Stud Health Technol Inform. 2020 Jun 26;272:334-337. doi: 10.3233/SHTI200563.

Towards Intelligent Integration and Sharing of Stem Cell Research Data.

Studies in health technology and informatics

Kirill Borziak, Tianye Qi, John Erol Evangelista, Daniel J B Clarke, Avi Ma'ayan, Joseph Finkelstein

PMID: 32604670 DOI: 10.3233/SHTI200563

Abstract

Advancements in regenerative medicine have brought to the fore the need for increased standardization and sharing of stem cell product characterization to help drive these innovative interventions toward public availability. Although numerous attempts have been made to store this data, there is still a lack of a platform that incorporates heterogeneous stem cell information into a harmonized project-based framework. The aim of this project was to introduce and pilot-test an intelligent informatics solution which integrates diverse stem cell product characteristics with study subject and omics information. In the resulting platform, heterogeneous data is validated using predefined ontologies and stored in a NoSQL repository. Pilot-testing was performed on nine sponsored stem cell projects conducting preclinical and intervention evaluations. The pilot-testing demonstrated the robustness of the proposed platform, by seamlessly harmonizing diverse common data elements, and the potential of this platform for driving knowledge generation from the aggregation of this shared data.

Keywords: Data aggregation; common data elements; regenerative medicine; stem cells

MeSH terms

• Stem Cell Research*

Publication Types

• Journal Article