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Shimy KJ, Feldman HA, Klein GL, et al. Effects of Dietary Carbohydrate Content on Circulating Metabolic Fuel Availability in the Postprandial State. J Endocr Soc. 2020;4(7):bvaa062doi: 10.1210/jendso/bvaa062.
Shimy, K. J., Feldman, H. A., Klein, G. L., Bielak, L., Ebbeling, C. B., & Ludwig, D. S. (2020). Effects of Dietary Carbohydrate Content on Circulating Metabolic Fuel Availability in the Postprandial State. Journal of the Endocrine Society, 4(7), bvaa062. https://doi.org/10.1210/jendso/bvaa062
Shimy, Kim J, et al. "Effects of Dietary Carbohydrate Content on Circulating Metabolic Fuel Availability in the Postprandial State." Journal of the Endocrine Society vol. 4,7 (2020): bvaa062. doi: https://doi.org/10.1210/jendso/bvaa062
Shimy KJ, Feldman HA, Klein GL, Bielak L, Ebbeling CB, Ludwig DS. Effects of Dietary Carbohydrate Content on Circulating Metabolic Fuel Availability in the Postprandial State. J Endocr Soc. 2020 May 26;4(7):bvaa062. doi: 10.1210/jendso/bvaa062. eCollection 2020 Jul 01. PMID: 32666008; PMCID: PMC7326475.
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J Endocr Soc. 2020 May 26;4(7):bvaa062. doi: 10.1210/jendso/bvaa062. eCollection 2020 Jul 01.

Effects of Dietary Carbohydrate Content on Circulating Metabolic Fuel Availability in the Postprandial State.

Journal of the Endocrine Society

Kim J Shimy, Henry A Feldman, Gloria L Klein, Lisa Bielak, Cara B Ebbeling, David S Ludwig

Affiliations

  1. New Balance Foundation Obesity Prevention Center, Boston Children's Hospital, Boston, Massachusetts.
  2. Division of Endocrinology, Children's National Medical Center, Washington, DC.
  3. Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts.
  4. Harvard Medical School, Boston, Massachusetts.

PMID: 32666008 PMCID: PMC7326475 DOI: 10.1210/jendso/bvaa062

Abstract

CONTEXT: According to the carbohydrate-insulin model of obesity, an elevated insulin-to-glucagon ratio in response to a high-carbohydrate diet directs metabolic fuels toward storage, resulting in lower circulating energy.

OBJECTIVE: To determine differences in total circulating energy post-meal related to dietary carbohydrate.

DESIGN: Ancillary study within the Framingham State Food Study.

SETTING: University community.

PARTICIPANTS: 29 adults (aged 20 to 65 years) with overweight or obesity (body mass index ≥25 kg/m

INTERVENTION: After achieving 10% to 14% weight loss on a run-in diet, participants were randomized to weight-loss-maintenance test diets varying in carbohydrate content (high-carbohydrate, 60% of total energy, n = 11; moderate-carbohydrate, 40%, n = 8; low-carbohydrate, 20%, n = 10) and controlled for protein (20%). During 24-hour metabolic ward admissions between 10 and 15 weeks on the test diets, metabolic fuels and hormones were measured.

MAIN OUTCOME MEASURE: Energy availability (EA) based on energy content of blood glucose, beta-hydroxybutyrate, and free fatty acids, in the late postprandial period (180 to 300 minutes). Insulin at 30 minutes into the test meal (Meal Insulin-30) was measured as an effect modifier.

RESULTS: Insulin-to-glucagon ratio was 7-fold higher in participants on the high- vs low-carbohydrate diet (2.5 and 0.36, respectively). Late postprandial EA was 0.58 kcal/L lower on the high- vs low-carbohydrate diet (

CONCLUSIONS: During weight-loss maintenance on a high-carbohydrate diet, late postprandial EA is reduced, consistent with the carbohydrate-insulin model.

© Endocrine Society 2020.

Keywords: beta-hydroxybutyrate; carbohydrate; fatty acids; glucose; insulin; obesity

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