Display options
Cite
Hu JM, Qian MZ, Tanigawa H, et al. Focal Electrical Stimulation of Cortical Functional Networks. Cereb Cortex. 2020;30(10):5532-5543doi: 10.1093/cercor/bhaa136.
Hu, J. M., Qian, M. Z., Tanigawa, H., Song, X. M., & Roe, A. W. (2020). Focal Electrical Stimulation of Cortical Functional Networks. Cerebral cortex (New York, N.Y. : 1991), 30(10), 5532-5543. https://doi.org/10.1093/cercor/bhaa136
Hu, Jia Ming, et al. "Focal Electrical Stimulation of Cortical Functional Networks." Cerebral cortex (New York, N.Y. : 1991) vol. 30,10 (2020): 5532-5543. doi: https://doi.org/10.1093/cercor/bhaa136
Hu JM, Qian MZ, Tanigawa H, Song XM, Roe AW. Focal Electrical Stimulation of Cortical Functional Networks. Cereb Cortex. 2020 Sep 03;30(10):5532-5543. doi: 10.1093/cercor/bhaa136. PMID: 32483588.
Copy Download .nbib Format: NLM
Share it on

Cereb Cortex. 2020 Sep 03;30(10):5532-5543. doi: 10.1093/cercor/bhaa136.

Focal Electrical Stimulation of Cortical Functional Networks.

Cerebral cortex (New York, N.Y. : 1991)

Jia Ming Hu, Mei Zhen Qian, Hisashi Tanigawa, Xue Mei Song, Anna Wang Roe

Affiliations

  1. Department of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou 310029, China.
  2. Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, Hangzhou 310029, China.
  3. Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006 USA.

PMID: 32483588 DOI: 10.1093/cercor/bhaa136

Abstract

Traditional electrical stimulation of brain tissue typically affects relatively large volumes of tissue spanning multiple millimeters. This low spatial resolution stimulation results in nonspecific functional effects. In addition, a primary shortcoming of these designs was the failure to take advantage of inherent functional organization in the cerebral cortex. Here, we describe a new method to electrically stimulate the brain which achieves selective targeting of single feature-specific domains in visual cortex. We provide evidence that this paradigm achieves mesoscale, functional network-specificity, and intensity dependence in a way that mimics visual stimulation. Application of this approach to known feature domains (such as color, orientation, motion, and depth) in visual cortex may lead to important functional improvements in the specificity and sophistication of brain stimulation methods and has implications for visual cortical prosthetic design.

© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: brain–machine interface; electrical microstimulation; optical imaging; orientation map; visual cortex

Publication Types