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Borsetto D, Fussey J, Fabris L, et al. HCV infection and the risk of head and neck cancer: A meta-analysis. Oral Oncol. 2020;109:104869doi: 10.1016/j.oraloncology.2020.104869.
Borsetto, D., Fussey, J., Fabris, L., Bandolin, L., Gaudioso, P., Phillips, V., Polesel, J., & Boscolo-Rizzo, P. (2020). HCV infection and the risk of head and neck cancer: A meta-analysis. Oral oncology, 109104869. https://doi.org/10.1016/j.oraloncology.2020.104869
Borsetto, Daniele, et al. "HCV infection and the risk of head and neck cancer: A meta-analysis." Oral oncology vol. 109 (2020): 104869. doi: https://doi.org/10.1016/j.oraloncology.2020.104869
Borsetto D, Fussey J, Fabris L, Bandolin L, Gaudioso P, Phillips V, Polesel J, Boscolo-Rizzo P. HCV infection and the risk of head and neck cancer: A meta-analysis. Oral Oncol. 2020 Jun 26;109:104869. doi: 10.1016/j.oraloncology.2020.104869. Epub 2020 Jun 26. PMID: 32599500.
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Oral Oncol. 2020 Jun 26;109:104869. doi: 10.1016/j.oraloncology.2020.104869. Epub 2020 Jun 26.

HCV infection and the risk of head and neck cancer: A meta-analysis.

Oral oncology

Daniele Borsetto, Jonathan Fussey, Luca Fabris, Luigia Bandolin, Piergiorgio Gaudioso, Veronica Phillips, Jerry Polesel, Paolo Boscolo-Rizzo

Affiliations

  1. Department of Otolaryngology, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
  2. Department of Otolaryngology, Royal Devon and Exeter Hospital, Exeter, United Kingdom.
  3. Department of Molecular Medicine, University of Padova, Padova, Italy; Liver Center and Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  4. Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, Italy.
  5. University of Cambridge Medical Library, Cambridge, United Kingdom.
  6. Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. Electronic address: [email protected].
  7. Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, Italy. Electronic address: [email protected].

PMID: 32599500 DOI: 10.1016/j.oraloncology.2020.104869

Abstract

Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection and HNSCC. After screening citations from literature search, eight observational studies investigating the association between HCV and cancer(s) of either oral cavity, oropharynx, hypopharynx or larynx were included. For each cancer site, risk ratios from individual studies were displayed in forest plots; pooled risk ratios (RR) and corresponding confidence intervals (CI) were calculated. A significant association was found between HCV infection and cancers of the oral cavity (RR = 2.13; 95%: 1.61-2.83), oropharynx (RR = 1.81; 95% CI: 1.21-2.72), and larynx (RR = 2.57; 95% CI: 1.11-5.94). A similar picture emerged for hypopharyngeal cancer, though this result did not fully reach statistical significance because of the small number of available studies (RR = 2.15; 95% CI: 0.73-6.31). These findings remained similar after exclusion of patients with HIV co-infection. Our results highlighted the importance of surveillance of the upper aerodigestive tract in patients with known chronic HCV infections in order to enable HNSCC early diagnosis. In addition, they could be a reminder of the possibility of undiagnosed HCV infection to the clinicians treating HNSCC.

Copyright © 2020 Elsevier Ltd. All rights reserved.

Keywords: Cancer risk; Head and neck cancer; Hepatitis C virus; Laryngeal cancer; Oral cancer; Oropharyngeal cancer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

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