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Cubero FJ, Mohamed MR, Woitok MM, et al. Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatol Commun. 2020;4(6):834-851doi: 10.1002/hep4.1495.
Cubero, F. J., Mohamed, M. R., Woitok, M. M., Zhao, G., Hatting, M., Nevzorova, Y. A., Chen, C., Haybaeck, J., de Bruin, A., Avila, M. A., Boekschoten, M. V., Davis, R. J., & Trautwein, C. (2020). Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatology communications, 4(6), 834-851. https://doi.org/10.1002/hep4.1495
Cubero, Francisco Javier, et al. "Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma." Hepatology communications vol. 4,6 (2020): 834-851. doi: https://doi.org/10.1002/hep4.1495
Cubero FJ, Mohamed MR, Woitok MM, Zhao G, Hatting M, Nevzorova YA, Chen C, Haybaeck J, de Bruin A, Avila MA, Boekschoten MV, Davis RJ, Trautwein C. Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatol Commun. 2020 Apr 16;4(6):834-851. doi: 10.1002/hep4.1495. eCollection 2020 Jun. PMID: 32490320; PMCID: PMC7262317.
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Hepatol Commun. 2020 Apr 16;4(6):834-851. doi: 10.1002/hep4.1495. eCollection 2020 Jun.

Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma.

Hepatology communications

Francisco Javier Cubero, Mohamed Ramadan Mohamed, Marius M Woitok, Gang Zhao, Maximilian Hatting, Yulia A Nevzorova, Chaobo Chen, Johannes Haybaeck, Alain de Bruin, Matias A Avila, Mark V Boekschoten, Roger J Davis, Christian Trautwein

Affiliations

  1. Department of Internal Medicine III University Hospital RWTH Aachen Aachen Germany.
  2. Department of Immunology, Ophthalmology, and ENT Complutense University School of Medicine Madrid Spain.
  3. 12 de Octubre Health Research Institute Madrid Spain.
  4. Department of Therapeutic Chemistry National Research Center Giza Egypt.
  5. Department of Genetics, Physiology, and Microbiology Faculty of Biology Complutense University Madrid Spain.
  6. Department of Pathology Otto-von-Guericke University Magdeburg Germany.
  7. Diagnostic and Research Center for Molecular BioMedicine Institute of Pathology Medical University of Graz Graz Austria.
  8. Department of Pathology, Neuropathology, and Molecular Pathology Medical University of Innsbruck Innsbruck Austria.
  9. Department of Pathobiology Faculty of Veterinary Medicine Dutch Molecular Pathology Center Utrecht University Utrecht the Netherlands.
  10. Department of Pediatrics University Medical Center Groningen University of Groningen Groningen the Netherlands.
  11. Instituto de Investigación Sanitaria de Navarra Pamplona Spain.
  12. Hepatology Program Center for Applied Medical Research University of Navarra Pamplona Spain.
  13. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos III Madrid Spain.
  14. Nutrition, Metabolism, and Genomics Group Division of Human Nutrition Wageningen University Wageningen the Netherlands.
  15. Howard Hughes Medical Institute University of Massachusetts Medical School Worcester MA.

PMID: 32490320 PMCID: PMC7262317 DOI: 10.1002/hep4.1495

Abstract

Targeted inhibition of the c-Jun N-terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)-related tumorigenesis. However, the cell-type-specific role and mechanisms triggered by JNK in liver parenchymal cells during CCA remain largely unknown. Here, we aimed to investigate the relevance of JNK1 and JNK2 function in hepatocytes in two different models of experimental carcinogenesis, the dethylnitrosamine (DEN) model and in nuclear factor kappa B essential modulator (NEMO)

© 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

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