Display options
Cite
Funai K, Kawase A, Mizuno K, et al. 8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter. Cancers (Basel). 2020;12(6)doi: 10.3390/cancers12061577.
Funai, K., Kawase, A., Mizuno, K., Koyama, S., & Shiiya, N. (2020). 8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter. Cancers, 12(6), . https://doi.org/10.3390/cancers12061577
Funai, Kazuhito, et al. "8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter." Cancers vol. 12,6 (2020). doi: https://doi.org/10.3390/cancers12061577
Funai K, Kawase A, Mizuno K, Koyama S, Shiiya N. 8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter. Cancers (Basel). 2020 Jun 15;12(6). doi: 10.3390/cancers12061577. PMID: 32549242; PMCID: PMC7353035.
Copy Download .nbib Format: NLM
Share it on

Cancers (Basel). 2020 Jun 15;12(6). doi: 10.3390/cancers12061577.

8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter.

Cancers

Kazuhito Funai, Akikazu Kawase, Kiyomichi Mizuno, Sin Koyama, Norihiko Shiiya

Affiliations

  1. First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

PMID: 32549242 PMCID: PMC7353035 DOI: 10.3390/cancers12061577

Abstract

The biggest change in the 8th edition of the tumor, lymph node, and metastasis (TNM) classification is the recommendation of the solid component diameter and invasive size for determining the clinical and pathological T-factor, respectively. Here, we validated new proposals for the Lung Cancer TNM classification's revision and compared clinical and pathological T-stages. We retrospectively analyzed 177 cases of non-small cell lung cancers without lymph node metastasis, and involving complete resection, that occurred in our department between January 2017 and March 2019. We reviewed the overall tumor diameter, solid component diameter, and clinical T-factor on computed tomography (CT), and the pathological tumor diameter, pathological invasion diameter, pathological T-factor, and prognosis. The difference between the pathological invasive size and solid size on CT was within 5 mm in 99 cases (56%). At a two-year recurrence-free survival rate, the clinical T-stage demonstrated a better prognostic outcome than the pathological T-stage. Despite including the benign findings, the solid component diameter was better correlated with prognosis than the invasive size. Therefore, in cases of discrepancies of clinically and pathologically detected tumor size, the solid CT size should also be used for the pathological T classification.

Keywords: T descriptor; TNM classification; lung cancer prognosis; pathological invasive size; solid part

References

  1. J Thorac Cardiovasc Surg. 2012 Mar;143(3):607-12 - PubMed
  2. J Clin Oncol. 2005 Aug 1;23(22):4999-5006 - PubMed
  3. J Thorac Oncol. 2017 Sep;12(9):1403-1412 - PubMed
  4. Pathol Int. 2005 Jan;55(1):8-13 - PubMed
  5. J Thorac Oncol. 2019 Feb;14(2):265-275 - PubMed
  6. Clin Lung Cancer. 2018 May;19(3):e303-e312 - PubMed
  7. Histopathology. 2019 Nov;75(5):649-659 - PubMed
  8. Eur Radiol. 2015 Feb;25(2):558-67 - PubMed
  9. Hum Pathol. 2016 May;51:41-50 - PubMed
  10. Turk Patoloji Derg. 2014;30(2):105-10 - PubMed
  11. J Thorac Oncol. 2018 Apr;13(4):533-542 - PubMed
  12. J Clin Oncol. 2008 Jul 20;26(21):3552-9 - PubMed
  13. J Thorac Oncol. 2016 Jan;11(1):39-51 - PubMed
  14. J Thorac Oncol. 2015 Sep;10(9):1240-1242 - PubMed
  15. Am J Clin Pathol. 2018 Oct 24;150(6):499-506 - PubMed
  16. J Thorac Oncol. 2015 Jul;10(7):990-1003 - PubMed
  17. J Thorac Dis. 2018 Jan;10(1):162-167 - PubMed
  18. Eur J Cardiothorac Surg. 2018 Dec 1;54(6):1028-1036 - PubMed
  19. J Thorac Oncol. 2011 Jul;6(7):1229-35 - PubMed
  20. Ann Thorac Surg. 2000 Mar;69(3):893-7 - PubMed
  21. J Thorac Oncol. 2016 Aug;11(8):1204-1223 - PubMed

Publication Types