Display options
Cite
Martínez-Herrera M, Abad-Jiménez Z, Silvestre FJ, et al. Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects with Periodontitis: A Pilot Study. J Clin Med. 2020;9(7)doi: 10.3390/jcm9072117.
Martínez-Herrera, M., Abad-Jiménez, Z., Silvestre, F. J., López-Domènech, S., Márquez-Arrico, C. F., Silvestre-Rangil, J., Víctor, V. M., & Rocha, M. (2020). Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects with Periodontitis: A Pilot Study. Journal of clinical medicine, 9(7), . https://doi.org/10.3390/jcm9072117
Martínez-Herrera, Mayte, et al. "Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects with Periodontitis: A Pilot Study." Journal of clinical medicine vol. 9,7 (2020). doi: https://doi.org/10.3390/jcm9072117
Martínez-Herrera M, Abad-Jiménez Z, Silvestre FJ, López-Domènech S, Márquez-Arrico CF, Silvestre-Rangil J, Víctor VM, Rocha M. Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects with Periodontitis: A Pilot Study. J Clin Med. 2020 Jul 04;9(7). doi: 10.3390/jcm9072117. PMID: 32635585; PMCID: PMC7408850.
Copy Download .nbib Format: NLM
Share it on

J Clin Med. 2020 Jul 04;9(7). doi: 10.3390/jcm9072117.

Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects with Periodontitis: A Pilot Study.

Journal of clinical medicine

Mayte Martínez-Herrera, Zaida Abad-Jiménez, Francisco Javier Silvestre, Sandra López-Domènech, Cecilia Fabiana Márquez-Arrico, Javier Silvestre-Rangil, Víctor M Víctor, Milagros Rocha

Affiliations

  1. Department of Stomatology, University of Valencia, Gascó i Oliag 1, 46010 Valencia, Spain.
  2. Department of Stomatology, University Hospital Doctor Peset-FISABIO, Av. Gaspar Aguilar 90, 46017 Valencia, Spain.
  3. Department of Endocrinology and Nutrition, University Hospital Doctor Peset-FISABIO, Av. Gaspar Aguilar 90, 46017 Valencia, Spain.
  4. CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av. Blasco Ibáñez 15, 46010 Valencia, Spain.
  5. Department of Physiology, University of Valencia, Av. Blasco Ibáñez 15, 46010 Valencia, Spain.

PMID: 32635585 PMCID: PMC7408850 DOI: 10.3390/jcm9072117

Abstract

AIM: The primary objective of this pilot study was to evaluate the effect of non-surgical periodontal treatment. The secondary aim was to evaluate the effect of dietary therapy on both parameters of oxidative stress in leukocytes and leukocyte-endothelial cell interactions in an obese population.

METHODS: This was a pilot study with a before-and-after design. Forty-nine obese subjects with periodontitis were randomized by means of the minimization method and assigned to one of two groups, one of which underwent dietary therapy while the other did not. All the subjects underwent non-surgical periodontal treatment. We determined periodontal, inflammatory and oxidative stress parameters-total reactive oxygen species (ROS), superoxide production, intracellular Ca

RESULTS: Periodontal treatment improved the periodontal health of all the patients, with a reduction in serum retinol-binding protein 4 (RBP4), total superoxide production and cytosolic Ca

CONCLUSIONS: Whereas non-surgical periodontal treatment induces an improvement in leukocyte homeostasis, dietary therapy as an adjuvant reduces systemic inflammation and increases antioxidant status which, in turn, modulates leukocyte-endothelium dynamics.

Keywords: dietary therapy; endothelial dysfunction; obesity; oxidative stress; periodontal treatment; periodontitis; reactive oxygen species

References

  1. Eur J Clin Invest. 2018 Aug;48(8):e12985 - PubMed
  2. J Periodontol. 2009 Jun;80(6):901-6 - PubMed
  3. Atherosclerosis. 2015 Jan;238(1):45-51 - PubMed
  4. Atherosclerosis. 2015 Jun;240(2):335-44 - PubMed
  5. Clin Exp Immunol. 2007 Feb;147(2):255-64 - PubMed
  6. Eur J Pharmacol. 2015 Oct 15;765:355-65 - PubMed
  7. Clin Oral Investig. 2017 Sep;21(7):2319-2325 - PubMed
  8. Nat Rev Endocrinol. 2012 Oct;8(10):570-2 - PubMed
  9. Oral Dis. 2018 Oct;24(7):1349-1357 - PubMed
  10. PLoS One. 2014 Mar 20;9(3):e92739 - PubMed
  11. Int J Obes (Lond). 2019 Nov;43(11):2200-2209 - PubMed
  12. Atherosclerosis. 2009 May;204(1):23-5 - PubMed
  13. Periodontol 2000. 2007;43:160-232 - PubMed
  14. Nutr Neurosci. 2014 Sep;17(5):214-21 - PubMed
  15. J Clin Periodontol. 2018 Dec;45(12):1448-1457 - PubMed
  16. Arch Oral Biol. 2016 Feb;62:80-5 - PubMed
  17. Lancet Diabetes Endocrinol. 2018 Dec;6(12):954-965 - PubMed
  18. Circulation. 2004 Sep 21;110(12):1564-71 - PubMed
  19. Front Physiol. 2017 May 30;8:351 - PubMed
  20. Front Physiol. 2017 Nov 13;8:910 - PubMed
  21. Med Clin (Barc). 2007 Feb 10;128(5):184-96; quiz 1 p following 200 - PubMed
  22. J Periodontol. 2013 Jan;84(1):13-23 - PubMed
  23. J Clin Periodontol. 2018 Mar;45(3):345-353 - PubMed
  24. Mol Metab. 2019 Jan;19:24-33 - PubMed
  25. Annu Rev Physiol. 2010;72:219-46 - PubMed
  26. Niger Med J. 2019 May-Jun;60(3):133-137 - PubMed
  27. Cell Death Dis. 2010 Jul 15;1:e54 - PubMed
  28. Exp Biol Med (Maywood). 2013 Jun;238(6):713-22 - PubMed
  29. Nat Rev Cardiol. 2009 Jun;6(6):399-409 - PubMed
  30. N Engl J Med. 2007 Mar 1;356(9):911-20 - PubMed
  31. Free Radic Biol Med. 2015 Jan;78:190-201 - PubMed
  32. Biochem J. 2009 Jan 1;417(1):1-13 - PubMed
  33. J Clin Periodontol. 2018 Dec;45(12):1429-1439 - PubMed
  34. J Membr Biol. 2016 Aug;249(4):437-47 - PubMed
  35. Front Physiol. 2017 Aug 23;8:600 - PubMed
  36. J Periodontol. 2012 Jun;83(6):684-9 - PubMed
  37. Atherosclerosis. 2012 May;222(1):196-201 - PubMed
  38. Atherosclerosis. 2014 Sep;236(1):39-46 - PubMed
  39. J Clin Periodontol. 2016 Aug;43(8):652-8 - PubMed
  40. J Clin Periodontol. 2018 Jun;45 Suppl 20:S149-S161 - PubMed
  41. J Am Dent Assoc. 2017 May;148(5):308-318 - PubMed
  42. Aust Dent J. 2010 Mar;55(1):70-8 - PubMed
  43. J Periodontol. 2017 Aug;88(8):778-787 - PubMed
  44. Hypertension. 2014 Oct;64(4):702-8 - PubMed
  45. J Dent Res. 2007 Aug;86(8):718-22 - PubMed
  46. J Periodontol. 2017 May;88(5):493-501 - PubMed
  47. J Clin Periodontol. 2018 Mar;45(3):336-344 - PubMed
  48. J Periodontol. 2018 Feb;89(2):176-185 - PubMed
  49. Clin Oral Investig. 2016 Jul;20(6):1263-9 - PubMed
  50. J Clin Periodontol. 2009 Jul;36 Suppl 10:15-9 - PubMed
  51. Clin Oral Investig. 2017 Jul;21(6):1961-1969 - PubMed
  52. Circulation. 2013 May 14;127(19):1938-47 - PubMed
  53. Circ Res. 2008 Feb 29;102(4):401-14 - PubMed

Publication Types