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Kuri-Cervantes L, Pampena MB, Meng W, et al. Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection. bioRxiv. 2020;doi: 10.1101/2020.05.18.101717.
Kuri-Cervantes, L., Pampena, M. B., Meng, W., Rosenfeld, A. M., Ittner, C. A. G., Weisman, A. R., Agyekum, R., Mathew, D., Baxter, A. E., Vella, L., Kuthuru, O., Apostolidis, S., Bershaw, L., Dougherty, J., Greenplate, A. R., Pattekar, A., Kim, J., Han, N., Gouma, S., Weirick, M. E., Arevalo, C. P., Bolton, M. J., Goodwin, E. C., Anderson, E. M., Hensley, S. E., Jones, T. K., Mangalmurti, N. S., Luning Prak, E. T., Wherry, E. J., Meyer, N. J., & Betts, M. R. (2020). Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection. bioRxiv : the preprint server for biology, . https://doi.org/10.1101/2020.05.18.101717
Kuri-Cervantes, Leticia, et al. "Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection." bioRxiv : the preprint server for biology vol. (2020). doi: https://doi.org/10.1101/2020.05.18.101717
Kuri-Cervantes L, Pampena MB, Meng W, Rosenfeld AM, Ittner CAG, Weisman AR, Agyekum R, Mathew D, Baxter AE, Vella L, Kuthuru O, Apostolidis S, Bershaw L, Dougherty J, Greenplate AR, Pattekar A, Kim J, Han N, Gouma S, Weirick ME, Arevalo CP, Bolton MJ, Goodwin EC, Anderson EM, Hensley SE, Jones TK, Mangalmurti NS, Luning Prak ET, Wherry EJ, Meyer NJ, Betts MR. Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection. bioRxiv. 2020 May 18; doi: 10.1101/2020.05.18.101717. PMID: 32511394; PMCID: PMC7263541.
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bioRxiv. 2020 May 18; doi: 10.1101/2020.05.18.101717.

Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection.

bioRxiv : the preprint server for biology

Leticia Kuri-Cervantes, M Betina Pampena, Wenzhao Meng, Aaron M Rosenfeld, Caroline A G Ittner, Ariel R Weisman, Roseline Agyekum, Divij Mathew, Amy E Baxter, Laura Vella, Oliva Kuthuru, Sokratis Apostolidis, Luanne Bershaw, Jeannete Dougherty, Allison R Greenplate, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sigrid Gouma, Madison E Weirick, Claudia P Arevalo, Marcus J Bolton, Eileen C Goodwin, Elizabeth M Anderson, Scott E Hensley, Tiffanie K Jones, Nilam S Mangalmurti, Eline T Luning Prak, E John Wherry, Nuala J Meyer, Michael R Betts

PMID: 32511394 PMCID: PMC7263541 DOI: 10.1101/2020.05.18.101717

Abstract

Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.

ONE SENTENCE SUMMARY: Broad immune perturbations in severe COVID-19.

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