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Kujawska M, La Rosa SL, Roger LC, et al. Succession of Bifidobacterium longum Strains in Response to a Changing Early Life Nutritional Environment Reveals Dietary Substrate Adaptations. iScience. 2020;23(8):101368doi: 10.1016/j.isci.2020.101368.
Kujawska, M., La Rosa, S. L., Roger, L. C., Pope, P. B., Hoyles, L., McCartney, A. L., & Hall, L. J. (2020). Succession of Bifidobacterium longum Strains in Response to a Changing Early Life Nutritional Environment Reveals Dietary Substrate Adaptations. iScience, 23(8), 101368. https://doi.org/10.1016/j.isci.2020.101368
Kujawska, Magdalena, et al. "Succession of Bifidobacterium longum Strains in Response to a Changing Early Life Nutritional Environment Reveals Dietary Substrate Adaptations." iScience vol. 23,8 (2020): 101368. doi: https://doi.org/10.1016/j.isci.2020.101368
Kujawska M, La Rosa SL, Roger LC, Pope PB, Hoyles L, McCartney AL, Hall LJ. Succession of Bifidobacterium longum Strains in Response to a Changing Early Life Nutritional Environment Reveals Dietary Substrate Adaptations. iScience. 2020 Aug 21;23(8):101368. doi: 10.1016/j.isci.2020.101368. Epub 2020 Jul 15. PMID: 32721872; PMCID: PMC7390879.
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iScience. 2020 Aug 21;23(8):101368. doi: 10.1016/j.isci.2020.101368. Epub 2020 Jul 15.

Succession of Bifidobacterium longum Strains in Response to a Changing Early Life Nutritional Environment Reveals Dietary Substrate Adaptations.

iScience

Magdalena Kujawska, Sabina Leanti La Rosa, Laure C Roger, Phillip B Pope, Lesley Hoyles, Anne L McCartney, Lindsay J Hall

Affiliations

  1. Gut Microbes & Health, Quadram Institute Biosciences, Norwich Research Park, Norwich NR4 7UQ, UK.
  2. Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1433 Aas, Norway.
  3. Department of Food & Nutritional Sciences, University of Reading, Reading RG6 6LA, UK.
  4. Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1433 Aas, Norway; Faculty of Biosciences, Norwegian University of Life Sciences, 1433 Aas, Norway.
  5. Department of Biosciences, Nottingham Trent University, Nottingham NG11 8NS, UK.
  6. Gut Microbes & Health, Quadram Institute Biosciences, Norwich Research Park, Norwich NR4 7UQ, UK; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK; Chair of Intestinal Microbiome, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany; ZIEL - Institute for Food & Health, Technical University of Munich, 85354 Freising, Germany. Electronic address: [email protected].

PMID: 32721872 PMCID: PMC7390879 DOI: 10.1016/j.isci.2020.101368

Abstract

Diet-microbe interactions play a crucial role in modulation of the early life microbiota and infant health. Bifidobacterium dominates the breast-fed infant gut and may persist in individuals during transition from a milk-based to a more diversified diet. Here, we investigated adaptation of Bifidobacterium longum to the changing nutritional environment. Genomic characterization of 75 strains isolated from nine either exclusively breast- or formula-fed (pre-weaning) infants in their first 18 months revealed subspecies- and strain-specific intra-individual genomic diversity with respect to carbohydrate metabolism, which corresponded to different dietary stages. Complementary phenotypic studies indicated strain-specific differences in utilization of human milk oligosaccharides and plant carbohydrates, whereas proteomic profiling identified gene clusters involved in metabolism of selected carbohydrates. Our results indicate a strong link between infant diet and B. longum diversity and provide additional insights into possible competitive advantage mechanisms of this Bifidobacterium species and its persistence in a single host.

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Keywords: Dietary Supplement; Microbiology; Microbiome

Conflict of interest statement

Declaration of Interests The authors declare no competing interests.

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