Display options
Cite
Jani V, Shivaram P, Porter TR, et al. Ultrasound Theranostics in Adult and Pediatric Cardiovascular Research. Cardiovasc Drugs Ther. 2021;35(1):185-190doi: 10.1007/s10557-020-07016-7.
Jani, V., Shivaram, P., Porter, T. R., & Kutty, S. (2021). Ultrasound Theranostics in Adult and Pediatric Cardiovascular Research. Cardiovascular drugs and therapy, 35(1), 185-190. https://doi.org/10.1007/s10557-020-07016-7
Jani, Vivek, et al. "Ultrasound Theranostics in Adult and Pediatric Cardiovascular Research." Cardiovascular drugs and therapy vol. 35,1 (2021): 185-190. doi: https://doi.org/10.1007/s10557-020-07016-7
Jani V, Shivaram P, Porter TR, Kutty S. Ultrasound Theranostics in Adult and Pediatric Cardiovascular Research. Cardiovasc Drugs Ther. 2021 Feb;35(1):185-190. doi: 10.1007/s10557-020-07016-7. PMID: 32495071.
Copy Download .nbib Format: NLM
Share it on

Cardiovasc Drugs Ther. 2021 Feb;35(1):185-190. doi: 10.1007/s10557-020-07016-7.

Ultrasound Theranostics in Adult and Pediatric Cardiovascular Research.

Cardiovascular drugs and therapy

Vivek Jani, Pushpa Shivaram, Thomas R Porter, Shelby Kutty

Affiliations

  1. The Helen B. Taussig Heart Center, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, M2315, 1800 Orleans St, Baltimore, MD, 21287, USA.
  2. Division of Cardiology, Department of Pediatrics, Augusta University, Augusta, GA, USA.
  3. Division of Cardiology, University of Nebraska Medical Center College of Medicine, Omaha, NE, USA.
  4. The Helen B. Taussig Heart Center, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, M2315, 1800 Orleans St, Baltimore, MD, 21287, USA. [email protected].

PMID: 32495071 DOI: 10.1007/s10557-020-07016-7

Abstract

Theranostics, the practice of systematically integrating diagnostics with treatment, has evolved as a field of medicine. In the context of ultrasound based theranostics, both traditional microbubbles and inorganic nanoparticles have emerged as technologies of clinical interest. Ultrasound induced microbubble cavitation has demonstrated efficacy in a variety of applications, including thrombolysis, tumor ablation, targeted microvascular flow enhancement, and targeted drug and gene delivery. This commentary summarizes the mechanisms and applications of ultrasound-based theranostics in cardiovascular medicine, including its impact in pediatric cardiology. It also provides an overview of ongoing clinical trials for theranostics in cardiovascular medicine.

Keywords: Cavitation; Pediatric cardiology; Theranostics; Ultrasound

References

  1. Senior R, Becher H, Monaghan M, Agati L, Zamorano J, Vanoverschelde JL, et al. Clinical practice of contrast echocardiography: recommendation by the European Association of Cardiovascular Imaging (EACVI) 2017. Eur Hear Journal-Cardiovascular Imaging. Oxford University Press. 2017;18:1205–1205af. - PubMed
  2. Porter TR, Mulvagh SL, Abdelmoneim SS, Becher H, Belcik JT, Bierig M, et al. Clinical applications of ultrasonic enhancing agents in echocardiography: 2018 American Society of Echocardiography guidelines update. J Am Soc Echocardiogr. Elsevier. 2018;31:241–74. - PubMed
  3. Yani L, Davidson BP, Qi Y, Todd B, Aris X, Yoichi I, et al. Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging [Internet]. American Heart Association. 2013;6:74–82. - PubMed
  4. Mathias W, Tsutsui JM, Tavares BG, Fava AM, Aguiar MOD, Borges BC, et al. Sonothrombolysis in ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2019;73:2832–42. - PubMed
  5. Vignon F, Shi WT, Powers JE, Everbach EC, Liu J, Gao S, et al. Microbubble cavitation imaging. IEEE Trans Ultrason Ferroelectr Freq Control. IEEE. 2013;60:661–70. - PubMed
  6. Culp WC, Flores R, Brown AT, Lowery JD, Roberson PK, Hennings LJ, et al. Successful microbubble sonothrombolysis without tissue-type plasminogen activator in a rabbit model of acute ischemic stroke. Stroke [Internet]. American Heart Association. 2011;42:2280–5. - PubMed
  7. Molina CA, Ribo M, Rubiera M, Montaner J, Santamarina E, Delgado-Mederos R, et al. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke. Am Heart Assoc. 2006;37:425–9. - PubMed
  8. Porter TR, Xie F, Lof J, Powers J, Vignon F, Shi W, et al. The thrombolytic effect of diagnostic ultrasound-induced microbubble cavitation in acute carotid thromboembolism. Invest Radiol. NIH Public Access. 2017;52:477–81. - PubMed
  9. Mathias W, Tsutsui JM, Tavares BG, Xie F, Aguiar MOD, Garcia DR, et al. Diagnostic ultrasound impulses improve microvascular flow in patients with STEMI receiving intravenous microbubbles. J Am Coll Cardiol. 2016;67:2506–15. - PubMed
  10. Aguiar MOD, Tavares BG, Tsutsui JM, Fava AM, Borges BC, Oliveira MT Jr, et al. Sonothrombolysis improves myocardial dynamics and microvascular obstruction preventing left ventricular remodeling in patients with ST elevation myocardial infarction. Circ Cardiovasc Imaging. Am Heart Assoc. 2020;13:e009536. - PubMed
  11. Belcik JT, Mott BH, Xie A, Zhao Y, Kim S, Lindner NJ, et al. Augmentation of limb perfusion and reversal of tissue ischemia produced by ultrasound-mediated microbubble cavitation. Circ Cardiovasc Imaging. Am Heart Assoc. 2015;8:e002979. - PubMed
  12. Cooper B, Bachoo P. Extracorporeal shock wave therapy for the healing and management of venous leg ulcers. Cochrane Database Syst Rev. Wiley. 2018;6:CD011842. - PubMed
  13. Atar S, Siegel RJ, Akel R, Ye Y, Lin Y, Modi SA, et al. Ultrasound at 27 kHz increases tissue expression and activity of nitric oxide synthases in acute limb ischemia in rabbits. Ultrasound Med Biol. Elsevier. 2007;33:1483–8. - PubMed
  14. Messa CA IV, Chatman BC, Rhemtulla IA, Broach RB, Mauch JT, D’Angelantonio AM III, et al. Ultrasonic debridement management of lower extremity wounds: retrospective analysis of clinical outcomes and cost. J Wound Care. MA Healthcare London. 2019;28:S30–40. - PubMed
  15. Kutty S, Wu J, Hammel JM, Xie F, Gao S, Drvol LK, et al. Microbubble mediated thrombus dissolution with diagnostic ultrasound for the treatment of chronic venous thrombi. PLoS One. Public Library of Science. 2012;7:e51453. - PubMed
  16. Kutty S, Liu N, Zhou J, Xiao Y, Wu J, Danford DA, et al. Ultrasound-induced microbubble cavitation for the treatment of catheterization-induced vasospasm. JACC Basic to Transl Sci. 2017;2:748–56. - PubMed
  17. Mathias W, Arrieta SR, Tavares GMP, Sbano JCN, Tsutsui JM, Kutty S, et al. Successful recanalization of thrombotic occlusion in pulmonary artery stent using sonothrombolysis. CASE. Elsevier. 2019;3:14–7. - PubMed
  18. Chen S, Ding J, Bekeredjian R, Yang B, Shohet RV, Johnston SA, et al. Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci. National Acad Sciences. 2006;103:8469–74. - PubMed
  19. Mofid A, Newman NS, Lee PJH, Abbasi C, Matkar PN, Rudenko D, et al. Cardiac overexpression of S100A6 attenuates cardiomyocyte apoptosis and reduces infarct size after myocardial ischemia-reperfusion. J Am Heart Assoc. Am Heart Assoc. 2017;6:e004738. - PubMed
  20. Cao WJ, Rosenblat JD, Roth NC, Kuliszewski MA, Matkar PN, Rudenko D, et al. Therapeutic angiogenesis by ultrasound-mediated microRNA-126-3p delivery. Arterioscler Thromb Vasc Biol. Am Heart Assoc. 2015;35:2401–11. - PubMed

Publication Types