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Incandela F, Feraco P, Putortì V, et al. Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs. Eur J Radiol Open. 2020;7:100242doi: 10.1016/j.ejro.2020.100242.
Incandela, F., Feraco, P., Putortì, V., Geraci, L., Salvaggio, G., Sarno, C., La Tona, G., Lasio, G., & Gagliardo, C. (2020). Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs. European journal of radiology open, 7100242. https://doi.org/10.1016/j.ejro.2020.100242
Incandela, Francesca, et al. "Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs." European journal of radiology open vol. 7 (2020): 100242. doi: https://doi.org/10.1016/j.ejro.2020.100242
Incandela F, Feraco P, Putortì V, Geraci L, Salvaggio G, Sarno C, La Tona G, Lasio G, Gagliardo C. Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs. Eur J Radiol Open. 2020 Jun 20;7:100242. doi: 10.1016/j.ejro.2020.100242. eCollection 2020. PMID: 32695849; PMCID: PMC7365899.
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Eur J Radiol Open. 2020 Jun 20;7:100242. doi: 10.1016/j.ejro.2020.100242. eCollection 2020.

Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs.

European journal of radiology open

Francesca Incandela, Paola Feraco, Valeria Putortì, Laura Geraci, Giuseppe Salvaggio, Caterina Sarno, Giuseppe La Tona, Giovanni Lasio, Cesare Gagliardo

Affiliations

  1. Section of Radiological Sciences, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy.
  2. Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
  3. Department of Neuroradiology, Ospedale S. Chiara, Azienda Provinciale Per i Servizi Sanitari, Trento, Italy.
  4. Department of Diagnostic Imaging and Interventional Neurosciences, University-Hospital P. Giaccone of Palermo, Palermo, Italy.
  5. Department of Neurosurgery, Humanitas Clinical and Research Center IRCCS, Rozzano, (MI), Italy.

PMID: 32695849 PMCID: PMC7365899 DOI: 10.1016/j.ejro.2020.100242

Abstract

Pituitary carcinomas (PCa) are extremely rare, indistinguishable from pituitary adenomas on histopathological grounds and have a poor prognosis. Most PCa start as PRL or ACTH secreting tumors in males, with relapsing invasive behaviour, refractoriness to medical and radiotherapy and increasing hormonal levels. The presence of distant metastases is still required for the diagnosis of PCa. The association with genetic endocrine diseases must be taken into account, since it adds further risk of evolution towards malignancy. Intradural spinal metastases have also been reported, so a complete craniospinal MR evaluation is recommended, when clinically indicated. We report a case of PCa, associated with MEN1 syndrome, with evidence of meningeal spread to the tentorium cerebelli, clival dura and spinal drop metastases mimicking spinal nerves schwannomas.

© 2020 The Authors.

Keywords: Ki-67 antigen; Magnetic resonance imaging, MRI; Neoplasm metastasis; Pituitary adenoma; Pituitary carcinoma; Pituitary neoplasms

Conflict of interest statement

The authors declare that they have no conflict of interest.

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