Int J Fertil Steril. 2020 Jul;14(2):79-83. doi: 10.22074/ijfs.2020.6092. Epub 2020 Jul 15.
Male Equivalent Polycystic Ovarian Syndrome: Hormonal, Metabolic, and Clinical Aspects.
International journal of fertility & sterility
Federica Di Guardo, Lilliana Ciotta, Morena Monteleone, Marco Palumbo
Affiliations
Affiliations
- Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.Electronic Address: [email protected].
- Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.
PMID: 32681618
PMCID: PMC7382675 DOI: 10.22074/ijfs.2020.6092
Abstract
Recent studies identified the presence of a male polycystic ovarian syndrome (PCOS), which mainly affects men whose female relatives are afflicted with PCOS, caused by genes responsible for the susceptibility of this syndrome in women. Similar hormonal, metabolic, and clinical alterations occurring in PCOS women have also been reported in their male relatives, suggesting a association between the male and female forms of the syndrome. Although the remarkable clinical manifestation of the male equivalent PCOS is diagnosed by the early-onset androgenetic alopecia, character-ized by hair recession, pronounced hypertrichosis, insulin resistance, biochemical and hormonal abnormalities, the hormonal/metabolic profile is still controversial. Men affected by early-onset androgenetic alopecia (AGA) are at risk of developing hyperinsulinemia, insulin-resistance, dyslipidaemia, and cardiovascular diseases. However, there is no consensus on the association of male equivalent PCOS with hypertension and obesity. Moreover, reduced levels of sex hormone-binding globulin have been detected in these male patients, accompanied by increased free androgens. Conversely, literature reported lower concentrations of testosterone in male equivalent PCOS when compared with the normal range, indicating a crucial role for the conversion of cortical androgens. Finally, further studies are warranted to investigate a possible link among AGA, metabolic/hormonal alterations, and acne. Our study assessed the hormo-nal, metabolic and clinical aspects of male equivalent PCOS syndrome reported in the literature to evaluate similar and divergent elements involved in the female version of the syndrome.
Copyright© by Royan Institute. All rights reserved.
Keywords: Androgenetic Alopecia; Insulin Resistance; Polycystic Ovarian Syndrome
Conflict of interest statement
The authors declare no conflicts of interest.
References
- Endocr Regul. 2005 Dec;39(4):127-31 - PubMed
- JAMA Dermatol. 2016 Apr;152(4):399-404 - PubMed
- Ann N Y Acad Sci. 1951 Mar;53(3):708-28 - PubMed
- Br J Dermatol. 2010 Apr;162(4):786-9 - PubMed
- Exp Clin Endocrinol Diabetes. 2004 Jan;112(1):24-8 - PubMed
- J Am Acad Dermatol. 2011 Jul;65(1):48-53 - PubMed
- Med Hypotheses. 2007;68(3):480-3 - PubMed
- Lancet. 2000 Sep 30;356(9236):1165-6 - PubMed
- Br J Dermatol. 2012 Aug;167(2):306-13 - PubMed
- Int J Trichology. 2015 Oct-Dec;7(4):141-7 - PubMed
- J Complement Integr Med. 2019 Sep 17;17(2): - PubMed
- Int J Trichology. 2013 Apr;5(2):69-72 - PubMed
- Clin Endocrinol (Oxf). 1993 Jun;38(6):653-8 - PubMed
- Actas Dermosifiliogr. 2010 Apr;101(3):248-56 - PubMed
- J Biol Chem. 2013 May 31;288(22):15937-46 - PubMed
- Sb Lek. 2000;101(1):17-22 - PubMed
- Fertil Steril. 1996 Dec;66(6):942-7 - PubMed
- Reprod Biomed Online. 2005 Jun;10(6):713-20 - PubMed
- Br J Dermatol. 2010 Aug;163(2):371-7 - PubMed
- Physiol Res. 2004;53(3):287-94 - PubMed
- Reprod Biol. 2016 Mar;16(1):53-60 - PubMed
- Eur J Dermatol. 2011 Jan-Feb;21(1):79-82 - PubMed
- Med Hypotheses. 2019 May;126:1-3 - PubMed
- Dermatol Res Pract. 2015;2015:980310 - PubMed
- Cent Eur J Public Health. 2006 Jun;14(2):78-81 - PubMed
- J Clin Endocrinol Metab. 2007 Apr;92(4):1289-95 - PubMed
- J Endocrinol Invest. 2018 Jan;41(1):49-57 - PubMed
- Clin Endocrinol (Oxf). 2004 Mar;60(3):322-8 - PubMed
- J Pediatr Endocrinol Metab. 2000;13 Suppl 5:1307-9 - PubMed
- Endocrine. 2012 Dec;42(3):555-60 - PubMed
- Zhejiang Da Xue Xue Bao Yi Xue Ban. 2014 Sep;43(5):597-601 - PubMed
- JAMA Dermatol. 2016 Sep 1;152(9):986-91 - PubMed
- Curr Pharm Des. 2019;25(22):2467-2473 - PubMed
- Gynecol Obstet Invest. 1989;28(1):23-30 - PubMed
- South Med J. 1975 Nov;68(11):1359-65 - PubMed
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