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Zhu LL, Dong PW, Su X, et al. [Endoscopic Characteristics and Pathological Analysis of Esophageal Low-grade Intraepithelial Neoplasm]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2018;49(6):849-853
Zhu, L. L., Dong, P. W., Su, X., Liu, X. B., Gan, T., Wu, J. C., Wang, Y. P., & Yang, J. L. (2018). [Endoscopic Characteristics and Pathological Analysis of Esophageal Low-grade Intraepithelial Neoplasm]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 49(6), 849-853.
Zhu, Lin-Lin, et al. "[Endoscopic Characteristics and Pathological Analysis of Esophageal Low-grade Intraepithelial Neoplasm]." Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition vol. 49,6 (2018): 849-853.
Zhu LL, Dong PW, Su X, Liu XB, Gan T, Wu JC, Wang YP, Yang JL. [Endoscopic Characteristics and Pathological Analysis of Esophageal Low-grade Intraepithelial Neoplasm]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):849-853. Chinese. PMID: 32677391.
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Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):849-853.

[Endoscopic Characteristics and Pathological Analysis of Esophageal Low-grade Intraepithelial Neoplasm].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

[Article in Chinese]
Lin-Lin Zhu, Pei-Wen Dong, Xing Su, Xin-Bing Liu, Tao Gan, Jun-Chao Wu, Yi-Ping Wang, Jin-Lin Yang

Affiliations

  1. Department of International Medical Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  2. Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.

PMID: 32677391

Abstract

OBJECTIVE: To explore endoscopic characteristics and pathological changes of esophageal low-grade intraepithelial neoplasm (LGIN) as well as its risk factors.

METHODS: A total of 201 LGIN lesions from 169 cases were included from January 2009 to August 2017. The endoscopic characteristics and pathological changes were analysis. Logistic regression analysis was used to analyze the risk factors of LGIN. The endoscopic morphologic findings of esophageal mucosa lesions and the pathological findings of simple inflammatory lesions were enrolled as controls.

RESULTS: LGIN occurred more common in elderly patients, the ratio of male to female was 2.5∶1. The maximum transverse and the maximum longitudinal diameter (MLD) were (0.9±0.8) cm,(1.4±1.3) cm, respectively. The most common location of lesion was in the middle segment of esophagus (52.2%). The morphological types of lesions were dominantly 0-Ⅱb (45.8%) and 0-Ⅱa (31.8%). There were 42 LGIN lesions with reflux esophagitis. Multiple dysplastic lesions accounted for 57.4%. After (10.3±12.1) months follow-up, 58.2% lesions were pathological reversal with 24.9% (50/201) of the lesion completely disappeared, and 28.9% lesions had no pathological changes, but 12.9% (26/201) lesions progressed to high-grade intraepithelial neoplasia and invasive cancer. Multivariate analysis indicated that age (compared to <45 years old) and longitudinal diameter of the lesion (compared to ≤0.5 cm) were independent risk factors for LGIN. The risk of esophageal LGIN in lesions with MLD > 0.5-1 cm was 1.96 times higher than that in lesions with MLD ≤ 0.5 cm.

CONCLUSIONS: The MLD of esophageal mucosal lesions >0.5 cm and age >45 years old may increase the possibility of esophageal LGIN. Close follow-up is required for LGIN lesions with MLD>1 cm.

Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).

Keywords: Esophadus; Low-grade intraepithelial neoplasm; Pathological change; Risk factors

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