J Immunoassay Immunochem. 2020 Sep 02;41(5):817-832. doi: 10.1080/15321819.2020.1779740. Epub 2020 Jun 24.

Classifying multiple lung cancers using morphological features: a meta-analysis.

Journal of immunoassay & immunochemistry

Mona Mlika, Majdi Zorgati, Faouzi El Mezni

PMID: 32579047 DOI: 10.1080/15321819.2020.1779740

Abstract

Multiple lung cancers may be intrapulmonary metastases or multiple primaries. Management and prognosis of both entities are different and make the pathologist's role challenging. In fact, distinguishing both entities may be difficult especially when the tumors present the same microscopic subtype. The microscopic diagnoses of these tumors have been improved based on the 2015 WHO classification. The aim of the authors was to assess the diagnostic value of morphologic features in comparison to the gold standard test represented by molecular testing in the distinction between intrapulmonary metastases and multiple lung primaries. To retrieve all eligible articles, PubMed and Embase databases and Cochrane Library were comprehensively searched from 1999 to 2020 with limitation to French andEnglish language. The Meta-Disc software 5.1.32 was used to conduct this meta-analysis. The pSEN, pSPE, NLR, PLR, and DOR with the 95% confidence intervals were calculated. The area under the SROC was calculated based on the SEN and SPE of each study. Q test and I

Keywords: Multiple lung cancers; molecular tests; morphologic criteria; next-generation sequencing

MeSH terms

• Humans
• Lung Neoplasms / diagnosis
• Lung Neoplasms / genetics

Publication Types

• Journal Article
• Meta-Analysis
• Review