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Catanzaro M, Lanni C, Basagni F, et al. . Front Pharmacol. 2020;11:844doi: 10.3389/fphar.2020.00844.
Catanzaro, M., Lanni, C., Basagni, F., Rosini, M., Govoni, S., & Amadio, M. (2020). . Frontiers in pharmacology, 11844. https://doi.org/10.3389/fphar.2020.00844
Catanzaro, Michele, et al. "." Frontiers in pharmacology vol. 11 (2020): 844. doi: https://doi.org/10.3389/fphar.2020.00844
Catanzaro M, Lanni C, Basagni F, Rosini M, Govoni S, Amadio M. . Front Pharmacol. 2020 Jun 05;11:844. doi: 10.3389/fphar.2020.00844. eCollection 2020. PMID: 32581803; PMCID: PMC7291861.
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Front Pharmacol. 2020 Jun 05;11:844. doi: 10.3389/fphar.2020.00844. eCollection 2020.

[No title available]

Frontiers in pharmacology

Michele Catanzaro, Cristina Lanni, Filippo Basagni, Michela Rosini, Stefano Govoni, Marialaura Amadio

Affiliations

  1. Section of Pharmacology, Department of Drug Sciences, University of Pavia, Pavia, Italy.
  2. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.

PMID: 32581803 PMCID: PMC7291861 DOI: 10.3389/fphar.2020.00844

Abstract

Age-related macular degeneration (AMD) is a common disease with a multifactorial aetiology, still lacking effective and curative therapies. Among the early events triggering AMD is the deterioration of the retinal pigment epithelium (RPE), whose fundamental functions assure good health of the retina. RPE is physiologically exposed to high levels of oxidative stress during its lifespan; thus, the integrity and well-functioning of its antioxidant systems are crucial to maintain RPE homeostasis. Among these defensive systems, the Nrf2-pathway plays a primary role. Literature evidence suggests that, in aged and especially in AMD RPE, there is an imbalance between the increased pro-oxidant stress, and the impaired endogenous detoxifying systems, finally reverberating on RPE functions and survival. In this

Copyright © 2020 Catanzaro, Lanni, Basagni, Rosini, Govoni and Amadio.

Keywords: HO1; Nrf2; age-related macular degeneration (AMD); cytoprotection; oxidative stress; p62; pharmacological modulation; retinal pigment epithelium (RPE)

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