Display options
Cite
Moghaddam MJ, de Campo L, Hirabayashi M, et al. Gadolinium-DTPA amphiphile nanoassemblies: agents for magnetic resonance imaging and neutron capture therapy. Biomater Sci. 2014;2(6):924-935doi: 10.1039/c3bm60235d.
Moghaddam, M. J., de Campo, L., Hirabayashi, M., Bean, P. A., Waddington, L. J., Scoble, J. A., Coia, G., & Drummond, C. J. (2014). Gadolinium-DTPA amphiphile nanoassemblies: agents for magnetic resonance imaging and neutron capture therapy. Biomaterials science, 2(6), 924-935. https://doi.org/10.1039/c3bm60235d
Moghaddam, Minoo J, et al. "Gadolinium-DTPA amphiphile nanoassemblies: agents for magnetic resonance imaging and neutron capture therapy." Biomaterials science vol. 2,6 (2014): 924-935. doi: https://doi.org/10.1039/c3bm60235d
Moghaddam MJ, de Campo L, Hirabayashi M, Bean PA, Waddington LJ, Scoble JA, Coia G, Drummond CJ. Gadolinium-DTPA amphiphile nanoassemblies: agents for magnetic resonance imaging and neutron capture therapy. Biomater Sci. 2014 Jun 07;2(6):924-935. doi: 10.1039/c3bm60235d. Epub 2014 Feb 17. PMID: 32481823.
Copy Download .nbib Format: NLM
Share it on

Biomater Sci. 2014 Jun 07;2(6):924-935. doi: 10.1039/c3bm60235d. Epub 2014 Feb 17.

Gadolinium-DTPA amphiphile nanoassemblies: agents for magnetic resonance imaging and neutron capture therapy.

Biomaterials science

Minoo J Moghaddam, Liliana de Campo, Mioko Hirabayashi, Penny A Bean, Lynne J Waddington, Judith A Scoble, Gregory Coia, Calum J Drummond

Affiliations

  1. CSIRO Materials Science and Engineering, PO BOX 52, North Ryde, NSW 1670, Australia. [email protected].

PMID: 32481823 DOI: 10.1039/c3bm60235d

Abstract

Engineering biocompatible and physiologically stable nanoscaled therapeutics and imaging agents with the ability to target tumor tissue is a key challenge for the advancement of cancer therapeutics and diagnostic imaging. Here, we present chelating amphiphiles with the capacity to form nanoassembled colloidal particles containing high payloads of gadolinium (Gd) ions. We present the in situ synthesis and complexation of Gd with colloidal nanoassemblies (NAs) based on diethylenetriamine pentaacetic acid (DTPA) amphiphiles. This method allows for facile simultaneous incorporation of several metal ions for applications in multimodal imaging and therapeutics. The diverse internally nanostructured NAs made from sole precursor amphiphiles and their Gd-complexes were investigated by synchrotron small angle X-ray scattering (SAXS) and cryo-TEM. Depending on the molecular structure of the amphiphiles, the structures of NAs range from micelles to liposomes, to colloidal particles of inverse hexagonal (hexosomes) and inverse bicontinuous cubic phases (cubosomes), to multilayered nanospheres. The in vitro contrast activity of these NAs exhibited high relaxivity values as T

Publication Types