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Int J Endocrinol. 2020 May 18;2020:9767926. doi: 10.1155/2020/9767926. eCollection 2020.

Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8.

International journal of endocrinology

Fengyun Wen, Qiao Xia, Hui Zhang, Haipeng Shia, Amin Rajesh, Yanling Wu, Yi Yang, Zaiqing Yang

Affiliations

  1. College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
  2. Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
  3. Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, 36849-5501 Auburn, Alabama, USA.

PMID: 32508919 PMCID: PMC7251471 DOI: 10.1155/2020/9767926

Abstract

Resistin is associated with metabolic syndrome and inflammatory conditions. Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear. Keratin 8 is a typical epithelial intermediate filament protein, but numerous studies suggest a vital role of K8 in glucose metabolism. However, it is still not known whether K8 participates in the mediation of resistin-induced reduction of cellular glycogen accumulation. In this study, we found that resistin upregulated expression of the p65 subunit of NF-

Copyright © 2020 Fengyun Wen et al.

Conflict of interest statement

No potential conflicts of interest relevant to this article were reported.

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