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Peyman A, Feizi A, Ganjalikhani-Hakemi M, et al. Outcome of Corneal Collagen Cross-Linking in Keratoconus: Introducing the Predictive Factors. J Curr Ophthalmol. 2020;32(1):19-25doi: 10.4103/JOCO.JOCO_48_20.
Peyman, A., Feizi, A., Ganjalikhani-Hakemi, M., Hosseini-Nasab, F., & Pourazizi, M. (2020). Outcome of Corneal Collagen Cross-Linking in Keratoconus: Introducing the Predictive Factors. Journal of current ophthalmology, 32(1), 19-25. https://doi.org/10.4103/JOCO.JOCO_48_20
Peyman, Alireza, et al. "Outcome of Corneal Collagen Cross-Linking in Keratoconus: Introducing the Predictive Factors." Journal of current ophthalmology vol. 32,1 (2020): 19-25. doi: https://doi.org/10.4103/JOCO.JOCO_48_20
Peyman A, Feizi A, Ganjalikhani-Hakemi M, Hosseini-Nasab F, Pourazizi M. Outcome of Corneal Collagen Cross-Linking in Keratoconus: Introducing the Predictive Factors. J Curr Ophthalmol. 2020 Mar 23;32(1):19-25. doi: 10.4103/JOCO.JOCO_48_20. eCollection 2020. PMID: 32510009; PMCID: PMC7265260.
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J Curr Ophthalmol. 2020 Mar 23;32(1):19-25. doi: 10.4103/JOCO.JOCO_48_20. eCollection 2020.

Outcome of Corneal Collagen Cross-Linking in Keratoconus: Introducing the Predictive Factors.

Journal of current ophthalmology

Alireza Peyman, Awat Feizi, Mazdak Ganjalikhani-Hakemi, Fahimeh Hosseini-Nasab, Mohsen Pourazizi

Affiliations

  1. Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
  2. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
  3. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 32510009 PMCID: PMC7265260 DOI: 10.4103/JOCO.JOCO_48_20

Abstract

PURPOSE: To evaluate the multiple pretreatment characteristics and topographic factors of keratoconus (KC) patients and their relationship to clinical outcomes of corneal collagen cross-linking (CXL).

METHODS: In this prospective study, 61 patients (106 eyes) with KC as candidates for CXL were included. Demographic data including age, sex, place of birth and residence, atopic constitution, family history, rubbing history, sleep apnea, and blood group were collected via a structured checklist. Complete ophthalmologic examination and tear collection to assess tear interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) level were performed. Topometric parameters were evaluated using a rotating Scheimpflug topography device. Changes in best corrected visual acuity (BCVA) and maximum keratometry (K-max) were considered the main predicted variables. Predictive variables were analyzed by univariate and multivariate regression.

RESULTS: The use of multivariate analysis changes in K-max was significantly associated with rubbing frequency (coefficient = 0.94,

CONCLUSION: Our results demonstrated that blood group, rubbing of eye, place of birth, corneal asphericity, pretreatment BCVA, CKI, KI, and CCT were statistically associated with the outcome of KC following CXL.

Copyright: © 2020 Journal of Current Ophthalmology.

Keywords: Cornea; Corneal topography; Cross-linking reagents; Interleukin 6; Keratoconus; Treatment outcome; Tumor necrosis factor alpha

Conflict of interest statement

There are no conflicts of interest.

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