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Voskamp C, Koevoet WJLM, Somoza RA, et al. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020;8:658doi: 10.3389/fbioe.2020.00658.
Voskamp, C., Koevoet, W. J. L. M., Somoza, R. A., Caplan, A. I., Lefebvre, V., van Osch, G. J. V. M., & Narcisi, R. (2020). Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Frontiers in bioengineering and biotechnology, 8658. https://doi.org/10.3389/fbioe.2020.00658
Voskamp, Chantal, et al. "Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment." Frontiers in bioengineering and biotechnology vol. 8 (2020): 658. doi: https://doi.org/10.3389/fbioe.2020.00658
Voskamp C, Koevoet WJLM, Somoza RA, Caplan AI, Lefebvre V, van Osch GJVM, Narcisi R. Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment. Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658. eCollection 2020. PMID: 32714905; PMCID: PMC7344141.
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Front Bioeng Biotechnol. 2020 Jun 30;8:658. doi: 10.3389/fbioe.2020.00658. eCollection 2020.

Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment.

Frontiers in bioengineering and biotechnology

Chantal Voskamp, Wendy J L M Koevoet, Rodrigo A Somoza, Arnold I Caplan, Véronique Lefebvre, Gerjo J V M van Osch, Roberto Narcisi

Affiliations

  1. Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  2. Department of Otorhinolaryngology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  3. Department of Biology and Skeletal Research Center, Case Western Reserve University, Cleveland, OH, United States.
  4. Division of Orthopedic Surgery, Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.

PMID: 32714905 PMCID: PMC7344141 DOI: 10.3389/fbioe.2020.00658

Abstract

Mesenchymal stem cells (MSCs) are promising cells to treat cartilage defects due to their chondrogenic differentiation potential. However, an inflammatory environment during differentiation, such as the presence of the cytokine TNFα, inhibits chondrogenesis and limits the clinical use of MSCs. On the other hand, it has been reported that exposure to TNFα during

Copyright © 2020 Voskamp, Koevoet, Somoza, Caplan, Lefebvre, van Osch and Narcisi.

Keywords: SOXC transcription factors; cartilage; chondrogenesis; mesenchymal stem cells; regenerative medicine; tissue engineering; tumor necrosis factor-alpha

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