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Asia Ocean J Nucl Med Biol. 2020;8(2):102-108. doi: 10.22038/AOJNMB.2020.47399.1321.

Evaluation of D-isomer of .

Asia Oceania journal of nuclear medicine & biology

Nobuto Hirai, Tadashi Watabe, Shushi Nagamori, Pattama Wiriyasermkul, Yoko Tanaka, Victor Romanov, Sadahiro Naka, Yasukazu Kanai, Yuwei Liu, Naoki Tani, Tatsuya Sakai, Mitsuaki Tatsumi, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa

Affiliations

  1. Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
  2. Institute for Radiation Sciences, Osaka University, Osaka, Japan.
  3. Department of Bio-system Pharmacology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
  4. Laboratory of Biomolecular Dynamics, Department of Collaborative Research, Nara Medical University, Nara, Japan.
  5. Deparment of Radiology, Osaka University Hospital, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
  6. Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
  7. Research Center for Nuclear Physics, Osaka University, Osaka, Japan.

PMID: 32714997 PMCID: PMC7354242 DOI: 10.22038/AOJNMB.2020.47399.1321

Abstract

OBJECTIVES: L-4-borono-2-

METHODS: HEK293-LAT1 and HEK293-LAT2 cells were tested for [

RESULTS: In contrast to L-FBPA, which inhibited substrate uptake in both HEK293-LAT1 and -LAT2 cells, D-FBPA showed no inhibitory effect on both cells, suggesting low transporter selectivity of D-[

CONCLUSION: This study demonstrated that D-[

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Keywords: C6 glioma; FBPA; Inflammation; LAT1; Small animal

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