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Mi YJ, Liang LJ, Ci CH, et al. [The Role of PPE25 in Mycobacterial Infections of Polymorphonuclear Neutrophils]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2018;49(6):871-875
Mi, Y. J., Liang, L. J., Ci, C. H., & Wang, Y. Y. (2018). [The Role of PPE25 in Mycobacterial Infections of Polymorphonuclear Neutrophils]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 49(6), 871-875.
Mi, You-Jun, et al. "[The Role of PPE25 in Mycobacterial Infections of Polymorphonuclear Neutrophils]." Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition vol. 49,6 (2018): 871-875.
Mi YJ, Liang LJ, Ci CH, Wang YY. [The Role of PPE25 in Mycobacterial Infections of Polymorphonuclear Neutrophils]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):871-875. Chinese. PMID: 32677395.
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Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):871-875.

[The Role of PPE25 in Mycobacterial Infections of Polymorphonuclear Neutrophils].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

[Article in Chinese]
You-Jun Mi, Li-Juan Liang, Cai-Hong Ci, Yue-Ying Wang

Affiliations

  1. Medical College of Northwest Minzu University, Lanzhou 730000, China.
  2. College of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.

PMID: 32677395

Abstract

OBJECTIVE: To determine the role of PPE25 in the infection of

METHODS: In MS-ppe25 group, PPE25 was expressed in non-pathogenic fast-growing

RESULTS: PPE25 protein had no effect on MS growth, colony formation and the size of single colonies. MS-infected PMN had higher percentages of CFU and LDH release 2, 6, and 12 h after infections compared with the MS-vec group (

CONCLUSIONS: PPE25 protein increases the survival of MS in PMN, induces cell necrosis, inhibits the expressions of ROS and NO, and changes the secretion of cytokines, which helps spread of the pathogen by evading host immunity.

Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).

Keywords: Mycobacterium tuberculosis; PPE25; Polymorphonuclear neutrophils

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