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Contaldo M, Boccellino M, Zannini G, et al. Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View. J Oncol. 2020;2020:9587971doi: 10.1155/2020/9587971.
Contaldo, M., Boccellino, M., Zannini, G., Romano, A., Sciarra, A., Sacco, A., Settembre, G., Coppola, M., Di Carlo, A., D'Angelo, L., Inchingolo, F., Feola, A., & Di Domenico, M. (2020). Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View. Journal of oncology, 20209587971. https://doi.org/10.1155/2020/9587971
Contaldo, Maria, et al. "Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View." Journal of oncology vol. 2020 (2020): 9587971. doi: https://doi.org/10.1155/2020/9587971
Contaldo M, Boccellino M, Zannini G, Romano A, Sciarra A, Sacco A, Settembre G, Coppola M, Di Carlo A, D'Angelo L, Inchingolo F, Feola A, Di Domenico M. Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View. J Oncol. 2020 Jun 27;2020:9587971. doi: 10.1155/2020/9587971. eCollection 2020. PMID: 32684934; PMCID: PMC7336237.
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J Oncol. 2020 Jun 27;2020:9587971. doi: 10.1155/2020/9587971. eCollection 2020.

Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View.

Journal of oncology

Maria Contaldo, Mariarosaria Boccellino, Giuseppa Zannini, Antonio Romano, Antonella Sciarra, Alessandra Sacco, Giuliana Settembre, Mario Coppola, Angelina Di Carlo, Luigi D'Angelo, Francesco Inchingolo, Antonia Feola, Marina Di Domenico

Affiliations

  1. Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", Naples, NA, Italy.
  2. Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, NA, Italy.
  3. Department of Biology, University of Naples "Federico II", Naples, NA, Italy.
  4. Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, NA, Italy.
  5. Cell Biology and Biotherapy Unit, Tumor National Istitute "Fondazione G. Pascale"-IRCCS, Naples, NA, Italy.
  6. Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy.
  7. Department of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, Italy.
  8. Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA.

PMID: 32684934 PMCID: PMC7336237 DOI: 10.1155/2020/9587971

Abstract

Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via genetic and epigenetic factors.

Copyright © 2020 Maria Contaldo et al.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

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