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Iannantuoni F, M de Marañon A, Abad-Jiménez Z, et al. Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes. J Clin Med. 2020;9(7)doi: 10.3390/jcm9072155.
Iannantuoni, F., M de Marañon, A., Abad-Jiménez, Z., Canet, F., Díaz-Pozo, P., López-Domènech, S., Morillas, C., Rocha, M., & Víctor, V. M. (2020). Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes. Journal of clinical medicine, 9(7), . https://doi.org/10.3390/jcm9072155
Iannantuoni, Francesca, et al. "Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes." Journal of clinical medicine vol. 9,7 (2020). doi: https://doi.org/10.3390/jcm9072155
Iannantuoni F, M de Marañon A, Abad-Jiménez Z, Canet F, Díaz-Pozo P, López-Domènech S, Morillas C, Rocha M, Víctor VM. Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes. J Clin Med. 2020 Jul 08;9(7). doi: 10.3390/jcm9072155. PMID: 32650465; PMCID: PMC7408780.
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J Clin Med. 2020 Jul 08;9(7). doi: 10.3390/jcm9072155.

Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes.

Journal of clinical medicine

Francesca Iannantuoni, Aranzazu M de Marañon, Zaida Abad-Jiménez, Francisco Canet, Pedro Díaz-Pozo, Sandra López-Domènech, Carlos Morillas, Milagros Rocha, Víctor M Víctor

Affiliations

  1. Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain.
  2. CIBERehd-Department of Pharmacology and Physiology, University of Valencia, 46010 Valencia, Spain.
  3. Department of Physiology, University of Valencia, 46010 Valencia, Spain.

PMID: 32650465 PMCID: PMC7408780 DOI: 10.3390/jcm9072155

Abstract

Type 1 diabetes has been associated with oxidative stress. This study evaluates the rates of oxidative stress, mitochondrial function, leukocyte-endothelium interactions and adhesion molecules in type 1 diabetic patients. The study population consisted of 52 diabetic patients and 46 body-composition and age-matched controls. We assessed anthropometric and metabolic parameters, oxidative stress and mitochondrial function by evaluating reactive oxygen species (ROS) production, mitochondrial ROS production, mitochondrial membrane potential and superoxide dismutase (SOD) and catalase (CAT) expression in polymorphonuclear leukocytes from type 1 diabetic patients. In addition, we evaluated interactions between leukocytes and human umbilical vein endothelial cells (HUVEC), and serum expression of adhesion molecules (P-selectin, VCAM-1 and ICAM-1), proinflammatory cytokines (IL-6 and TNFα) and myeloperoxidase (MPO). HbA

Keywords: cardiovascular risk; endothelium; inflammation; mitochondria; type 1 diabetes

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