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Hui ZY, Zhang X, Sun HM, et al. [The Function of Potassium Channel in . Sichuan Da Xue Xue Bao Yi Xue Ban. 2018;49(6):876-880
Hui, Z. Y., Zhang, X., Sun, H. M., & Zhou, X. H. (2018). [The Function of Potassium Channel in . Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 49(6), 876-880.
Hui, Zhi-Yan, et al. "[The Function of Potassium Channel in ." Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition vol. 49,6 (2018): 876-880.
Hui ZY, Zhang X, Sun HM, Zhou XH. [The Function of Potassium Channel in . Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):876-880. Chinese. PMID: 32677396.
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Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):876-880.

[The Function of Potassium Channel in .

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

[Article in Chinese]
Zhi-Yan Hui, Xu Zhang, Hong-Mei Sun, Xi-Hui Zhou

Affiliations

  1. Department of Critical Care Medicine, Yan'an University Affiliated Hospital, Yan'an 716000, China.
  2. Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

PMID: 32677396

Abstract

OBJECTIVE: To determine the function of potassium channel in

METHODS: HEK293 cells were transfected with pcDNA3-WT-

RESULTS: G271V mutants did not show currents in the transfected HEK cells, inducing large depolarizing shift of the conductance voltage relationship and slowing down the current activation kinetics. The required current density was (2.47±0.41) pA/pF (

CONCLUSIONS: The G271V channel fails to open potassium currents in response to depolarization, indicating a more severe functional defect of the Kv7 potassium channel.

Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).

Keywords: Epilepsy; KCNQ2; Kv7.2; Patch-clamp electrophysiology; Voltage-gated potassium channel

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