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Chen YC, Yang SL, Yang H, et al. Clinical characteristics of echovirus 11 and coxsackievirus B5 infections in Taiwanese children requiring hospitalization. J Microbiol Immunol Infect. 2020;54(4):581-587doi: 10.1016/j.jmii.2020.06.008.
Chen, Y. C., Yang, S. L., Yang, H., Lin, T. Y., Hsieh, Y. C., Huang, K. A., Kuo, C. Y., Chiu, C. H., Huang, Y. C., Chu, S. M., & Chen, C. J. (2021). Clinical characteristics of echovirus 11 and coxsackievirus B5 infections in Taiwanese children requiring hospitalization. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 54(4), 581-587. https://doi.org/10.1016/j.jmii.2020.06.008
Chen, Yi-Ching, et al. "Clinical characteristics of echovirus 11 and coxsackievirus B5 infections in Taiwanese children requiring hospitalization." Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi vol. 54,4 (2021): 581-587. doi: https://doi.org/10.1016/j.jmii.2020.06.008
Chen YC, Yang SL, Yang H, Lin TY, Hsieh YC, Huang KA, Kuo CY, Chiu CH, Huang YC, Chu SM, Chen CJ. Clinical characteristics of echovirus 11 and coxsackievirus B5 infections in Taiwanese children requiring hospitalization. J Microbiol Immunol Infect. 2021 Aug;54(4):581-587. doi: 10.1016/j.jmii.2020.06.008. Epub 2020 Jul 04. PMID: 32653431.
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J Microbiol Immunol Infect. 2021 Aug;54(4):581-587. doi: 10.1016/j.jmii.2020.06.008. Epub 2020 Jul 04.

Clinical characteristics of echovirus 11 and coxsackievirus B5 infections in Taiwanese children requiring hospitalization.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

Yi-Ching Chen, Shu-Li Yang, Hsuan Yang, Tzou-Yien Lin, Yu-Chia Hsieh, Kuan-Ying Arthur Huang, Chen-Yen Kuo, Cheng-Hsun Chiu, Yhu-Chering Huang, Shih-Ming Chu, Chih-Jung Chen

Affiliations

  1. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, Taiwan.
  2. Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan.
  3. Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan.
  4. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, Taiwan. Electronic address: [email protected].

PMID: 32653431 DOI: 10.1016/j.jmii.2020.06.008

Abstract

BACKGROUND: Severe illness can occur in young children infected with certain types of enteroviruses including echovirus 11 (Echo11) and coxsackievirus B5 (CoxB5). The manifestations and outcomes of Echo11 and CoxB5 diseases across all ages of children remained not comprehensively characterized in Taiwan.

METHODS: Culture-confirmed Echo11 (60 patients) or CoxB5 (65 patients) infections were identified in a hospital from 2010 to 2018. The demographics, clinical presentations, laboratory data and outcomes were abstracted and compared between the two viruses infections.

RESULTS: Echo11 and CoxB5 was respectively identified in 7 (77.8%) and 2 (22.2%) of 9 calendar years. The median age of all patients was 15 months (range, 1 day-14.5 years). For infants ≤3 months old, Echo11 (23 cases) was associated with higher incidence of aseptic meningitis (35% versus 0%, P = 0.003), and a lower rate of upper respiratory tract infections (URI) (22% versus 65%, P = 0.004) compared to CoxB5 (20 cases) infections. For patients >3 months old, URI was the cardinal diagnosis (60%) for both viruses. Aseptic meningitis was also more commonly identified in elder children with Echo11 infections (27% versus 11%), though with marginal significance (P = 0.07). Acute liver failure was identified in four young infants with Echo11 infections including one neonate dying of severe sepsis and myocarditis. All patients with CoxB5 infections recovered uneventfully.

CONCLUSION: Aseptic meningitis, sepsis-like illness and acute liver failure were more commonly identified in children with Echo11 than those with CoxB5 infections, suggesting greater neurological tropism and virulence toward Echo11.

Copyright © 2020. Published by Elsevier B.V.

Keywords: Clinical features; Coxsackievirus B5; Echovirus 11; Neonates; Taiwan

Conflict of interest statement

Declaration of Competing Interest All authors declare no conflict of interest.

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