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Nygaard KH, Havelund JF, Nielsen TH, et al. Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A . Metabolites. 2020;10(7)doi: 10.3390/metabo10070287.
Nygaard, K. H., Havelund, J. F., Nielsen, T. H., Nordström, C. H., Færgeman, N. J., Poulsen, F. R., Gramsbergen, J. B., & Forsse, A. (2020). Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A . Metabolites, 10(7), . https://doi.org/10.3390/metabo10070287
Nygaard, Kevin H, et al. "Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A ." Metabolites vol. 10,7 (2020). doi: https://doi.org/10.3390/metabo10070287
Nygaard KH, Havelund JF, Nielsen TH, Nordström CH, Færgeman NJ, Poulsen FR, Gramsbergen JB, Forsse A. Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A . Metabolites. 2020 Jul 13;10(7). doi: 10.3390/metabo10070287. PMID: 32668656; PMCID: PMC7407637.
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Metabolites. 2020 Jul 13;10(7). doi: 10.3390/metabo10070287.

Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A .

Metabolites

Kevin H Nygaard, Jesper F Havelund, Troels H Nielsen, Carl-Henrik Nordström, Nils J Færgeman, Frantz R Poulsen, Jan Bert Gramsbergen, Axel Forsse

Affiliations

  1. Department of Neurosurgery, Odense University Hospital, University of Southern Denmark, Sdr. Boulevard 29, 5000 Odense C, Denmark.
  2. BRIDGE-Brain Researche-Inter-Disciplinary Guided Excellence, Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, 5000 Odense C, Denmark.
  3. VILLUM Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
  4. Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense C, Denmark.

PMID: 32668656 PMCID: PMC7407637 DOI: 10.3390/metabo10070287

Abstract

Mitochondrial dysfunction after transient cerebral ischemia can be monitored by cerebral microdialysis (CMD) using changes in the lactate and pyruvate concentrations and ratio. Other metabolites associated with mitochondrial (dys)function are, e.g., tricyclic acid (TCA) and purine metabolites. Ethyl pyruvate (EP) is a putative neuroprotectant, supposedly targeting mitochondrial energy metabolism, but its effect on cerebral energy metabolism has never been described using microdialysis. In this study we monitored the metabolic effects of EP in the endothelin-1 (ET-1) rat model using perfusion with

Keywords: cerebral metabolism; labeled succinate; liquid chromatography—mass spectrometry; mitochondrial dysfunction; transient ischemia

References

  1. Int J Mol Sci. 2012;13(9):11753-72 - PubMed
  2. J Neurochem. 2012 Oct;123(1):172-81 - PubMed
  3. Acta Neurochir Suppl. 2016;121:111-4 - PubMed
  4. Anesthesiology. 2007 Oct;107(4):630-40 - PubMed
  5. Acta Neurochir (Wien). 2000;142(10):1135-41; discussion 1141-2 - PubMed
  6. Crit Care Med. 2001 Aug;29(8):1513-8 - PubMed
  7. Acta Neurochir (Wien). 2016 Jul;158(7):1231-40 - PubMed
  8. Acta Neurol Scand. 2014 Sep;130(3):156-63 - PubMed
  9. Crit Care. 2016 Oct 14;20(1):277 - PubMed
  10. Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1354-62 - PubMed
  11. Acta Neurochir (Wien). 2017 Dec;159(12):2275-2277 - PubMed
  12. Metabolites. 2019 Sep 27;9(10): - PubMed
  13. FASEB J. 2008 Nov;22(11):3938-46 - PubMed
  14. J Neurol Neurosurg Psychiatry. 2014 Dec;85(12):1343-53 - PubMed
  15. J Mol Med (Berl). 2009 Apr;87(4):423-33 - PubMed
  16. Sci Rep. 2017 Feb 21;7:42891 - PubMed
  17. Behav Brain Res. 1995 Nov;71(1-2):33-49 - PubMed
  18. Neurosci Lett. 2009 Nov 6;465(1):55-60 - PubMed
  19. Front Neurol. 2017 Jun 19;8:274 - PubMed
  20. Biochem Pharmacol. 2010 Jul 15;80(2):151-9 - PubMed
  21. Int J Biochem Cell Biol. 2010 Jun;42(6):932-7 - PubMed
  22. Mol Neuropsychiatry. 2015 May;1(1):60-7 - PubMed
  23. J Neurochem. 1987 Jul;49(1):227-31 - PubMed
  24. Metabolism. 1997 Jul;46(7):801-4 - PubMed
  25. J Cereb Blood Flow Metab. 2017 Jul;37(7):2626-2638 - PubMed
  26. Sci Rep. 2019 Mar 6;9(1):3702 - PubMed
  27. Br J Pharmacol. 2011 Oct;164(4):1062-78 - PubMed
  28. Neurol Med Chir (Tokyo). 1991 Mar;31(3):129-34 - PubMed
  29. Acta Neurochir (Wien). 1998;140(4):387-95 - PubMed
  30. Int J Mol Sci. 2011;12(10):6469-501 - PubMed
  31. Neuropharmacology. 2016 May;104:105-30 - PubMed
  32. Redox Biol. 2016 Aug;8:28-42 - PubMed

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