Display options
Cite
Li Z, Wang D, Cheng Y, et al. Association between neonatal birthweight and risk of maternal glucose intolerance after gestational diabetes mellitus. J Diabetes Investig. 2020;12(3):425-433doi: 10.1111/jdi.13349.
Li, Z., Wang, D., Cheng, Y., Chen, P., Ding, W., & Wang, Z. (2021). Association between neonatal birthweight and risk of maternal glucose intolerance after gestational diabetes mellitus. Journal of diabetes investigation, 12(3), 425-433. https://doi.org/10.1111/jdi.13349
Li, Zhuyu, et al. "Association between neonatal birthweight and risk of maternal glucose intolerance after gestational diabetes mellitus." Journal of diabetes investigation vol. 12,3 (2021): 425-433. doi: https://doi.org/10.1111/jdi.13349
Li Z, Wang D, Cheng Y, Chen P, Ding W, Wang Z. Association between neonatal birthweight and risk of maternal glucose intolerance after gestational diabetes mellitus. J Diabetes Investig. 2021 Mar;12(3):425-433. doi: 10.1111/jdi.13349. Epub 2020 Aug 11. PMID: 32628808; PMCID: PMC7926240.
Copy Download .nbib Format: NLM
Share it on

J Diabetes Investig. 2021 Mar;12(3):425-433. doi: 10.1111/jdi.13349. Epub 2020 Aug 11.

Association between neonatal birthweight and risk of maternal glucose intolerance after gestational diabetes mellitus.

Journal of diabetes investigation

Zhuyu Li, Dongyu Wang, Yunjiu Cheng, Peisong Chen, Wenjing Ding, Zilian Wang

Affiliations

  1. Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  2. Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  3. Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  4. Department of Obstetrics and Gynaecology, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

PMID: 32628808 PMCID: PMC7926240 DOI: 10.1111/jdi.13349

Abstract

AIMS/INTRODUCTION: To evaluate whether the neonatal birthweight (NBW) is associated with early postpartum glucose intolerance in women with gestational diabetes mellitus.

MATERIALS AND METHODS: A total of 1,113 women diagnosed with gestational diabetes mellitus who completed an oral glucose tolerance test at 6-9 weeks postpartum between 1 April 2014 and 8 January 2020 were included in this observational prospective cohort study. They were grouped by neonatal birthweight quartiles, and the odds ratios of postpartum glucose intolerance for different levels of neonatal birthweight were assessed.

RESULTS: A lower NBW quartile was associated with an increased maternal risk of postpartum glucose intolerance after gestational diabetes mellitus. The adjusted odds ratios for maternal glucose intolerance were 1.69 (95% confidence interval 1.13-2.51) in the lowest NBW quartile (NBW 1,980-2,930 g) when compared with the highest NBW quartile (NBW 3,410-4,610 g). The association between lower NBW and maternal glucose intolerance was significantly stronger in women who delivered a girl. Additionally, NBW ≥3,100 g appears to be associated with a lower risk of maternal glucose intolerance postpartum.

CONCLUSIONS: Our findings suggest that low NBW is a previously unrecognized risk factor for maternal glucose intolerance after gestational diabetes in early postpartum in South China.

© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

Keywords: Birthweight; Gestational diabetes mellitus; Glucose intolerance

References

  1. Endocrine. 2017 Mar;55(3):809-821 - PubMed
  2. Diabetes Care. 2006 Jun;29(6):1345-50 - PubMed
  3. Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E25-30 - PubMed
  4. Diabetes Res Clin Pract. 2007 Dec;78(3):305-12 - PubMed
  5. J Clin Invest. 2005 Mar;115(3):485-91 - PubMed
  6. Diabetes Care. 2001 Aug;24(8):1317-8 - PubMed
  7. J Diabetes Investig. 2021 Mar;12(3):425-433 - PubMed
  8. J Clin Endocrinol Metab. 2015 Jul;100(7):2574-80 - PubMed
  9. Diabetes Care. 2020 Jan;43(Suppl 1):S183-S192 - PubMed
  10. Clin Diabetes. 2019 Jan;37(1):11-34 - PubMed
  11. Diabetes. 1998 Aug;47(8):1302-10 - PubMed
  12. J Clin Endocrinol Metab. 2012 May;97(5):1720-8 - PubMed
  13. Acta Endocrinol (Copenh). 1954 Aug;16(4):330-42 - PubMed
  14. JAMA. 2018 Sep 11;320(10):1005-1016 - PubMed
  15. Diabetologia. 2010 Mar;53(3):452-7 - PubMed
  16. Diabetes. 2002 Jul;51(7):2214-9 - PubMed
  17. N Engl J Med. 2008 May 8;358(19):1991-2002 - PubMed
  18. Diabetes Care. 2013 Jan;36 Suppl 1:S11-66 - PubMed
  19. Diabet Med. 2016 Nov;33(11):1599-1601 - PubMed
  20. Diabetes Care. 1993 Dec;16(12):1598-605 - PubMed
  21. Diabetes Care. 2016 Jun;39(6):1052-5 - PubMed
  22. Singapore Med J. 2012 Dec;53(12):814-20 - PubMed
  23. Chin Med J (Engl). 2008 Apr 20;121(8):696-700 - PubMed
  24. Endocrine. 2018 Mar;59(3):481-494 - PubMed
  25. Am J Obstet Gynecol. 1989 Oct;161(4):981-6 - PubMed
  26. Nutrition. 2011 Jul-Aug;27(7-8):782-8 - PubMed
  27. Jpn Clin Med. 2015 Dec 09;6:35-9 - PubMed
  28. Clin Exp Obstet Gynecol. 2012;39(4):512-5 - PubMed
  29. Ann Intern Med. 2015 Dec 15;163(12):889-98 - PubMed
  30. Diabetes Care. 2010 Mar;33(3):676-82 - PubMed
  31. Diabetes Res Clin Pract. 2014 Aug;105(2):223-30 - PubMed
  32. Gend Med. 2009;6 Suppl 1:109-22 - PubMed
  33. Clin Nutr Res. 2019 Apr 18;8(2):129-137 - PubMed
  34. Diabetologia. 2016 Jul;59(7):1403-1411 - PubMed
  35. Am J Obstet Gynecol. 2002 Apr;186(4):751-6 - PubMed
  36. J Diabetes Res. 2020 Apr 27;2020:3076463 - PubMed
  37. J Matern Fetal Neonatal Med. 2012 Aug;25(8):1348-53 - PubMed
  38. BMJ Open. 2016 Aug 16;6(8):e010935 - PubMed

Publication Types

Grant support