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Hadidi Zavareh AH, Haji Khani R, Pakpour B, et al. Probiotic treatment differentially affects the behavioral and electrophysiological aspects in ethanol exposed animals. Iran J Basic Med Sci. 2020;23(6):776-780doi: 10.22038/ijbms.2020.41685.9846.
Hadidi Zavareh, A. H., Haji Khani, R., Pakpour, B., Soheili, M., & Salami, M. (2020). Probiotic treatment differentially affects the behavioral and electrophysiological aspects in ethanol exposed animals. Iranian journal of basic medical sciences, 23(6), 776-780. https://doi.org/10.22038/ijbms.2020.41685.9846
Hadidi Zavareh, Amir Hosein, et al. "Probiotic treatment differentially affects the behavioral and electrophysiological aspects in ethanol exposed animals." Iranian journal of basic medical sciences vol. 23,6 (2020): 776-780. doi: https://doi.org/10.22038/ijbms.2020.41685.9846
Hadidi Zavareh AH, Haji Khani R, Pakpour B, Soheili M, Salami M. Probiotic treatment differentially affects the behavioral and electrophysiological aspects in ethanol exposed animals. Iran J Basic Med Sci. 2020 Jun;23(6):776-780. doi: 10.22038/ijbms.2020.41685.9846. PMID: 32695294; PMCID: PMC7351434.
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Iran J Basic Med Sci. 2020 Jun;23(6):776-780. doi: 10.22038/ijbms.2020.41685.9846.

Probiotic treatment differentially affects the behavioral and electrophysiological aspects in ethanol exposed animals.

Iranian journal of basic medical sciences

Amir Hosein Hadidi Zavareh, Ramin Haji Khani, Bahareh Pakpour, Masoud Soheili, Mahmoud Salami

Affiliations

  1. Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran.
  2. Department of Biology, Faculty of Sciences Central Tehran Branch, Islamic Azad University, Tehran, Iran.
  3. Physiology Research Center, Institute for Basic Sciences, Kashan University of medical sciences, Kashan, Iran.

PMID: 32695294 PMCID: PMC7351434 DOI: 10.22038/ijbms.2020.41685.9846

Abstract

OBJECTIVES: Harmful effects of alcohol on brain function including cognitive phenomena are well known. Damage to gut microbiota is linked to neurological disorders. Evidence indicates that intestinal flora can be strengthened by probiotic bacteria. In this study, we evaluated the effect of probiotics administration on LTP induction in rats receiving ethanol.

MATERIALS AND METHODS: To assess if probiotic treatment influences toxic effect of ethanol, vehicle (CON) and probiotic treated (CON+PRO) control rats, and chronic ethanol (CE) exposed and CE probiotic treated (CE+PRO) animals were entered into the experiments. Shuttle box test and

RESULTS: Ethanol impaired memory in the CE rats. It also diminished the slope size of fEPSPs and prevented LTP induction. While the probiotic supplementation improved memory in the CE+PRO rats, it did not influence synaptic transmission in these animals.

CONCLUSION: Conclusively, behavioral but not electrophysiological aspect of cognition is sensitive to probiotic treatment in the ethanol exposed animals.

Keywords: Ethanol; LTP; Memory; Probiotics; Rat

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