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Yamamoto Y, Yamamoto Y, Saita T, et al. Immunohistochemical Pharmacokinetics of the Anti-diabetes Drug Alogliptin in Rat Kidney and Liver. Acta Histochem Cytochem. 2020;53(3):55-60doi: 10.1267/ahc.19036.
Yamamoto, Y., Yamamoto, Y., Saita, T., Hira, D., Chijiwa, T., & Shin, M. (2020). Immunohistochemical Pharmacokinetics of the Anti-diabetes Drug Alogliptin in Rat Kidney and Liver. Acta histochemica et cytochemica, 53(3), 55-60. https://doi.org/10.1267/ahc.19036
Yamamoto, Yutaro, et al. "Immunohistochemical Pharmacokinetics of the Anti-diabetes Drug Alogliptin in Rat Kidney and Liver." Acta histochemica et cytochemica vol. 53,3 (2020): 55-60. doi: https://doi.org/10.1267/ahc.19036
Yamamoto Y, Yamamoto Y, Saita T, Hira D, Chijiwa T, Shin M. Immunohistochemical Pharmacokinetics of the Anti-diabetes Drug Alogliptin in Rat Kidney and Liver. Acta Histochem Cytochem. 2020 Jun 26;53(3):55-60. doi: 10.1267/ahc.19036. Epub 2020 May 29. PMID: 32624630; PMCID: PMC7322161.
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Acta Histochem Cytochem. 2020 Jun 26;53(3):55-60. doi: 10.1267/ahc.19036. Epub 2020 May 29.

Immunohistochemical Pharmacokinetics of the Anti-diabetes Drug Alogliptin in Rat Kidney and Liver.

Acta histochemica et cytochemica

Yutaro Yamamoto, Yuta Yamamoto, Tetsuya Saita, Daisuke Hira, Takahito Chijiwa, Masashi Shin

Affiliations

  1. Department of Applied Life Science, Faculty of Biotechnology and Life Science, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.

PMID: 32624630 PMCID: PMC7322161 DOI: 10.1267/ahc.19036

Abstract

Alogliptin is one of a new class of therapeutic agents for type 2 diabetes called dipeptidyl peptidase-4 inhibitors. Here, we used immunohistochemistry to investigate the pharmacokinetics of alogliptin at the cell and tissue levels in the rat kidney and liver. One hour after alogliptin administration, the most noticeable immunoreactivity in the kidney was a moderate-to-strong staining in proximal tubule S3 segment epithelial cells. On the other hand, immunostaining was found only in the microvilli of S1 and S2 segment cells. Immunoreactivity was also observed in the glomerulus and distal tubules. Positive cells and almost negative cells coexisted in the collecting ducts. Twenty-four hours after administration, moderate immunostaining remained in the S3 segment but staining in other regions had almost disappeared. In the liver 1 hr after administration, hepatocyte staining differed in the hepatic lobule, with zone III being stronger than zone I. Immunostaining had almost disappeared 24 hr after administration. These findings suggest that alogliptin reabsorption at the kidney and uptake at the hepatocyte vary from region to region and that one or more types of transporter are involved in these processes. In addition, long-term alogliptin use may cause the drug to accumulate in S3 segment, leading to adverse events.

2020 The Japan Society of Histochemistry and Cytochemistry.

Keywords: alogliptin; immunohistochemistry; kidney; liver; pharmacokinetics

Conflict of interest statement

VThe authors declare no conflicts of interest.

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