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Mohammadi Kanesbi M, Jarahi L, Keramati MR. Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: . Int J Hematol Oncol Stem Cell Res. 2020;14(2):130-139
Mohammadi Kanesbi, M., Jarahi, L., & Keramati, M. R. (2020). Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: . International journal of hematology-oncology and stem cell research, 14(2), 130-139.
Mohammadi Kanesbi, Mehdi, et al. "Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: ." International journal of hematology-oncology and stem cell research vol. 14,2 (2020): 130-139.
Mohammadi Kanesbi M, Jarahi L, Keramati MR. Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: . Int J Hematol Oncol Stem Cell Res. 2020 Apr 01;14(2):130-139. PMID: 32461798; PMCID: PMC7231793.
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Int J Hematol Oncol Stem Cell Res. 2020 Apr 01;14(2):130-139.

Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: .

International journal of hematology-oncology and stem cell research

Mehdi Mohammadi Kanesbi, Lida Jarahi, Mohammad Reza Keramati

Affiliations

  1. Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  2. Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 32461798 PMCID: PMC7231793

Abstract

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). APL is famed with some special blood coagulation disorders such as disseminated intravascular coagulation (DIC). The therapeutic methods of APL contain All Trans Retinoic Acid (ATRA), arsenic trioxide (ATO) or/and chemotherapy. Many studies have been done on APL blood disorders and its treatment. These studies have shown different results. In this systematic article, we tried to review the effect of ATO therapy with or without ATRA and chemotherapy on DIC parameters (D-dimer, Prothrombin Time, Activated Partial Thrombin Time, Platelet count) in APL patients. The result of included studies demonstrated that although ATO can reduce the number of malignant cells in the bone marrow and peripheral blood, it does not have enough potential to attenuate the danger of high score DIC that is usual in APL patients and should be better to be used with other therapeutic methods.

Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences.

Keywords: Acute promyelocytic leukemia; All-trans retinoic acid; Arsenic trioxide; Chemotherapy; Disseminated intravascular coagulation

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