Display options
Cite
Rangaraju M, Turner AM. Why is Disease Penetration so Variable in Alpha-1 Antitrypsin Deficiency? The Contribution of Environmental Factors. Chronic Obstr Pulm Dis. 2020;7(3):280-289doi: 10.15326/jcopdf.7.3.2019.0177.
Rangaraju, M., & Turner, A. M. (2020). Why is Disease Penetration so Variable in Alpha-1 Antitrypsin Deficiency? The Contribution of Environmental Factors. Chronic obstructive pulmonary diseases (Miami, Fla.), 7(3), 280-289. https://doi.org/10.15326/jcopdf.7.3.2019.0177
Rangaraju, Madhu, and Turner, Alice M. "Why is Disease Penetration so Variable in Alpha-1 Antitrypsin Deficiency? The Contribution of Environmental Factors." Chronic obstructive pulmonary diseases (Miami, Fla.) vol. 7,3 (2020): 280-289. doi: https://doi.org/10.15326/jcopdf.7.3.2019.0177
Rangaraju M, Turner AM. Why is Disease Penetration so Variable in Alpha-1 Antitrypsin Deficiency? The Contribution of Environmental Factors. Chronic Obstr Pulm Dis. 2020 Jul;7(3):280-289. doi: 10.15326/jcopdf.7.3.2019.0177. PMID: 32698254; PMCID: PMC7857715.
Copy Download .nbib Format: NLM
Share it on

Chronic Obstr Pulm Dis. 2020 Jul;7(3):280-289. doi: 10.15326/jcopdf.7.3.2019.0177.

Why is Disease Penetration so Variable in Alpha-1 Antitrypsin Deficiency? The Contribution of Environmental Factors.

Chronic obstructive pulmonary diseases (Miami, Fla.)

Madhu Rangaraju, Alice M Turner

Affiliations

  1. University Hospitals, Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom.
  2. Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom.

PMID: 32698254 PMCID: PMC7857715 DOI: 10.15326/jcopdf.7.3.2019.0177

Abstract

Environmental influences on clinical phenotype in alpha-1 antitrypsin deficiency (AATD) include cigarette smoke, occupational exposures, airway/sputum bacteria and outdoor air pollution. This narrative review describes the impact of the major environmental exposures and summarizes their effect on clinical phenotype and outcomes. In general, patients with AATD are more susceptible to pulmonary damage as a result of the relatively unopposed action of neutrophil elastase, in the context of neutrophilic inflammation stimulated by environmental factors. However, the amount of phenotypic variability explicable by environmental factors is insufficient to account for the wide range of clinical presentations observed, suggesting that a combination of genetic and environmental factors is likely to be responsible.

JCOPDF © 2020.

Keywords: air pollution; alpha-1 antitrypsin deficiency; cigarette smoking; microbiota; occupational exposure

References

  1. Am J Ind Med. 1994 Apr;25(4):551-8 - PubMed
  2. Int J Chron Obstruct Pulmon Dis. 2018 Feb 21;13:645-652 - PubMed
  3. Eur Respir J. 2010 Feb;35(2):295-302 - PubMed
  4. Scand J Work Environ Health. 2004 Jun;30(3):241-8 - PubMed
  5. Eur Respir J. 2016 Apr;47(4):1082-92 - PubMed
  6. Am J Epidemiol. 2009 Oct 15;170(8):1005-13 - PubMed
  7. Am J Respir Crit Care Med. 2014 Feb 15;189(4):419-27 - PubMed
  8. Am J Pathol. 2005 Feb;166(2):377-86 - PubMed
  9. Ann Intern Med. 1989 Dec 15;111(12):982-91 - PubMed
  10. Thorax. 2015 Oct;70(10):939-45 - PubMed
  11. PLoS One. 2010 Jan 05;5(1):e8578 - PubMed
  12. Am J Respir Cell Mol Biol. 2010 Mar;42(3):304-11 - PubMed
  13. Lancet Glob Health. 2017 Mar;5(3):e277-e289 - PubMed
  14. Int J Chron Obstruct Pulmon Dis. 2006;1(4):485-92 - PubMed
  15. Trends Mol Med. 2014 Feb;20(2):105-15 - PubMed
  16. Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1592-8 - PubMed
  17. PLoS One. 2011 Feb 22;6(2):e16384 - PubMed
  18. Respir Res. 2008 Jul 11;9:52 - PubMed
  19. Eur Respir J. 2009 Aug;34(2):346-53 - PubMed
  20. Thorax. 2004 Oct;59(10):843-9 - PubMed
  21. Chest. 2010 Nov;138(5):1116-24 - PubMed
  22. Respir Res. 2019 Dec 2;20(1):269 - PubMed
  23. COPD. 2015 May;12 Suppl 1:2-9 - PubMed
  24. Respir Med. 2002 Nov;96(11):872-80 - PubMed
  25. Am J Respir Crit Care Med. 2009 Jul 1;180(1):3-10 - PubMed
  26. Toxicol Appl Pharmacol. 1996 May;138(1):176-85 - PubMed
  27. Eur J Nucl Med Mol Imaging. 2011 May;38(5):911-9 - PubMed
  28. Am J Respir Crit Care Med. 1999 Dec;160(6):1968-75 - PubMed
  29. Eur Respir J. 2004 May;23(5):685-91 - PubMed
  30. Radiology. 2020 Apr;295(1):218-226 - PubMed
  31. Int J Chron Obstruct Pulmon Dis. 2019 May 23;14:1075-1083 - PubMed
  32. Am J Respir Crit Care Med. 2011 May 1;183(9):1176-86 - PubMed
  33. Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 2):S49-52 - PubMed
  34. Occup Environ Med. 2010 Aug;67(8):556-61 - PubMed
  35. Thorax. 1998 Nov;53(11):939-43 - PubMed
  36. Occup Environ Med. 2014 Apr;71(4):234-40 - PubMed
  37. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):553-8 - PubMed
  38. Respir Med. 2017 Aug;129:8-15 - PubMed
  39. Am J Ind Med. 1993 Aug;24(2):207-22 - PubMed
  40. Thorax. 2012 Aug;67(8):669-74 - PubMed
  41. J Pediatr Gastroenterol Nutr. 2006 Jul;43 Suppl 1:S30-5 - PubMed
  42. Clin Sci (Lond). 1983 Oct;65(4):373-81 - PubMed
  43. Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1922-5 - PubMed
  44. Toxicol Lett. 2002 Nov 15;136(1):9-17 - PubMed
  45. Respir Med. 2017 Sep;130:1-8 - PubMed
  46. Am J Respir Cell Mol Biol. 2011 Aug;45(2):261-9 - PubMed
  47. Environ Health. 2015 Jan 07;14:1 - PubMed
  48. Int J Chron Obstruct Pulmon Dis. 2016 Aug 01;11:1745-56 - PubMed
  49. Int J Chron Obstruct Pulmon Dis. 2017 May 12;12:1427-1437 - PubMed
  50. Respir Res. 2016 Mar 31;17:34 - PubMed
  51. Eur Respir J. 2019 Dec 19;54(6): - PubMed
  52. Thorax. 2011 Mar;66(3):205-10 - PubMed
  53. Eur Respir J. 2000 Jul;16(1):50-5 - PubMed
  54. Respirology. 2016 Oct;21(7):1235-42 - PubMed

Publication Types

Grant support