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Noda H, Okazaki M, Joyashiki E, et al. Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long-Acting PTH Analog (LA-PTH). JBMR Plus. 2020;4(7):e10367doi: 10.1002/jbm4.10367.
Noda, H., Okazaki, M., Joyashiki, E., Tamura, T., Kawabe, Y., Khatri, A., Jueppner, H., Potts, J. T., Gardella, T. J., & Shimizu, M. (2020). Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long-Acting PTH Analog (LA-PTH). JBMR plus, 4(7), e10367. https://doi.org/10.1002/jbm4.10367
Noda, Hiroshi, et al. "Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long-Acting PTH Analog (LA-PTH)." JBMR plus vol. 4,7 (2020): e10367. doi: https://doi.org/10.1002/jbm4.10367
Noda H, Okazaki M, Joyashiki E, Tamura T, Kawabe Y, Khatri A, Jueppner H, Potts JT, Gardella TJ, Shimizu M. Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long-Acting PTH Analog (LA-PTH). JBMR Plus. 2020 May 30;4(7):e10367. doi: 10.1002/jbm4.10367. eCollection 2020 Jul. PMID: 32666018; PMCID: PMC7340446.
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JBMR Plus. 2020 May 30;4(7):e10367. doi: 10.1002/jbm4.10367. eCollection 2020 Jul.

Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long-Acting PTH Analog (LA-PTH).

JBMR plus

Hiroshi Noda, Makoto Okazaki, Eri Joyashiki, Tatsuya Tamura, Yoshiki Kawabe, Ashok Khatri, Harald Jueppner, John T Potts, Thomas J Gardella, Masaru Shimizu

Affiliations

  1. Research Division Chugai Pharmaceutical Co., Ltd Shizuoka Japan.
  2. Endocrine Unit Massachusetts General Hospital Boston MA USA.

PMID: 32666018 PMCID: PMC7340446 DOI: 10.1002/jbm4.10367

Abstract

Prolonged signaling at the parathyroid hormone receptor 1 (PTHR1) correlates with the capacity of a ligand to bind to a G protein-independent receptor conformation (R

© 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

Keywords: ANIMAL MODELS, PTH/ViT D/FGF23; CELL/TISSUE SIGNALING; DISORDERS OF CALCIUM/PHOSPHATE METABOLISM; ENDOCRINE PATHWAYS; HORMONE REPLACEMENT/RECEPTOR MODULATORS; PARATHYROID‐RELATED DISORDERS; THERAPEUTICS, PRECLINICAL STUDIES

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