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Emmett M. Metabolic Alkalosis: A Brief Pathophysiologic Review. Clin J Am Soc Nephrol. 2020;15(12):1848-1856doi: 10.2215/CJN.16041219.
Emmett, M. (2020). Metabolic Alkalosis: A Brief Pathophysiologic Review. Clinical journal of the American Society of Nephrology : CJASN, 15(12), 1848-1856. https://doi.org/10.2215/CJN.16041219
Emmett, Michael. "Metabolic Alkalosis: A Brief Pathophysiologic Review." Clinical journal of the American Society of Nephrology : CJASN vol. 15,12 (2020): 1848-1856. doi: https://doi.org/10.2215/CJN.16041219
Emmett M. Metabolic Alkalosis: A Brief Pathophysiologic Review. Clin J Am Soc Nephrol. 2020 Dec 07;15(12):1848-1856. doi: 10.2215/CJN.16041219. Epub 2020 Jun 25. PMID: 32586924; PMCID: PMC7769018.
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Clin J Am Soc Nephrol. 2020 Dec 07;15(12):1848-1856. doi: 10.2215/CJN.16041219. Epub 2020 Jun 25.

Metabolic Alkalosis: A Brief Pathophysiologic Review.

Clinical journal of the American Society of Nephrology : CJASN

Michael Emmett

Affiliations

  1. Divisions of Internal Medicine and Nephrology, Department of Medicine, Baylor University Medical Center at Dallas, Dallas, Texas [email protected].

PMID: 32586924 PMCID: PMC7769018 DOI: 10.2215/CJN.16041219

Abstract

Metabolic alkalosis is a very commonly encountered acid-base disorder that may be generated by a variety of exogenous and/or endogenous, pathophysiologic mechanisms. Multiple mechanisms are also responsible for the persistence, or maintenance, of metabolic alkalosis. Understanding these generation and maintenance mechanisms helps direct appropriate intervention and correction of this disorder. The framework utilized in this review is based on the ECF volume-centered approach popularized by Donald Seldin and Floyd Rector in the 1970s.  Although many subsequent scientific discoveries have advanced our understanding of the pathophysiology of metabolic alkalosis, that framework continues to be a valuable and relatively straightforward diagnostic and therapeutic model.

Copyright © 2020 by the American Society of Nephrology.

Keywords: alkalosis; bicarbonates; electrolytes; musculoskeletal abnormalities

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