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Severino P, D'Amato A, Netti L, et al. Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors. Eur J Prev Cardiol. 2020;2047487320926780doi: 10.1177/2047487320926780.
Severino, P., D'Amato, A., Netti, L., Pucci, M., Mariani, M. V., Cimino, S., Birtolo, L. I., Infusino, F., De Orchi, P., Palmirotta, R., Lovero, D., Silvestris, F., Caputo, V., Pizzuti, A., Miraldi, F., Maestrini, V., Mancone, M., & Fedele, F. (2020). Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors. European journal of preventive cardiology, 2047487320926780. https://doi.org/10.1177/2047487320926780
Severino, Paolo, et al. "Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors." European journal of preventive cardiology vol. (2020): 2047487320926780. doi: https://doi.org/10.1177/2047487320926780
Severino P, D'Amato A, Netti L, Pucci M, Mariani MV, Cimino S, Birtolo LI, Infusino F, De Orchi P, Palmirotta R, Lovero D, Silvestris F, Caputo V, Pizzuti A, Miraldi F, Maestrini V, Mancone M, Fedele F. Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors. Eur J Prev Cardiol. 2020 Jun 02;2047487320926780. doi: 10.1177/2047487320926780. Epub 2020 Jun 02. PMID: 32484043.
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Eur J Prev Cardiol. 2020 Jun 02;2047487320926780. doi: 10.1177/2047487320926780. Epub 2020 Jun 02.

Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors.

European journal of preventive cardiology

Paolo Severino, Andrea D'Amato, Lucrezia Netti, Mariateresa Pucci, Marco V Mariani, Sara Cimino, Lucia I Birtolo, Fabio Infusino, Paolo De Orchi, Raffaele Palmirotta, Domenica Lovero, Franco Silvestris, Viviana Caputo, Antonio Pizzuti, Fabio Miraldi, Viviana Maestrini, Massimo Mancone, Francesco Fedele

Affiliations

  1. Department of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Italy.
  2. Section of Clinical and Molecular Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Italy.
  3. Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I Hospital, Italy.

PMID: 32484043 DOI: 10.1177/2047487320926780

Abstract

AIMS: Ischaemic heart disease is classically associated with coronary artery disease. Recent evidences showed the correlation between coronary microvascular dysfunction and ischaemic heart disease, even independently of coronary artery disease. Ion channels represent the final effectors of blood flow regulation mechanisms and their genetic variants, in particular of Kir6.2 subunit of the ATP-sensitive potassium channel (K

METHODS: A total of 603 consecutive patients with indication for coronary angiography due to suspected myocardial ischaemia were enrolled. Patients were divided into three groups: coronary artery disease (G1), coronary microvascular dysfunction (G2) and normal coronary arteries (G3). Analysis of four single nucleotide polymorphisms (rs5215, rs5216, rs5218 and rs5219) of the

RESULTS: rs5215 A/A and G/A were significantly more represented in G1, while rs5215 G/G was significantly more represented in G3, rs5216 G/G and C/C were both more represented in G3, rs5218 C/C was more represented in G1 and rs5219 G/A was more represented in G1, while rs5219 G/G was significantly more represented in G2. At multivariate analysis, single nucleotide polymorphism rs5215_G/G seems to represent an ischaemic heart disease independent protective factor.

CONCLUSIONS: These results suggest the potential role of K

Keywords: ATP-sensitive potassium channel; Ion channels; coronary artery disease; coronary microvascular dysfunction; ischaemic heart disease; single nucleotide polymorphisms

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