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Lin SB, Hu C, Qin YP, et al. [Pharmacokinetics Study of Phentolamine Mesylate Injection in Healthy Volunteers]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2018;49(6):929-933
Lin, S. B., Hu, C., Qin, Y. P., Miao, J., Feng, S. Y., Shu, S. Q., Nan, F., Wang, Y., Zhu, X. H., & Liang, M. Z. (2018). [Pharmacokinetics Study of Phentolamine Mesylate Injection in Healthy Volunteers]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 49(6), 929-933.
Lin, Shi-Bei-Lei, et al. "[Pharmacokinetics Study of Phentolamine Mesylate Injection in Healthy Volunteers]." Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition vol. 49,6 (2018): 929-933.
Lin SB, Hu C, Qin YP, Miao J, Feng SY, Shu SQ, Nan F, Wang Y, Zhu XH, Liang MZ. [Pharmacokinetics Study of Phentolamine Mesylate Injection in Healthy Volunteers]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):929-933. Chinese. PMID: 32677407.
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Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Nov;49(6):929-933.

[Pharmacokinetics Study of Phentolamine Mesylate Injection in Healthy Volunteers].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

[Article in Chinese]
Shi-Bei-Lei Lin, Chao Hu, Yong-Ping Qin, Jia Miao, Shi-Yin Feng, Shi-Qing Shu, Feng Nan, Ying Wang, Xiao-Hong Zhu, Mao-Zhi Liang

Affiliations

  1. Phase ? Clinical Research Unit, West China Hospital, Sichuan University, Chengdu 610041, China.

PMID: 32677407

Abstract

OBJECTIVE: To study the pharmacokinetic profile of phentolamine mesylate injection in healthy Chinese volunteers.

METHODS: A total of 16 healthy volunteers were randomly divided into two groups, each receiving anterior teeth submucosal infiltration anesthesia and inferior alveolar nerve block anesthesia, respectively. The participants were injected with 0.9 mL, 1.8 mL, and 3.6 mL of 2% lidocaine HCl with 1∶100 000 epinephrine over three periods sequentially, followed by corresponding sequential injection of 0.2 mg, 0.4 mg, 0.8 mg of phentolamine mesylate at the same sites 30 min later.Blood samples were drawn from 5 min before injection to 15 h post the injection of phentolamine mesylate (16 time points). Adverse events were closely observed all the time. Plasma phentolamine mesylate was detected using UPLC-MS/MS with isotope as internal standard. WinNolin 6.1 software was used to calculate the pharmacokinetic parameters.

RESULTS: Time to peak concerntration (

CONCLUSIONS: Phentolamine mesylate injection is effective for reversing oral local anesthetic effects.

Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).

Keywords: Healthy volunteers; Pharmacokinetics; Phentolamine mesylate injection

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