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Nielsen MKF, Christensen JF, Frandsen TL, et al. Effects of a physical activity program from diagnosis on cardiorespiratory fitness in children with cancer: a national non-randomized controlled trial. BMC Med. 2020;18(1):175doi: 10.1186/s12916-020-01634-6.
Nielsen, M. K. F., Christensen, J. F., Frandsen, T. L., Thorsteinsson, T., Andersen, L. B., Christensen, K. B., Wehner, P. S., Hasle, H., Adamsen, L. �. �., Schmiegelow, K., & Larsen, H. B. (2020). Effects of a physical activity program from diagnosis on cardiorespiratory fitness in children with cancer: a national non-randomized controlled trial. BMC medicine, 18(1), 175. https://doi.org/10.1186/s12916-020-01634-6
Nielsen, Martin Kaj Fridh, et al. "Effects of a physical activity program from diagnosis on cardiorespiratory fitness in children with cancer: a national non-randomized controlled trial." BMC medicine vol. 18,1 (2020): 175. doi: https://doi.org/10.1186/s12916-020-01634-6
Nielsen MKF, Christensen JF, Frandsen TL, Thorsteinsson T, Andersen LB, Christensen KB, Wehner PS, Hasle H, Adamsen LØ, Schmiegelow K, Larsen HB. Effects of a physical activity program from diagnosis on cardiorespiratory fitness in children with cancer: a national non-randomized controlled trial. BMC Med. 2020 Jul 06;18(1):175. doi: 10.1186/s12916-020-01634-6. PMID: 32624004; PMCID: PMC7336676.
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BMC Med. 2020 Jul 06;18(1):175. doi: 10.1186/s12916-020-01634-6.

Effects of a physical activity program from diagnosis on cardiorespiratory fitness in children with cancer: a national non-randomized controlled trial.

BMC medicine

Martin Kaj Fridh Nielsen, Jesper Frank Christensen, Thomas Leth Frandsen, Troels Thorsteinsson, Lars Bo Andersen, Karl Bang Christensen, Peder Skov Wehner, Henrik Hasle, Lis Ørgaard Adamsen, Kjeld Schmiegelow, Hanne Bækgaard Larsen

Affiliations

  1. Department of Pediatrics and Adolescent Medicine, The Juliane Marie Center, University Hospital of Copenhagen (Rigshospitalet), Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
  2. The University of Copenhagen, Faculty of Health Science, Institute for Clinical Medicine, Copenhagen, Denmark.
  3. Center for Inflammation and Metabolism/Center for Physical Activity (CIM/CFAS), University Hospital (Rigshospitalet), Copenhagen, Denmark.
  4. Department of Sports Medicine, Norwegian School for Sports Sciences, Oslo, Norway.
  5. Faculty of Education, Arts and Sports, Department of Sport, Food and Natural Sciences,Western Norway University of Applied Sciences, Post box 133, 6851, Sognal, Norway.
  6. Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
  7. Department of Pediatric Hematology and Oncology, H.C. Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
  8. Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
  9. Faculty of Health Science, Department of Public Health, Institute for Clinical Medicine, The University of Copenhagen, Copenhagen, Denmark.
  10. The University Hospitals Centre for Health Research (UCSF), University Hospital (Rigshospitalet), Copenhagen, Denmark.
  11. Department of Pediatrics and Adolescent Medicine, The Juliane Marie Center, University Hospital of Copenhagen (Rigshospitalet), Blegdamsvej 9, DK-2100, Copenhagen, Denmark. [email protected].

PMID: 32624004 PMCID: PMC7336676 DOI: 10.1186/s12916-020-01634-6

Abstract

BACKGROUND: Children with cancer experience impaired cardiorespiratory fitness and physical function during and after treatment restricting their possibilities to engage in social activities including sport, leisure activities, and school. The objectives were to determine the effects of classmate-supported, controlled, supervised, in-hospital, physical activity program to preserve cardiorespiratory fitness and physical function from time of diagnosis in children with cancer.

METHODS: National non-randomized controlled trial including schoolchildren aged 6-18 years at diagnosis treated with chemo-/radiotherapy. We included 120 of 128 eligible patients (94%) in the intervention group (62.5% boys, 11.2 ± 3.1 years) from East Denmark and 58 patients in the control group (57% boys, 11.0 ± 3.2 years) from West Denmark. Eight children from the control group withdrew from participation. The groups were comparable in anthropometrics and cancer diagnoses (p > 0.05). The intervention consisted of (i) supervised in-hospital physical activity from diagnosis and throughout intensive treatment, (ii) 90-min general educational session on cancer and therapy in the child's school class, and (iii) selection of two classmates as ambassadors who took turns to support the child's physical training during the daytime. The primary outcome was cardiorespiratory fitness (VO

RESULTS: Ambassadors were identified for all, and 2542 individual and 621 group training sessions were held. VO

CONCLUSIONS: Peer-supported, supervised, in-hospital, physical activity is safe and feasible in children with cancer during treatment. Further, the results suggest that the intervention might mitigate impairments in cardiorespiratory fitness during treatment in children with cancer.

TRIAL REGISTRATION: The study was prospectively registered on the 11 January 2013. Clinicaltrial.gov NCT01772849 and NCT01772862 .

Keywords: Cardiorespiratory fitness; Childhood cancer; Exercise

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