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Mortimer JE, Kruper L, Cianfrocca M, et al. Use of HER2-Directed Therapy in Metastatic Breast Cancer and How Community Physicians Collaborate to Improve Care. J Clin Med. 2020;9(6)doi: 10.3390/jcm9061984.
Mortimer, J. E., Kruper, L., Cianfrocca, M., Lavasani, S., Liu, S., Tank-Patel, N., Sedrak, M., Smith, W., Stewart, D., Waisman, J., Yeon, C., Wang, T., & Yuan, Y. (2020). Use of HER2-Directed Therapy in Metastatic Breast Cancer and How Community Physicians Collaborate to Improve Care. Journal of clinical medicine, 9(6), . https://doi.org/10.3390/jcm9061984
Mortimer, Joanne E, et al. "Use of HER2-Directed Therapy in Metastatic Breast Cancer and How Community Physicians Collaborate to Improve Care." Journal of clinical medicine vol. 9,6 (2020). doi: https://doi.org/10.3390/jcm9061984
Mortimer JE, Kruper L, Cianfrocca M, Lavasani S, Liu S, Tank-Patel N, Sedrak M, Smith W, Stewart D, Waisman J, Yeon C, Wang T, Yuan Y. Use of HER2-Directed Therapy in Metastatic Breast Cancer and How Community Physicians Collaborate to Improve Care. J Clin Med. 2020 Jun 24;9(6). doi: 10.3390/jcm9061984. PMID: 32599960; PMCID: PMC7355741.
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J Clin Med. 2020 Jun 24;9(6). doi: 10.3390/jcm9061984.

Use of HER2-Directed Therapy in Metastatic Breast Cancer and How Community Physicians Collaborate to Improve Care.

Journal of clinical medicine

Joanne E Mortimer, Laura Kruper, Mary Cianfrocca, Sayeh Lavasani, Sariah Liu, Niki Tank-Patel, Mina Sedrak, Wade Smith, Daphne Stewart, James Waisman, Christina Yeon, Tina Wang, Yuan Yuan

Affiliations

  1. Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
  2. Department of Surgery, Division of Breast Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

PMID: 32599960 PMCID: PMC7355741 DOI: 10.3390/jcm9061984

Abstract

The development of new HER2-directed therapies has resulted in a significant prolongation of survival for women with metastatic HER2-positive breast cancer. Discoveries in the laboratory inform clinical trials which are the basis for improving the standard of care and are also the backbone for quality improvement. Clinical trials can be completed more rapidly by expanding trial enrollment to community sites. In this article we review some of the challenges in treating metastatic breast cancer with HER2-directed therapies and our strategies for incorporating our community partners into the research network.

Keywords: HER2-directed therapy; breast cancer; community; research

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