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Holtappels R, Freitag K, Renzaho A, et al. Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors. Vaccines (Basel). 2020;8(3)doi: 10.3390/vaccines8030402.
Holtappels, R., Freitag, K., Renzaho, A., Becker, S., Lemmermann, N. A. W., & Reddehase, M. J. (2020). Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors. Vaccines, 8(3), . https://doi.org/10.3390/vaccines8030402
Holtappels, Rafaela, et al. "Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors." Vaccines vol. 8,3 (2020). doi: https://doi.org/10.3390/vaccines8030402
Holtappels R, Freitag K, Renzaho A, Becker S, Lemmermann NAW, Reddehase MJ. Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors. Vaccines (Basel). 2020 Jul 22;8(3). doi: 10.3390/vaccines8030402. PMID: 32707744; PMCID: PMC7563500.
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Vaccines (Basel). 2020 Jul 22;8(3). doi: 10.3390/vaccines8030402.

Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors.

Vaccines

Rafaela Holtappels, Kirsten Freitag, Angelique Renzaho, Sara Becker, Niels A W Lemmermann, Matthias J Reddehase

Affiliations

  1. Institute for Virology and Research Center for Immunotherapy (FZI) at the University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.

PMID: 32707744 PMCID: PMC7563500 DOI: 10.3390/vaccines8030402

Abstract

Murine models of cytomegalovirus (CMV) infection have revealed an exceptional kinetics of the immune response. After resolution of productive infection, transient contraction of the viral epitope-specific CD8 T-cell pool was found to be followed by a pool expansion specific for certain viral epitopes during non-productive 'latent' infection. This phenomenon, known as 'memory inflation' (MI), was found to be based on inflationary KLRG1

Keywords: KLRG1; avidity maturation; central memory CD8 T cells (TCM); conventional TEM (cTEM); cytomegalovirus; effector memory CD8 T cells (TEM); inflationary TEM (iTEM); memory inflation; vaccine vector

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