitamin D deficiency play a role in peripheral neuropathy in type 2 diabetes? Diabet Med. 2012;29(1):43-49. - PubMed
  9. Alamdari A, Mozafari R, Tafakhori A, et al. An inverse association between serum vitamin D levels with the presence and severity of impaired nerve conduction velocity and large fiber peripheral neuropathy in diabetic subjects. Neurol Sci. 2015;36(7):1121-1126. - PubMed
  10. Maser R, Lenhard M, Pohlig R. Vitamin D insufficiency is associated with reduced parasympathetic nerve fiber function in type 2 diabetes. Endocr Pract. 2015;21(2):174-181. - PubMed
  11. Hansen CS, Fleischer J, Vistisen D, Ridderstrale M, Jensen JS, Jorgensen ME. High and low vitamin D level is associated with cardiovascular autonomic neuropathy in people with type 1 and type 2 diabetes. Diabet Med. 2017;34(3):364-371. - PubMed
  12. Qu G-B, Wang L-L, Tang X, Wu W, Sun Y-H. The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: an update systematic review and meta-analysis. J Clin Trans Endocrinol. 2017;9:25-31. - PubMed
  13. Zambelis T, Papadakis G, Kokotis P, Villiotou V, Dogkas N, Karandreas N. Lack of definite Association of Vitamin D Deficiency with diabetic neuropathy. Investigation in Greek and in Bangladeshi patients. In Vivo (Athens, Greece). 2017;31(2):259-261. - PubMed
  14. Shillo P, Selvarajah D, Greig M, et al. Reduced vitamin D levels in painful diabetic peripheral neuropathy. Diabet Med. 2019;36(1):44-51. - PubMed
  15. Tague SE, Smith PG. Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: modulation by ovarian hormones. J Chem Neuroanat. 2011;41(1):1-12. - PubMed
  16. Tague SE, Clarke GL, Winter MK, McCarson KE, Wright DE, Smith PG. Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation. J Neurosci. 2011;31(39):13728-13738. - PubMed
  17. Hellweg R, Wohrle M, Hartung HD, Stracke H, Hock C, Federlin K. Diabetes mellitus-associated decrease in nerve growth factor levels is reversed by allogeneic pancreatic islet transplantation. Neurosci Lett. 1991;125(1):1-4. - PubMed
  18. Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I. Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes. Skin Pharmacol Appl Skin Physiol. 2001;14(4):226-233. - PubMed
  19. Wergeland S, Torkildsen O, Myhr KM, Aksnes L, Mork SJ, Bo L. Dietary vitamin D3 supplements reduce demyelination in the cuprizone model. PLoS One. 2011;6(10):e26262. - PubMed
  20. Bianco J, Gueye Y, Marqueste T, et al. Vitamin D(3) improves respiratory adjustment to fatigue and H-reflex responses in paraplegic adult rats. Neuroscience. 2011;188:182-192. - PubMed
  21. Shehab D, Al-Jarallah K, Abdella N, Mojiminiyi OA, Al MH. Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus. Med Princ Pract. 2015;24(3):250-256. - PubMed
  22. Nadi M, Marandi SM, Esfarjani F, Saleki M, Mohammadi M. The comparison between effects of 12 weeks combined training and vitamin D supplement on improvement of sensory-motor neuropathy in type 2 diabetic women. Adv Biomed Res. 2017;6:55. - PubMed
  23. Basit A, Basit KA, Fawwad A, et al. Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Res Care. 2016;4(1):e000148. - PubMed
  24. Alam U, Fawwad A, Shaheen F, Tahir B, Basit A, Malik RA. Improvement in neuropathy specific quality of life in patients with diabetes after vitamin D supplementation. J Diabetes Res. 2017;2017:7. - PubMed
  25. Bravenboer B, van Dam PS, Hop J, Vd Steenhoven J, Erkelens DW. Thermal threshold testing for the assessment of small fibre dysfunction: normal values and reproducibility. Diabet Med. 1992;9(6):546-549. - PubMed
  26. Petropoulos IN, Manzoor T, Morgan P, et al. Repeatability of in vivo corneal confocal microscopy to quantify corneal nerve morphology. Cornea. 2013;32(5):e83-e89. - PubMed
  27. Kalteniece A, Ferdousi M, Adam S, et al. Corneal confocal microscopy is a rapid reproducible ophthalmic technique for quantifying corneal nerve abnormalities. PLOS One. 2017;12(8):e0183040. - PubMed
  28. Tavakoli M, Malik RA. Corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. J Vis Exp. 2011;47:2194. - PubMed
  29. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202-207. - PubMed
  30. ASBMR. 31st annual meeting MO0001-MO0445. J Bone Miner Res. 2009;24(S1):S370-S496. - PubMed
  31. Rosen CJ, Gallagher JC. The 2011 IOM report on vitamin D and calcium requirements for north america: clinical implications for providers treating patients with low bone mineral density. J Clin Densitom. 2011;14(2):79-84. - PubMed
  32. Bril V, England J, Franklin GM, et al. Evidence-based guideline: treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of physical medicine and rehabilitation. Neurology. 2011;3(4):345-52.e21. - PubMed
  33. Selvarajah D, Gandhi R, Emery CJ, Tesfaye S. Randomized placebo-controlled double-blind clinical trial of cannabis-based medicinal product (Sativex) in painful diabetic neuropathy: depression is a major confounding factor. Diabetes Care. 2010;33(1):128-130. - PubMed
  34. Ziegler D, Hidvégi T, Gurieva I, et al. Efficacy and safety of Lacosamide in painful diabetic neuropathy. Diabetes Care. 2010;33(4):839-841. - PubMed
  35. Selvarajah D, Wilkinson ID, Gandhi R, Griffiths PD, Tesfaye S. Microvascular perfusion abnormalities of the thalamus in painful but not painless diabetic polyneuropathy: a clue to the pathogenesis of pain in type 1 diabetes. Diabetes Care. 2011;34(3):718-720. - PubMed
  36. Britland ST, Young RJ, Sharma AK, Clarke BF. Association of painful and painless diabetic polyneuropathy with different patterns of nerve fiber degeneration and regeneration. Diabetes. 1990;39(8):898-908. - PubMed
  37. Gandhi RA, Marques JL, Selvarajah D, Emery CJ, Tesfaye S. Painful diabetic neuropathy is associated with greater autonomic dysfunction than painless diabetic neuropathy. Diabetes Care. 2010;33(7):1585-1590. - PubMed
  38. Krishnan ST, Quattrini C, Jeziorska M, Malik RA, Rayman G. Abnormal LDIflare but normal quantitative sensory testing and dermal nerve fiber density in patients with painful diabetic neuropathy. Diabetes Care. 2009;32(3):451-455. - PubMed
  39. Quattrini C, Tavakoli M, Jeziorska M, et al. Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes. 2007;56(8):2148-2154. - PubMed
  40. Cheng HT, Dauch JR, Porzio MT, et al. Increased axonal regeneration and swellings in Intraepidermal nerve fibers characterize painful phenotypes of diabetic neuropathy. J Pain. 2013;14:941-947. - PubMed
  41. Kalteniece A, Ferdousi M, Petropoulos I, et al. Greater corneal nerve loss at the inferior whorl is related to the presence of diabetic neuropathy and painful diabetic neuropathy. Sci Rep. 2018;8(1):3283. - PubMed
  42. Alam U, Najam O, Al-Himdani S, et al. Marked vitamin D deficiency in patients with diabetes in the UK: ethnic and seasonal differences and an association with dyslipidaemia. Diabet Med. 2012;29(10):1343-1345. - PubMed
  43. Niu Y, Li J, Peng R, Zhao X, Wu J, Tang Q. Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle-aged patients. Diabetes Metab Res Rev. 2019;35(6):e3162. - PubMed
  44. Catalano A, Morabito N, Atteritano M, Basile G, Cucinotta D, Lasco A. Vitamin D reduces musculoskeletal pain after infusion of Zoledronic acid for postmenopausal osteoporosis. Calcif Tissue Int. 2012;90(4):279-285. - PubMed
  45. Straube S, Andrew Moore R, Derry S, McQuay HJ. Vitamin D and chronic pain. Pain. 2009;141(1-2):10-13. - PubMed
  46. Valensi P, Le Devehat C, Richard JL, et al. A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complications. 2005;19(5):247-253. - PubMed
  47. Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med. 2008;168(7):771-772. - PubMed
  48. Burstein R, Henry NJ, Collison ML, et al. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017. Nature. 2019;574(7778):353-358. - PubMed
  49. Anju M, Chacko L, Chettupalli Y, Maiya AG, Saleena UV. Effect of low level laser therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy-a pilot study. Diabetes Metab Syndr Clin Res Rev. 2019;13(2):1087-1091. - PubMed

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